Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Miguel A S, Cavadas"'
Autor:
Carsten C Scholz, Javier Rodriguez, Christina Pickel, Stephen Burr, Jacqueline-Alba Fabrizio, Karen A Nolan, Patrick Spielmann, Miguel A S Cavadas, Bianca Crifo, Doug N Halligan, James A Nathan, Daniel J Peet, Roland H Wenger, Alex Von Kriegsheim, Eoin P Cummins, Cormac T Taylor
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002347 (2016)
The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a g
Externí odkaz:
https://doaj.org/article/195eb6b4e4534a8d981fea77cbdb36dd
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1742
Here we describe a simple method based on secreted luciferase driven by a hypoxia-inducible factor (HIF) response element (HRE) that allows the acquisition of dynamic and high-throughput data on HIF transcriptional activity during hypoxia and pharmac
Autor:
Miguel A S, Cavadas, Marion, Mesnieres, Bianca, Crifo, Mario C, Manresa, Andrew C, Selfridge, Ciara E, Keogh, Zsolt, Fabian, Carsten C, Scholz, Karen A, Nolan, Liliane M A, Rocha, Murtaza M, Tambuwala, Stuart, Brown, Anita, Wdowicz, Danielle, Corbett, Keith J, Murphy, Catherine, Godson, Eoin P, Cummins, Cormac T, Taylor, Alex, Cheong
Publikováno v:
Scientific Reports
Cellular exposure to hypoxia results in altered gene expression in a range of physiologic and pathophysiologic states. Discrete cohorts of genes can be either up- or down-regulated in response to hypoxia. While the Hypoxia-Inducible Factor (HIF) is t
Publikováno v:
Cellular and Molecular Life Sciences
Cyclooxygenase 2 (COX2), a key regulatory enzyme of the prostaglandin/eicosanoid pathway, is an important target for anti-inflammatory therapy. It is highly induced by pro-inflammatory cytokines in a Nuclear factor kappa B (NFκB)-dependent manner. H
Autor:
Miguel A S, Cavadas, Alex, Cheong
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1098
Genetic experiments over the last few decades have identified many regulatory proteins critical for DNA transcription. The dynamics of their transcriptional activities shape the differential expression of the genes they control. Here we describe a si