Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Miguel A Perez-pinzon"'
Publikováno v:
Brain Circulation, Vol 4, Iss 2, Pp 54-61 (2018)
Stroke and cardiac arrest result in cerebral ischemia, a highly prevalent medical issue around the world, which is characterized by a reduction or loss of blood flow to the brain. The loss of adequate nutrient supply in the brain during ischemia resu
Externí odkaz:
https://doaj.org/article/d103b82e758045dcb4a6d10e5a73b413
Publikováno v:
Brain Circulation, Vol 1, Iss 1, Pp 69-78 (2015)
Cerebral ischemia is among the leading causes of death worldwide. It is characterized by a lack of blood flow to the brain that results in cell death and damage, ultimately causing motor, sensory, and cognitive impairments. Today, clinical treatment
Externí odkaz:
https://doaj.org/article/ff352a9af6c34e3fa19b3e3cbcbe1f48
Autor:
Charles H Cohan, Jake T Neumann, Kunjan R Dave, Aleksey Alekseyenko, Marc Binkert, Kenneth Stransky, Hung Wen Lin, Carol A Barnes, Clinton B Wright, Miguel A Perez-Pinzon
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124918 (2015)
Cardiopulmonary arrest is a leading cause of death and disability in the United States that usually occurs in the aged population. Cardiac arrest (CA) induces global ischemia, disrupting global cerebral circulation that results in ischemic brain inju
Externí odkaz:
https://doaj.org/article/a0fa72065d124c608ba7a0992e67c829
Autor:
Ami P Raval, Raquel Borges-Garcia, William Javier Moreno, Miguel A Perez-Pinzon, Helen Bramlett
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60716 (2013)
Although chronic 17β-estradiol (E2) has been shown to be a cognition-preserving and neuroprotective agent in animal brain injury models, concern regarding its safety was raised by the failed translation of this phenomenon to the clinic. Previously,
Externí odkaz:
https://doaj.org/article/b31ea98682fb42b795e0e7792448d138
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75753 (2013)
Ischemic preconditioning is a neuroprotective mechanism whereby a sublethal ischemic exposure is protective against a subsequent lethal ischemic attack. We previously demonstrated that SIRT1, a nuclear localized stress-activated deacetylase, is vital
Externí odkaz:
https://doaj.org/article/c0ac4bdf8fef470498d94e1b3512484c
Autor:
Kunjan R Dave, Sanjoy K Bhattacharya, Isabel Saul, R Anthony DeFazio, Cameron Dezfulian, Hung Wen Lin, Ami P Raval, Miguel A Perez-Pinzon
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22057 (2011)
The release of cytochrome c from the mitochondria following cerebral ischemia is a key event leading to cell death. The goal of the present study was to determine the mechanisms involved in post-ischemic activation of protein kinase c delta (δPKC) t
Externí odkaz:
https://doaj.org/article/355f6fc96e504e0781c95a774052e861
Autor:
Eric Fagerli, Charles W. Jackson, Iris Escobar, Fernando J. Ferrier, Efrain J. Perez Lao, Isabel Saul, Jorge Gomez, Kunjan R. Dave, Oliver Bracko, Miguel A. Perez-Pinzon
Publikováno v:
Antioxidants, Vol 13, Iss 8, p 984 (2024)
Vascular cognitive impairment and dementia (VCID) is the second leading cause of dementia. There is currently no effective treatment for VCID. Resveratrol (RSV) is considered an antioxidant; however, our group has observed pleiotropic effects in stro
Externí odkaz:
https://doaj.org/article/0c25d7ebbefb41b6b1afe1c0e5914e91
Autor:
Eric Fagerli, Iris Escobar, Fernando J. Ferrier, Charles W. Jackson, Efrain J. Perez-Lao, Miguel A. Perez-Pinzon
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Sirtuins are an evolutionarily conserved family of regulatory proteins that function in an NAD+ -dependent manner. The mammalian family of sirtuins is composed of seven histone deacetylase and ADP-ribosyltransferase proteins (SIRT1-SIRT7) that are fo
Externí odkaz:
https://doaj.org/article/f62d38df2ffe4a01838d28c1fadf6a68
Autor:
Shahil H. Patel, Alba Timón-Gómez, Hari Pradhyumnan, Berk Mankaliye, Kunjan R. Dave, Miguel A. Perez-Pinzon, Ami P. Raval
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 16075 (2022)
Smoking-derived nicotine (N) and oral contraceptive (OC) synergistically exacerbate ischemic brain damage in females, and the underlying mechanisms remain elusive. In a previous study, we showed that N + OC exposure altered brain glucose metabolism i
Externí odkaz:
https://doaj.org/article/39d3845fc487419fa5dbc79a0bd31560
Autor:
Ashish K. Rehni, Sunjoo Cho, Zhexuan Zhang, Priyanka Khushal, Ami P. Raval, Sebastian Koch, Miguel A. Perez-Pinzon, Weizhao Zhao, Wenche Jy, Kunjan R. Dave
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15167 (2022)
Spontaneous intracerebral hemorrhage (sICH) is a disabling stroke sub-type, and tobacco use is a prominent risk factor for sICH. We showed that chronic nicotine exposure enhances bleeding post-sICH. Reduction of hematoma growth is a promising effecti
Externí odkaz:
https://doaj.org/article/cea1dc00373f4479b2bc7e704e736697