Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Miguel A Gonzalez-Lozano"'
Autor:
Aygul Subkhangulova, Miguel A Gonzalez-Lozano, Alexander JA Groffen, Jan RT van Weering, August B Smit, Ruud F Toonen, Matthijs Verhage
Publikováno v:
eLife, Vol 12 (2023)
Tomosyn is a large, non-canonical SNARE protein proposed to act as an inhibitor of SNARE complex formation in the exocytosis of secretory vesicles. In the brain, tomosyn inhibits the fusion of synaptic vesicles (SVs), whereas its role in the fusion o
Externí odkaz:
https://doaj.org/article/5b14d100d8134e01bd5d91d6962c2b54
Publikováno v:
Cells, Vol 13, Iss 1, p 14 (2023)
GABAA receptors are the major inhibitory receptors in the brain. They are hetero-pentamers with a composition of predominantly two α, two β, and one γ or δ subunit. Of the six α subunit genes, the α5 subunit displays a limited spatial expressio
Externí odkaz:
https://doaj.org/article/d7f9b4d52a7645c69f1d564e94edeec5
Autor:
Sang S. Seo, Susana R. Louros, Natasha Anstey, Miguel A. Gonzalez-Lozano, Callista B. Harper, Nicholas C. Verity, Owen Dando, Sophie R. Thomson, Jennifer C. Darnell, Peter C. Kind, Ka Wan Li, Emily K. Osterweil
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Dysregulated protein synthesis is key contributor to Fragile X syndrome. Here the authors identify a relationship between ribosome expression and the translation of long mRNAs that contributes to synaptic weakening in a model of Fragile X syndrome.
Externí odkaz:
https://doaj.org/article/8ae6ea90e044406685e3c0bd724e960e
Autor:
Annemiek A. Van Berkel, Frank Koopmans, Miguel Angel Gonzalez-Lozano, Hanna C. A. Lammertse, Femke Feringa, Julien Bryois, Patrick F. Sullivan, August B. Smit, Ruud F. Toonen, Matthijs Verhage
Publikováno v:
eNeuro, 9(6):ENEURO.0186-22.2022. Society for Neuroscience
Van Berkel, A A, Koopmans, F, Gonzalez-Lozano, M A, Lammertse, H C A, Feringa, F, Bryois, J, Sullivan, P F, Smit, A B, Toonen, R F & Verhage, M 2022, ' Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1 ', eNeuro, vol. 9, no. 6, pp. 1-14 . https://doi.org/10.1523/ENEURO.0186-22.2022
eNeuro, 9(6), 1-14. Society for Neuroscience
van Berkel, A A, Koopmans, F, Gonzalez-Lozano, M A, Lammertse, H C A, Feringa, F, Bryois, J, Sullivan, P F, Smit, A B, Toonen, R F & Verhage, M 2022, ' Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1 ', eNeuro, vol. 9, no. 6, ENEURO.0186-22.2022 . https://doi.org/10.1523/ENEURO.0186-22.2022
Van Berkel, A A, Koopmans, F, Gonzalez-Lozano, M A, Lammertse, H C A, Feringa, F, Bryois, J, Sullivan, P F, Smit, A B, Toonen, R F & Verhage, M 2022, ' Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1 ', eNeuro, vol. 9, no. 6, pp. 1-14 . https://doi.org/10.1523/ENEURO.0186-22.2022
eNeuro, 9(6), 1-14. Society for Neuroscience
van Berkel, A A, Koopmans, F, Gonzalez-Lozano, M A, Lammertse, H C A, Feringa, F, Bryois, J, Sullivan, P F, Smit, A B, Toonen, R F & Verhage, M 2022, ' Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1 ', eNeuro, vol. 9, no. 6, ENEURO.0186-22.2022 . https://doi.org/10.1523/ENEURO.0186-22.2022
Absence of presynaptic protein MUNC18-1 (gene:Stxbp1) leads to neuronal cell death at an immature stage before synapse formation. Here, we performed transcriptomic and proteomic profiling of immatureStxbp1knock-out (KO) cells to discover which cellul
Autor:
Aygul Subkhangulova, Miguel A. Gonzalez-Lozano, Alexander J. A. Groffen, Jan R. T. van Weering, August B. Smit, Ruud F. Toonen, Matthijs Verhage
Tomosyn is a large, non-canonical SNARE protein proposed to act as a competitive inhibitor of SNARE complex formation in vesicle exocytosis. In the brain, tomosyn inhibits fusion of synaptic vesicles (SVs), whereas its role in the fusion of neuropept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05abb6bf6d0dd1a5a2687f58508195b0
https://doi.org/10.1101/2022.12.18.520925
https://doi.org/10.1101/2022.12.18.520925
Autor:
Susana R. Louros, Sang S. Seo, Beatriz Maio, Cristina Martinez-Gonzalez, Miguel A. Gonzalez-Lozano, Melania Muscas, Nick C. Verity, Jimi C. Wills, Ka Wan Li, Matthew F. Nolan, Emily K. Osterweil
Publikováno v:
Louros, S R, Seo, S S, Maio, B, Martinez-Gonzalez, C, Gonzalez-Lozano, M A, Muscas, M, Verity, N C, Wills, J C, Li, K W, Nolan, M F & Osterweil, E K 2023, ' Excessive proteostasis contributes to pathology in fragile X syndrome ', Neuron, vol. 111, no. 4, pp. 508-525.e7 . https://doi.org/10.1016/j.neuron.2022.11.012
Ribeiro dos Louros, S, Seo, S, Maio, B, Martinez Gonzalez, C, Gonzalez-Lozano, M A, Muscas, M, Verity, N, Wills, J, Li, K W, Nolan, M F & Osterweil, E 2022, ' Excessive proteostasis contributes to pathology in Fragile X Syndrome ', Neuron . https://doi.org/10.1016/j.neuron.2022.11.012
Neuron, 111(4), 508-525.e7. Cell Press
Ribeiro dos Louros, S, Seo, S, Maio, B, Martinez Gonzalez, C, Gonzalez-Lozano, M A, Muscas, M, Verity, N, Wills, J, Li, K W, Nolan, M F & Osterweil, E 2022, ' Excessive proteostasis contributes to pathology in Fragile X Syndrome ', Neuron . https://doi.org/10.1016/j.neuron.2022.11.012
Neuron, 111(4), 508-525.e7. Cell Press
In fragile X syndrome (FX), the leading monogenic cause of autism, excessive neuronal protein synthesis is a core pathophysiology; however, an overall increase in protein expression is not observed. Here, we tested whether excessive protein synthesis
Autor:
Greta Pintacuda, Yu-Han H. Hsu, Kalliopi Tsafou, Ka Wan Li, Jacqueline M. Martín, Jackson Riseman, Julia C. Biagini, Joshua K.T. Ching, Daya Mena, Miguel A. Gonzalez-Lozano, Shawn B. Egri, Jake Jaffe, August B. Smit, Nadine Fornelos, Kevin C. Eggan, Kasper Lage
Publikováno v:
Cell Genomics, 3(3):100250, 1-28. Cell Press
Pintacuda, G, Hsu, Y H H, Tsafou, K, Li, K W, Martín, J M, Riseman, J, Biagini, J C, Ching, J K T, Mena, D, Gonzalez-Lozano, M A, Egri, S B, Jaffe, J, Smit, A B, Fornelos, N, Eggan, K C & Lage, K 2023, ' Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders ', Cell Genomics, vol. 3, no. 3, 100250, pp. 1-28 . https://doi.org/10.1016/j.xgen.2022.100250
Pintacuda, G, Hsu, Y H H, Tsafou, K, Li, K W, Martín, J M, Riseman, J, Biagini, J C, Ching, J K T, Mena, D, Gonzalez-Lozano, M A, Egri, S B, Jaffe, J, Smit, A B, Fornelos, N, Eggan, K C & Lage, K 2023, ' Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders ', Cell Genomics, vol. 3, no. 3, 100250, pp. 1-28 . https://doi.org/10.1016/j.xgen.2022.100250
Autism spectrum disorders (ASDs) have been linked to genes with enriched expression in the brain, but it is unclear how these genes converge into cell-type-specific networks. We built a protein-protein interaction network for 13 ASD-associated genes
Autor:
Sang S. Seo, Susana R. Louros, Natasha Anstey, Miguel A. Gonzalez-Lozano, Callista B. Harper, Nicholas C. Verity, Owen Dando, Sophie R. Thomson, Jennifer C. Darnell, Peter C. Kind, Ka Wan Li, Emily K. Osterweil
Dysregulated protein synthesis is a core pathogenic mechanism in Fragile X Syndrome (FX). The mGluR Theory of FX predicts that pathological synaptic changes arise from the excessive translation of mRNAs downstream of mGlu1/5 activation. Here, we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2190637137306e7721ec36cd611bab07
https://doi.org/10.1101/2022.04.07.487442
https://doi.org/10.1101/2022.04.07.487442
Autor:
Miguel A Gonzalez‐Lozano, Ka Wan Li
Publikováno v:
eLS. :1-9
Autor:
Ahmed Eltokhi, Miguel A. Gonzalez-Lozano, Lars-Lennart Oettl, Andrey Rozov, Claudia Pitzer, Ralph Röth, Simone Berkel, Markus Hüser, Aliona Harten, Wolfgang Kelsch, August B. Smit, Gudrun A. Rappold, Rolf Sprengel
Publikováno v:
Eltokhi, A, Gonzalez-Lozano, M A, Oettl, L-L, Rozov, A, Pitzer, C, Röth, R, Berkel, S, Hüser, M, Harten, A, Kelsch, W, Smit, A B, Rappold, G A & Sprengel, R 2021, ' Correction: Imbalanced post-and extrasynaptic SHANK2A functions during development affect social behavior in SHANK2-mediated neuropsychiatric disorders ', Molecular Psychiatry, vol. 26, no. 11, pp. 6505-6505 . https://doi.org/10.1038/s41380-021-01218-7
The original version of this article unfortunately contained a mistake. Joint senior authors information was missing. The corrected information is given below. Joint senior authors of the article https://doi.org/10.1038/s41380-021-01140-y are: Gudrun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fdd214a9a2f39a1503d44fd6e32311
https://hdl.handle.net/1871.1/5c41a8c3-d202-4086-9e84-f928e90fe9e8
https://hdl.handle.net/1871.1/5c41a8c3-d202-4086-9e84-f928e90fe9e8