Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Miguel A Andrade‐Navarro"'
Autor:
Mert Cihan, Miguel A Andrade-Navarro
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269731 (2022)
Gene activity is controlled by multiple molecular mechanisms, for instance through transcription factors or by microRNAs (miRNAs), among others. Established bioinformatics tools for the prediction of miRNA target genes face the challenge of ensuring
Externí odkaz:
https://doaj.org/article/b60ef7460ab84094a5e2ab2a88b2d7a4
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270043 (2022)
MotivationSingle-cell Chromatin ImmunoPrecipitation DNA-Sequencing (scChIP-seq) analysis is challenging due to data sparsity. High degree of sparsity in biological high-throughput single-cell data is generally handled with imputation methods that com
Externí odkaz:
https://doaj.org/article/94a3d8044bb3484eb3618434e23e8f9a
Autor:
Pablo Mier, Miguel A Andrade-Navarro
Publikováno v:
Evolutionary Bioinformatics, Vol 16 (2020)
Multiple sequence alignments are usually phylogenetically driven. They are studied in the framework of evolution. But sometimes, it is interesting to study residue conservation at positions unconstrained by evolutionary rules. We present a supervised
Externí odkaz:
https://doaj.org/article/5081bc70b1394835bac4f33c388f5c60
Autor:
Pablo Mier, Miguel A Andrade-Navarro
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0239154 (2020)
BackgroundProteins with low complexity regions (LCRs) have atypical sequence and structural features. Their amino acid composition varies from the expected, determined proteome-wise, and they do not follow the rules of structural folding that prevail
Externí odkaz:
https://doaj.org/article/c7e6900a33e7410b8da56cedd9018b8c
Autor:
Michael Lenz, Andreas Schulz, Thomas Koeck, Steffen Rapp, Markus Nagler, Madeleine Sauer, Lisa Eggebrecht, Vincent Ten Cate, Marina Panova-Noeva, Jürgen H Prochaska, Karl J Lackner, Thomas Münzel, Kirsten Leineweber, Philipp S Wild, Miguel A Andrade-Navarro
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243487 (2020)
Targeted proteomics utilizing antibody-based proximity extension assays provides sensitive and highly specific quantifications of plasma protein levels. Multivariate analysis of this data is hampered by frequent missing values (random or left censore
Externí odkaz:
https://doaj.org/article/5d98cac7517f43f2b9a0d0058d50a444
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210467 (2019)
The study of drug toxicity in human organs is complicated by their complex inter-relations and by the obvious difficulty to testing drug effects on biologically relevant material. Animal models and human cell cultures offer alternatives for systemati
Externí odkaz:
https://doaj.org/article/a27daa250f714ae4871ed6d81b48021b
Autor:
Óscar Llorián-Salvador, Nora Windeler, Nicole Martin, Lucas Etzel, Miguel A. Andrade-Navarro, Denise Bernhardt, Burkhard Rost, Kai J. Borm, Stephanie E. Combs, Marciana N. Duma, Jan C. Peeken
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Skin inflammation with the potential sequel of moist epitheliolysis and edema constitute the most frequent breast radiotherapy (RT) acute side effects. The aim of this study was to compare the predictive value of tissue-derived radiomics fea
Externí odkaz:
https://doaj.org/article/4e5acfe39a684ad5966b189a58fc2b31
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Background Reproducibility is a major concern in biomedical studies, and existing publication guidelines do not solve the problem. Batch effects and quality imbalances between groups of biological samples are major factors hampering reproduc
Externí odkaz:
https://doaj.org/article/6b9e7e93a0ba48129d1e4647399be59c
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169750 (2017)
Reconstructing the transition from a single compartment bacterium to a highly compartmentalized eukaryotic cell is one of the most studied problems of evolutionary cell biology. However, timing and details of the establishment of compartmentalization
Externí odkaz:
https://doaj.org/article/30461c2ca23047c9b0d6e0ee5322d030
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170801 (2017)
Proteins containing glutamine repeats (polyQ) are known to be structurally unstable. Abnormal expansion of polyQ in some proteins exceeding a certain threshold leads to neurodegenerative disease, a symptom of which are protein aggregates. This has le
Externí odkaz:
https://doaj.org/article/fbc00b00867b4a698462416d0dbb778a