Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Miguel A, Lanaspa"'
Autor:
Ana Andres-Hernando, David J. Orlicky, Masanari Kuwabara, Mehdi A. Fini, Dean R. Tolan, Richard J. Johnson, Miguel A. Lanaspa
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Hereditary fructose intolerance (HFI) is a painful and potentially lethal genetic disease caused by a mutation in aldolase B resulting in accumulation of fructose-1-phosphate (F1P). No cure exists for HFI and treatment is limited to avoid ex
Externí odkaz:
https://doaj.org/article/f9bcfa94f5f84ce2b5d0aa16b91d48ff
Autor:
Ana Andres-Hernando, Christina Cicerchi, Gabriela E. Garcia, David J. Orlicky, Peter Stenvinkel, Richard J. Johnson, Miguel A. Lanaspa
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106355- (2023)
Summary: Sarcopenia is a common and devastating condition in patients with chronic kidney disease (CKD). Here, we provide evidence that the kidney-muscle crosstalk in sarcopenia is mediated by reduced insulin sensitivity and the activation of the mus
Externí odkaz:
https://doaj.org/article/3b5fbfcffd0a46dd8920f4a9ce4e36c4
Autor:
Ana Andres-Hernando, David J. Orlicky, Masanari Kuwabara, Christina Cicerchi, Michelle Pedler, Mark J. Petrash, Richard J. Johnson, Dean R. Tolan, Miguel A. Lanaspa
Publikováno v:
Nutrients, Vol 15, Iss 20, p 4376 (2023)
Excessive intake of sugar, and particularly fructose, is closely associated with the development and progression of metabolic syndrome in humans and animal models. However, genetic disorders in fructose metabolism have very different consequences. Wh
Externí odkaz:
https://doaj.org/article/b02ac6a21bda49e29c4307af65de930a
Autor:
Mehdi A. Fini, Miguel A. Lanaspa, Eric A. Gaucher, Brian Boutwell, Takahiko Nakagawa, Richard M. Wright, Laura G. Sanchez-Lozada, Peter Andrews, Kurt R. Stenmark, Richard J. Johnson
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-5 (2021)
Abstract Background Recent studies suggest that fructose, as well as its metabolite, uric acid, have been associated with increased risk for both cancer incidence and growth. Both substances are known to cause oxidative stress to mitochondria and to
Externí odkaz:
https://doaj.org/article/6cf8865c41f7429f8e6c8c278ac69c75
Autor:
Gabriel Cara-Fuentes, Ana Andres-Hernando, Colin Bauer, Mindy Banks, Gabriela E. Garcia, Christina Cicerchi, Masanari Kuwabara, Michiko Shimada, Richard J. Johnson, Miguel A. Lanaspa
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104694- (2022)
Summary: Steroid-sensitive nephrotic syndrome (SSNS) in childhood is usually due to minimal change disease (MCD). Unlike many glomerular conditions, SSNS/MCD is commonly precipitated by respiratory infections. Of interest, pulmonary inflammation rele
Externí odkaz:
https://doaj.org/article/9446925e08c641d08c526c42af6dadb1
Publikováno v:
Nutrients, Vol 15, Iss 14, p 3162 (2023)
There is a worldwide epidemic of obesity and its associated metabolic dysfunction [...]
Externí odkaz:
https://doaj.org/article/db346fa858ee4753a369919bb1139c3e
Autor:
Federica Piani, Fumihiko Sasai, Petter Bjornstad, Claudio Borghi, Ashio Yoshimura, Laura G. Sanchez-Lozada, Carlos Roncal-Jimenez, Gabriela E. Garcia, Ana Andres Hernando, Gabriel Cara Fuentes, Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson
Publikováno v:
Brazilian Journal of Nephrology, Vol 43, Iss 4, Pp 572-579 (2021)
Abstract Hyperuricemia is common in chronic kidney disease (CKD) and may be present in 50% of patients presenting for dialysis. Hyperuricemia can be secondary to impaired glomerular filtration rate (GFR) that occurs in CKD. However, hyperuricemia can
Externí odkaz:
https://doaj.org/article/17dc9e9c3b2f4e41a45a0c534b40d10d
Osthole Prevents Heart Damage Induced by Diet-Induced Metabolic Syndrome: Role of Fructokinase (KHK)
Autor:
Fernando E. García-Arroyo, Guillermo Gonzaga-Sánchez, Alejandro Silva-Palacios, Francisco Javier Roldán, María L. Loredo-Mendoza, Yamnia Quetzal Alvarez-Alvarez, Jesus A. de los Santos Coyotl, Kevin A. Vélez Orozco, Edilia Tapia, Horacio Osorio-Alonso, Abraham S. Arellano-Buendía, José L. Sánchez-Gloria, Miguel A. Lanaspa, Richard J. Johnson, Laura Gabriela Sánchez-Lozada
Publikováno v:
Antioxidants, Vol 12, Iss 5, p 1023 (2023)
There is increasing evidence that either ingested or produced fructose may have a role in metabolic syndrome. While not commonly considered a criterion for metabolic syndrome, cardiac hypertrophy is often associated with metabolic syndrome, and its p
Externí odkaz:
https://doaj.org/article/35a5b79de53e41c4ab96105af334ee8d
Autor:
Ana Andres-Hernando, David J. Orlicky, Christina Cicerchi, Masanari Kuwabara, Gabriela E. Garcia, Takahiko Nakagawa, Laura Gabriela Sanchez-Lozada, Richard J. Johnson, Miguel A. Lanaspa
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 780 (2023)
The presence of obesity and metabolic syndrome is strongly linked with chronic kidney disease (CKD), but the mechanisms responsible for the association are poorly understood. Here, we tested the hypothesis that mice with obesity and metabolic syndrom
Externí odkaz:
https://doaj.org/article/3ec6a4967d224e0ca7fbc7778e645436
Autor:
Takahiko Nakagawa, Miguel A. Lanaspa, Inigo San Millan, Mehdi Fini, Christopher J. Rivard, Laura G. Sanchez-Lozada, Ana Andres-Hernando, Dean R. Tolan, Richard J. Johnson
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-12 (2020)
Abstract Obesity and metabolic syndrome are strongly associated with cancer, and these disorders may share a common mechanism. Recently, fructose has emerged as a driving force to develop obesity and metabolic syndrome. Thus, we assume that fructose
Externí odkaz:
https://doaj.org/article/28f0bb6a5bc74d3795be8b5f9ba50730