Significance of PD1 Alternative Splicing in Celiac Disease as a Novel Source for Diagnostic and Therapeutic Target

Autor: Candelaria Ponce de León, Pedro Lorite, Miguel Ángel López-Casado, Francisco Barro, Teresa Palomeque, María Isabel Torres

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

BackgroundWe have focused on the alteration of the PD-1/PD-L1 pathway in celiac disease and discussed the roles of the PD1 pathway in regulating the immune response. We explored the idea that the altered mRNA splicing process in key regulatory protei

Externí odkaz: https://doaj.org/article/6dee7a3cc9424d4b8ab00684e208b272

Identification and in vitro reactivity of celiac immunoactive peptides in an apparent gluten-free beer.

Autor: Ana Real, Isabel Comino, Ma de Lourdes Moreno, Miguel Ángel López-Casado, Pedro Lorite, Ma Isabel Torres, Ángel Cebolla, Carolina Sousa

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e100917 (2014)

Gluten content from barley, rye, wheat and in certain oat varieties, must be avoid in individuals with celiac disease. In most of the Western countries, the level of gluten content in food to be considered as gluten-free products is below 20 parts pe

Externí odkaz: https://doaj.org/article/40021c3621ec4dedbf4944c7b47cc5d0

Significance of PD1 Alternative Splicing in Celiac Disease as a Novel Source for Diagnostic and Therapeutic Target

Autor: Teresa Palomeque, Candelaria Ponce de León, María Isabel Torres, Miguel Ángel López-Casado, Pedro Lorite, Francisco Barro

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

[Background] We have focused on the alteration of the PD-1/PD-L1 pathway in celiac disease and discussed the roles of the PD1 pathway in regulating the immune response. We explored the idea that the altered mRNA splicing process in key regulatory pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327a7e114409b594d8bbfcc4090a0758
https://hdl.handle.net/10668/18158

Stimulatory Response of Celiac Disease Peripheral Blood Mononuclear Cells Induced by RNAi Wheat Lines Differing in Grain Protein Composition

Autor: Miguel Ángel López Casado, María Isabel Torres, Susana Sánchez-León, Francisco Barro, María J. Giménez, Carolina Sousa, Isabel Comino

Publikováno v: Nutrients
Volume 11
Issue 12
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)

Wheat gluten proteins are responsible for the bread-making properties of the dough but also for triggering important gastrointestinal disorders. Celiac disease (CD) affects approximately 1% of the population in Western countries. The only treatment a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e87f901560a40b12eb86a1727c908ce

Celiac Immunogenic Potential of α-Gliadin Epitope Variants from Triticum and Aegilops Species

Autor: Verónica Segura, María Isabel Torres, Carolina Sousa, Miguel Ángel López-Casado, Carmen V. Ozuna, Francisco Barro, María de Lourdes Moreno, Ángela Ruiz-Carnicer, Isabel Comino

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Nutrients, Vol 11, Iss 2, p 220 (2019)
Nutrients
Volume 11
Issue 2

The high global demand of wheat and its subsequent consumption arise from the physicochemical properties of bread dough and its contribution to the protein intake in the human diet. Gluten is the main structural complex of wheat proteins and subjects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec7162e7bcf324421b276a76c709fb4
http://hdl.handle.net/10261/177051