Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Miguel, Quiros"'
Autor:
Shusaku Hayashi, Chithra K. Muraleedharan, Makito Oku, Sunil Tomar, Simon P. Hogan, Miguel Quiros, Charles A. Parkos, Asma Nusrat
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
Acute and chronic intestinal inflammation is associated with epithelial damage, resulting in mucosal wounds in the forms of erosions and ulcers in the intestinal tract. Intestinal epithelial cells (IECs) and immune cells in the wound milieu secrete c
Externí odkaz:
https://doaj.org/article/175ef08d9ea04245a6569f22c28864f0
Autor:
Shuling Fan, Kevin Boerner, Chithra K. Muraleedharan, Asma Nusrat, Miguel Quiros, Charles A. Parkos
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Junctional adhesion molecule-A (JAM-A) is expressed in several cell types, including epithelial and endothelial cells, as well as some leukocytes. In intestinal epithelial cells (IEC), JAM-A localizes to cell junctions and plays a role in regulating
Externí odkaz:
https://doaj.org/article/9146c51e646e4f299747b38e13c56371
Autor:
Hirohito Abo, Benoit Chassaing, Akihito Harusato, Miguel Quiros, Jennifer C. Brazil, Vu L. Ngo, Emilie Viennois, Didier Merlin, Andrew T. Gewirtz, Asma Nusrat, Timothy L. Denning
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Gut microbiota and their metabolites regulate homeostasis of the intestine, but their effects on intestine development are unclear. Here the authors use RNAseq and germ free mice to show that intestinal microbiota promote the expression of Erdr1, whi
Externí odkaz:
https://doaj.org/article/041717f946814996be968b7a702f6fb1
Autor:
Michelle Reed, Anny-Claude Luissint, Veronica Azcutia, Shuling Fan, Monique N. O’Leary, Miguel Quiros, Jennifer Brazil, Asma Nusrat, Charles A. Parkos
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The role of the transmembrane glycoprotein CD47 in healing injured intestinal mucosa is unclear. Here, the authors show that selective loss of CD47 in the murine intestinal epithelium results in defective mucosal repair after colonic wounding, with s
Externí odkaz:
https://doaj.org/article/f0ca1f6c382d4838b22e30bc6b39240c
Autor:
Vicky Garcia-Hernandez, Arturo Raya-Sandino, Veronica Azcutia, Jael Miranda, Matthias Kelm, Sven Flemming, Dorothee Birkl, Miguel Quiros, Jennifer C Brazil, Charles A Parkos, Asma Nusrat
Publikováno v:
Inflammatory Bowel Diseases.
Background Incidences of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, are escalating worldwide and can be considered a global public health problem. Given that the gold standard approach to IBD therapeutics fo
Autor:
Jael Miranda, Jennifer C. Brazil, Aaron H. Morris, Charles A. Parkos, Miguel Quiros, Asma Nusrat
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Resolution of inflammation and mucosal wound healing are crucial processes required to re-establish homeostasis following injury of mucosal tissues. Maresin-2 (MaR2), a lipid specialized pro-resolving mediator derived from omega-3 polyunsaturated fat
Autor:
Anny-Claude Luissint, Francis W. Luscinskas, Asma Nusrat, Kevin Boerner, Miguel Quiros, Gail Newton, Matthias Kelm, Charles A. Parkos, Sven Flemming, Veronica Azcutia
Publikováno v:
Mucosal immunology
Dysregulated neutrophil (PMN) transmigration across epithelial surfaces (TEpM) significantly contributes to chronic inflammatory diseases, yet mechanisms defining this process remain poorly understood. In the intestine, uncontrolled PMN TEpM is a hal
Publikováno v:
J Clin Invest
Skin and intestinal epithelial barriers play a pivotal role in protecting underlying tissues from harsh external environments. The protective role of these epithelia is, in part, dependent on a remarkable capacity to restore barrier function and tiss
Autor:
Roland Hilgarth, Dorothee Birkl, Dennis W. Zhou, Mark Yulis, Matthias Bruewer, Monique N. O’ Leary, Charles A. Parkos, Jennifer C. Brazil, Asma Nusrat, Vicky Garcia-Hernandez, Justin Keeney, Andrés J. García, Miguel Quiros
Publikováno v:
Mucosal immunology
Pathobiology of several chronic inflammatory disorders, including ulcerative colitis and Crohn's disease is related to intermittent, spontaneous injury/ulceration of mucosal surfaces. Disease morbidity has been associated with pathologic release of t
Publikováno v:
Journal of visualized experiments : JoVE. (168)
The intestinal epithelium is comprised of a single layer of cells that act as a barrier between the gut lumen and the interior of the body. Disruption in the continuity of this barrier can result in inflammatory disorders such as inflammatory bowel d