Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Miguel, Mano"'
Autor:
Ines Rodrigues Lopes, Laura Maria Alcantara, Ricardo Jorge Silva, Jerome Josse, Elena Pedrero Vega, Ana Marina Cabrerizo, Melanie Bonhomme, Daniel Lopez, Frederic Laurent, Francois Vandenesch, Miguel Mano, Ana Eulalio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Staphylococcus aureus is increasingly recognized as a facultative intracellular pathogen, but it is unclear whether the intracellular lifestyle is a general feature or is restricted to some isolates. Here, Rodrigues Lopes et al. profile the interacti
Externí odkaz:
https://doaj.org/article/029b09fd0dae45dea600b08dc5edeed5
Autor:
Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract The telomeric repeat‐binding factor 2 (TRF2) is a telomere‐capping protein that plays a key role in the maintenance of telomere structure and function. It is highly expressed in different cancer types, and it contributes to cancer progre
Externí odkaz:
https://doaj.org/article/329d8d14529b400796d6b5c09e60a4e4
Autor:
Carmen Aguilar, Susana Costa, Claire Maudet, R. P. Vivek-Ananth, Sara Zaldívar-López, Juan J. Garrido, Areejit Samal, Miguel Mano, Ana Eulalio
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Cells infected with pathogens can release signals that instruct neighbouring cells to mount an immune response or that reduce these cells’ susceptibility to infection. Here, Aguilar et al. show the opposite effect: cells infected with Salmonella Ty
Externí odkaz:
https://doaj.org/article/3b6c5dc6f71647b7a9b6dbcf1c2b558f
Autor:
João Paulo Silva Nunes, Pauline Andrieux, Pauline Brochet, Rafael Ribeiro Almeida, Eduardo Kitano, André Kenji Honda, Leo Kei Iwai, Débora Andrade-Silva, David Goudenège, Karla Deysiree Alcântara Silva, Raquel de Souza Vieira, Débora Levy, Sergio Paulo Bydlowski, Frédéric Gallardo, Magali Torres, Edimar Alcides Bocchi, Miguel Mano, Ronaldo Honorato Barros Santos, Fernando Bacal, Pablo Pomerantzeff, Francisco Rafael Martins Laurindo, Priscila Camillo Teixeira, Helder I. Nakaya, Jorge Kalil, Vincent Procaccio, Christophe Chevillard, Edecio Cunha-Neto
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy (CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million people worldwide, and chronic production of the cytokines IFN-γ and TNF-α
Externí odkaz:
https://doaj.org/article/b43bed9146494db4a682bec71f6f2aff
Autor:
Ildercílio Mota de Souza Lima, Josiane Lilian dos Santos Schiavinato, Sarah Blima Paulino Leite, Danuta Sastre, Hudson Lenormando de Oliveira Bezerra, Bruno Sangiorgi, Amanda Cristina Corveloni, Carolina Hassibe Thomé, Vitor Marcel Faça, Dimas Tadeu Covas, Marco Antônio Zago, Mauro Giacca, Miguel Mano, Rodrigo Alexandre Panepucci
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-18 (2019)
Abstract Background By post-transcriptionally regulating multiple target transcripts, microRNAs (miRNAs or miR) play important biological functions. H1 embryonic stem cells (hESCs) and NTera-2 embryonal carcinoma cells (ECCs) are two of the most wide
Externí odkaz:
https://doaj.org/article/a162cd7d17324b50b3151704aca1183d
Autor:
Rebecca Bertolio, Francesco Napoletano, Miguel Mano, Sebastian Maurer-Stroh, Marco Fantuz, Alessandro Zannini, Silvio Bicciato, Giovanni Sorrentino, Giannino Del Sal
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
SREBP transcription factors activate lipid synthesis and generate raw materials to lipidate various proteins. Here, the authors show that a stiff cellular environment causes RhoA lipidation and acto-myosin contraction, which inhibits SREBP1 and conne
Externí odkaz:
https://doaj.org/article/7fe5dfbc24b447fdbd0f7459337489fa
Autor:
Hashim Ali, Miguel Mano, Luca Braga, Asma Naseem, Bruna Marini, Diem My Vu, Chiara Collesi, Germana Meroni, Marina Lusic, Mauro Giacca
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
HIV-1 integration into host DNA is mediated by the viral integrase (IN). Here, using siRNA screen and high-content microscopy, the authors identify the host E3 RING ligase TRIM33 to affect IN stability and show that TRIM33 prevents viral integration
Externí odkaz:
https://doaj.org/article/f93cc3e0668a4faa96dbc3035b454cec
Autor:
Francesca Andriani, Maria Teresa Majorini, Miguel Mano, Elena Landoni, Rosalba Miceli, Federica Facchinetti, Mavis Mensah, Enrico Fontanella, Matteo Dugo, Mauro Giacca, Ugo Pastorino, Gabriella Sozzi, Domenico Delia, Luca Roz, Daniele Lecis
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-17 (2018)
Abstract Background Fibroblasts are crucial mediators of tumor-stroma cross-talk through synthesis and remodeling of the extracellular matrix and production of multiple soluble factors. Nonetheless, little is still known about specific determinants o
Externí odkaz:
https://doaj.org/article/129bb9357c5543c1a5ce2d32753e0fd9
Autor:
Giovanni Sorrentino, Naomi Ruggeri, Alessandro Zannini, Eleonora Ingallina, Rebecca Bertolio, Carolina Marotta, Carmelo Neri, Elisa Cappuzzello, Mattia Forcato, Antonio Rosato, Miguel Mano, Silvio Bicciato, Giannino Del Sal
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Activation of YAP contributes to tumorigenesis in several tissues. Here, the authors show that in breast cancer cells glucocorticoids induce expression of fibronectin that in turn activates focal adhesion kinase/Src signalling to promote YAP nuclear
Externí odkaz:
https://doaj.org/article/afa17ad9724040a88cf693824087cda3