Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Miguel, Fidalgo"'
Publikováno v:
Architecture, Vol 4, Iss 2, Pp 303-315 (2024)
The Retirement House (1959) was a project developed by Peter Smithson that did not have the opportunity to be materialized beyond the drawing; therefore, we will use this proposal as a case study to investigate deeper into his design themes. Two text
Externí odkaz:
https://doaj.org/article/f390e6824e46457db1c42a8b25d01802
Autor:
Marcos F. Fondevila, Eva Novoa, Uxia Fernandez, Valentina Dorta, Tamara Parracho, Henriette Kreimeyer, Maria Garcia-Vence, Maria P. Chantada-Vazquez, Susana B. Bravo, Begoña Porteiro, Alba Cabaleiro, Mijra Koning, Ana Senra, Yara Souto, Joanne Verheij, Diana Guallar, Miguel Fidalgo, Abraham S. Meijnikman, Natalia da Silva Lima, Carlos Dieguez, Maria J. Gonzalez-Rellan, Ruben Nogueiras
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101962- (2024)
Objective: p63 is a transcription factor involved in multiple biological functions. In the liver, the TAp63 isoform induces lipid accumulation in hepatocytes. However, the role of liver TAp63 in the progression of metabolic dysfunction-associated ste
Externí odkaz:
https://doaj.org/article/59d4e4a6312e4306b7882162a12d2f0b
Autor:
Maria J. Gonzalez-Rellan, Tamara Parracho, Violeta Heras, Amaia Rodriguez, Marcos F. Fondevila, Eva Novoa, Natalia Lima, Marta Varela-Rey, Ana Senra, Maria D.P. Chantada-Vazquez, Cristina Ameneiro, Ganeko Bernardo, David Fernandez-Ramos, Fernando Lopitz-Otsoa, Jon Bilbao, Diana Guallar, Miguel Fidalgo, Susana Bravo, Carlos Dieguez, Maria L. Martinez-Chantar, Oscar Millet, Jose M. Mato, Markus Schwaninger, Vincent Prevot, Javier Crespo, Gema Frühbeck, Paula Iruzubieta, Ruben Nogueiras
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101776- (2023)
Objective: O-GlcNAcylation is a post-translational modification that directly couples the processes of nutrient sensing, metabolism, and signal transduction, affecting protein function and localization, since the O-linked N-acetylglucosamine moiety c
Externí odkaz:
https://doaj.org/article/534b9501b49e4a008f0846e144ff4da3
Autor:
Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Uxia Fernandez, Amaia Rodríguez, Marta Varela-Rey, Christelle Veyrat-Durebex, Samuel Seoane, Ganeko Bernardo, Fernando Lopitz-Otsoa, David Fernández-Ramos, Jon Bilbao, Cristina Iglesias, Eva Novoa, Cristina Ameneiro, Ana Senra, Daniel Beiroa, Juan Cuñarro, Maria DP Chantada-Vazquez, Maria Garcia-Vence, Susana B. Bravo, Natalia Da Silva Lima, Begoña Porteiro, Carmen Carneiro, Anxo Vidal, Sulay Tovar, Timo D. Müller, Johan Ferno, Diana Guallar, Miguel Fidalgo, Guadalupe Sabio, Stephan Herzig, Won Ho Yang, Jin Won Cho, Maria Luz Martinez-Chantar, Roman Perez-Fernandez, Miguel López, Carlos Dieguez, Jose M. Mato, Oscar Millet, Roberto Coppari, Ashwin Woodhoo, Gema Fruhbeck, Ruben Nogueiras
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
p53 regulates signalling pathways involved in metabolic homeostasis. Here the authors show that O-GlcNAcylation of p53 in the liver plays a key role in the physiological regulation of glucose homeostasis, potentially via controlling the expression of
Externí odkaz:
https://doaj.org/article/9769f87dfa1c4d5b90bfa5688f97fb4c
Autor:
Jie Lan, Nicholas Rajan, Martin Bizet, Audrey Penning, Nitesh K. Singh, Diana Guallar, Emilie Calonne, Andrea Li Greci, Elise Bonvin, Rachel Deplus, Phillip J. Hsu, Sigrid Nachtergaele, Chengjie Ma, Renhua Song, Alejandro Fuentes-Iglesias, Bouchra Hassabi, Pascale Putmans, Frédérique Mies, Gerben Menschaert, Justin J. L. Wong, Jianlong Wang, Miguel Fidalgo, Bifeng Yuan, François Fuks
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
TET mediated RNA-hydroxymethylation (5hmC) has been detected in mammals, but its physiological role remains unclear. Here the authors map 5hmC during embryonic stem cell (ESC) differentiation and find that Tet-mediated RNA hydroxymethylation reduces
Externí odkaz:
https://doaj.org/article/9305faa1ca904cdba667b6f5f1a6c75f
Autor:
Andrew J. Woo, Chelsea-Ann A. Patry, Alireza Ghamari, Gabriela Pregernig, Daniel Yuan, Kangni Zheng, Taylor Piers, Moira Hibbs, Ji Li, Miguel Fidalgo, Jenny Y. Wang, Joo-Hyeon Lee, Peter J. Leedman, Jianlong Wang, Ernest Fraenkel, Alan B. Cantor
Publikováno v:
Blood Advances, Vol 3, Iss 16, Pp 2499-2511 (2019)
Abstract: Erythroid maturation requires the concerted action of a core set of transcription factors. We previously identified the Krüppel-type zinc finger transcription factor Zfp148 (also called ZBP-89) as an interacting partner of the master eryth
Externí odkaz:
https://doaj.org/article/a4a01af35491446d8737b36cfb40774b
Publikováno v:
Cellular Reprogramming. 25:45-50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::228264a2bc23d7f3c637c500cffe4cce
https://doi.org/10.1089/cell.2023.0024
https://doi.org/10.1089/cell.2023.0024
Autor:
Sérgio Sousa, Vasco Pinto, Filipe Vaz da Silva, Tiago Ribeiro da Costa, Armindo Fernandes, Rodrigo Batata, Carolina Noronha, João Monteiro Silva, Sónia Ferreira, Salomé Sobral, Célia Alves, Rui Rangel, Alfredo Calheiros, Jorge Antunes, Miguel Fidalgo, Ana Grande, Gonçalo Figueiredo, Luís Rocha, Eduardo Cunha, Miguel Ferreira, Sérgio Moreira, Ana Machado, Márcia Tizziani, Carla Silva, Elsa Silva, Joaquim Reis, Mário Gomes, Célia Pinheiro, Dora Simões, Isabel Ribeiro, Pedro Amorim, Sara Barbeiro, Vanessa Teixeira, Sílvia Henriques, Maria Laura Gonçalves, Graça Magalhães, Ana Lacerda, Ana Paula Couto, Ana Paula Silva, Ana Ribeiro, Ana Rita Poças, Anabela Neves, Andreia Portela, Andreia Preto, Andreia Queirós, António Caeiro, Ariana Rocha, Bruna Mateus, Cristiana Pereira, Daniel Cunha, Daniela Sousa, Elsa Oliveira, Ema Paula Ribeiro, Hélder Rocha, Inês Barbosa, Inês Carvalho, Inês Cunha, Inês Lima, Inês Pires, Inês Santos, Isabel Martins, Isabel Ramos, Joana Silva, Jorge Castanheira, José Ferreira, Júlia Leitão, Juliana Silva, Leonela Margarita Torre, Lucília Alves, Manuel Sá Pinto, Margarida Lopes, Maria do Céu Amaral, Maria João Rocha Melo, Maria Monteiro, Maria Teresa Lisboa, Mariana Silva, Marília Saffarizadeh, Marisa Moreira, Marlene Luz, Noémia Costa, Patrícia Capas, Rita Quintela, Rosa Silva, Rui Neto, Rui Santos, Sílvia Silva, Simão Pinto, Sofia Queirós, Tiago Oliveira
Publikováno v:
Journal of Neurosurgery. :1-10
OBJECTIVE Timing of mobilization after chronic subdural hematoma (cSDH) surgery is highly heterogeneous among neurosurgical centers. Past studies have suggested that early mobilization may reduce medical complications without increasing recurrence, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6157a9106327ed68043b02e8c47cf9
https://doi.org/10.3171/2023.2.jns222262
https://doi.org/10.3171/2023.2.jns222262
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis. TET2 catalyzes the demethylation of 5-methylcytosine on DNA, affecting transcript
Externí odkaz:
https://doaj.org/article/fb60a33089d54f29b3d95b797fd394ef
Autor:
Alejandro Fuentes-Iglesias, Vera Garcia-Outeiral, Jose Angel Pardavila, Jianlong Wang, Miguel Fidalgo, Diana Guallar
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100093- (2020)
Summary: RNA-binding proteins are key regulators of cell identity and function, which underscores the need for unbiased and versatile protocols to identify and characterize novel protein-RNA interactions. Here, we describe a simple and cost-effective
Externí odkaz:
https://doaj.org/article/66f87f956af94b8b81d07f6132fadaeb