Staphylococcal superantigen-like protein 1 and 5 (SSL1 & SSL5) limit neutrophil chemotaxis and migration through MMP-inhibition

Autor: Carla J. C. de Haas, Adinda Bisschop, Jos A. G. van Strijp, Kirsten J. Koymans, Kok P. M. van Kessel, Mignon M. Vughs

Publikováno v: International journal of molecular sciences, 17(7). Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 17, Iss 7, p 1072 (2016)
International Journal of Molecular Sciences; Volume 17; Issue 7; Pages: 1072

Matrix metalloproteinases (MMPs) are endopeptidases that degrade components of the extracellular matrix, but also modulate inflammation. During bacterial infections, MMPs are important in the recruitment and migration of inflammatory cells. Besides f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7c90fc47370a4d283ffe080bd3f43f
https://dspace.library.uu.nl/handle/1874/345328

Pneumococcal immune evasion: ZmpC inhibits neutrophil influx

Autor: Bas G J, Surewaard, Krzysztof, Trzciński, Shamir R, Jacobino, Ivo S, Hansen, Mignon M, Vughs, Elisabeth A M, Sanders, Arie, van der Ende, Jos A G, van Strijp, Carla J C, de Haas

Publikováno v: Cellular microbiology. 15(10)

Neutrophil recruitment is essential in clearing pneumococcal infections. The first step in neutrophil extravasation involves the interaction between P-selectin on activated endothelium and P-Selectin Glycoprotein 1 (PSGL-1) on neutrophils. Here, we i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::11c101d7afe6ac95f332e1e04761563f
https://pubmed.ncbi.nlm.nih.gov/23601501

Staphylococcal superantigen-like 5 activates platelets and supports platelet adhesion under flow conditions, which involves glycoprotein Ib alpha and alpha(IIb)beta(3)

Autor: Ton Lisman, Mignon M. Vughs, de Peter Groot, C. J. C. de Haas, Cees Weeterings, J. A. G. Van Strijp

Publikováno v: Journal of Thrombosis and Haemostasis, 7(11), 1867-1874. Wiley

Objectives: Staphylococcal superantigen-like 5 (SSL5) is an exoprotein secreted by Staphylococcus aureus that has been shown to inhibit neutrophil rolling over activated endothelial cells via a direct interaction with P-selectin glycoprotein ligand 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32013213f565c6a0fce27d242151179a
https://research.rug.nl/en/publications/410766c2-7048-4f00-b9a0-7f8f08714b41