Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Migle Kazlauskiene"'
Autor:
Praveen Bawankar, Tina Lence, Chiara Paolantoni, Irmgard U. Haussmann, Migle Kazlauskiene, Dominik Jacob, Jan B. Heidelberger, Florian M. Richter, Mohanakarthik P. Nallasivan, Violeta Morin, Nastasja Kreim, Petra Beli, Mark Helm, Martin Jinek, Matthias Soller, Jean-Yves Roignant
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The E3 ligase Hakai can interact with the m6A methylation machinery but its function is still unclear. Here, the authors show that Hakai is a conserved component of the m6A methyltransferase complex and provide functional and molecular insights into
Externí odkaz:
https://doaj.org/article/fecec708c84b4bd4904def2c94ce32a6
Autor:
Irmantas Mogila, Migle Kazlauskiene, Skaiste Valinskyte, Giedre Tamulaitiene, Gintautas Tamulaitis, Virginijus Siksnys
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2753-2765.e4 (2019)
Summary: The type III-A Csm complex of Streptococcus thermophilus (StCsm) provides immunity against invading nucleic acids through the coordinated action of three catalytic domains: RNase (Csm3), ssDNase (Cas10-HD), and cyclic oligoadenylates synthas
Externí odkaz:
https://doaj.org/article/47afc86efc0440f09d5bd90817981f46
Autor:
Audronė Rukšėnaitė, Gintautas Tamulaitis, Dalia Smalakyte, Virginijus Siksnys, Auguste Rimaite, Giedre Tamulaitiene, Migle Kazlauskiene, Jesper F. Havelund, Nils J. Færgeman
Publikováno v:
Nucleic Acids Research
Nucleic acids research, Oxford : Oxford University Press, 2020, vol. 48, no. 16, p. 9204-9217
Smalakyte, D, Kazlauskiene, M, F Havelund, J, Rukšėnaitė, A, Rimaite, A, Tamulaitiene, G, Færgeman, N J, Tamulaitis, G & Siksnys, V 2020, ' Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains ', Nucleic acids research, vol. 48, no. 16, pp. 9204-9217 . https://doi.org/10.1093/nar/gkaa634
Nucleic acids research, Oxford : Oxford University Press, 2020, vol. 48, no. 16, p. 9204-9217
Smalakyte, D, Kazlauskiene, M, F Havelund, J, Rukšėnaitė, A, Rimaite, A, Tamulaitiene, G, Færgeman, N J, Tamulaitis, G & Siksnys, V 2020, ' Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains ', Nucleic acids research, vol. 48, no. 16, pp. 9204-9217 . https://doi.org/10.1093/nar/gkaa634
The type III CRISPR–Cas systems provide immunity against invading nucleic acids through the coordinated transcription-dependent DNA targeting and cyclic adenylate (cAn)-activated RNA degradation. Here, we show that both these pathways contribute to
Autor:
Mohanakarthik Ponnadai Nallasivan, Irmgard U. Haussmann, Jan B. Heidelberger, Mark Helm, Violeta Morin, Tina Lence, Migle Kazlauskiene, Nastasja Kreim, Jean-Yves Roignant, Florian Richter, Chiara Paolantoni, Dominik Jacob, Martin Jinek, Matthias Soller, Petra Beli, Praveen Bawankar
Publikováno v:
Nature communications, vol. 12, no. 1, pp. 3778
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
N6-methyladenosine (m6A) is the most abundant internal modification on mRNA which influences most steps of mRNA metabolism and is involved in several biological functions. The E3 ubiquitin ligase Hakai was previously found in complex with components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9197b6a2a94e349753dc169b857c253
https://serval.unil.ch/notice/serval:BIB_C0C803938C71
https://serval.unil.ch/notice/serval:BIB_C0C803938C71
Autor:
Egidijus Kazlauskas, Lina Baranauskiene, Visvaldas Kairys, Migle Kazlauskiene, Daumantas Matulis
Publikováno v:
Expert Opinion on Drug Discovery. 14:755-768
Introduction: In pharmaceutical design where future drugs are developed by targeting a specific chosen protein, the evaluation of ligand affinity is crucial. For this very purpose are a multitude of diverse methods which are continuously being improv
Autor:
Praveen, Bawankar, Tina, Lence, Chiara, Paolantoni, Irmgard U, Haussmann, Migle, Kazlauskiene, Dominik, Jacob, Jan B, Heidelberger, Florian M, Richter, Mohanakarthik P, Nallasivan, Violeta, Morin, Nastasja, Kreim, Petra, Beli, Mark, Helm, Martin, Jinek, Matthias, Soller, Jean-Yves, Roignant
Publikováno v:
Nature Communications
N6-methyladenosine (m6A) is the most abundant internal modification on mRNA which influences most steps of mRNA metabolism and is involved in several biological functions. The E3 ubiquitin ligase Hakai was previously found in complex with components
Autor:
Migle Kazlauskiene, Skaiste Valinskyte, Gintautas Tamulaitis, Virginijus Siksnys, Irmantas Mogila, Giedre Tamulaitiene
Publikováno v:
Cell reports, Cambridge, MA : Cell Press, 2019, vol. 26, no. 10, p. 2753-2765
Cell Reports, Vol 26, Iss 10, Pp 2753-2765.e4 (2019)
Cell Reports, Vol 26, Iss 10, Pp 2753-2765.e4 (2019)
Summary: The type III-A Csm complex of Streptococcus thermophilus (StCsm) provides immunity against invading nucleic acids through the coordinated action of three catalytic domains: RNase (Csm3), ssDNase (Cas10-HD), and cyclic oligoadenylates synthas
Autor:
Gintautas Tamulaitis, Migle Kazlauskiene, Elena Manakova, Česlovas Venclovas, Alison O. Nwokeoji, Mark J. Dickman, Philippe Horvath, Virginijus Siksnys
Publikováno v:
Molecular Cell. 56(4):506-517
Immunity against viruses and plasmids provided by CRISPR-Cas systems relies on a ribonucleoprotein effector complex that triggers the degradation of invasive nucleic acids (NA). Effector complexes of type I (Cascade) and II (Cas9-dual RNA) target for
Autor:
Česlovas Venclovas, Virginijus Siksnys, Gintautas Tamulaitis, Georgij Kostiuk, Migle Kazlauskiene
Publikováno v:
Science (New York, N.Y.). 357(6351)
Type III CRISPR-Cas systems in prokaryotes provide immunity against invading nucleic acids through the coordinated degradation of transcriptionally active DNA and its transcripts by the Csm effector complex. The Cas10 subunit of the complex contains
Autor:
Česlovas Venclovas, Georgij Kostiuk, Gintautas Tamulaitis, Virginijus Siksnys, Migle Kazlauskiene
Publikováno v:
Molecular cell. 62(2)
Streptococcus thermophilus (St) type III-A CRISPR-Cas system restricts MS2 RNA phage and cuts RNA in vitro. However, the CRISPR array spacers match DNA phages, raising the question: does the St CRISPR-Cas system provide immunity by erasing phage mRNA