Enhanced vaccine-induced CD8+ T cell responses to malaria antigen ME-TRAP by fusion to MHC class ii invariant chain.

Autor: Alexandra J Spencer, Matthew G Cottingham, Jennifer A Jenks, Rhea J Longley, Stefania Capone, Stefano Colloca, Antonella Folgori, Riccardo Cortese, Alfredo Nicosia, Migena Bregu, Adrian V S Hill

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e100538 (2014)

The orthodox role of the invariant chain (CD74; Ii) is in antigen presentation to CD4+ T cells, but enhanced CD8+ T cells responses have been reported after vaccination with vectored viral vaccines encoding a fusion of Ii to the antigen of interest.

Externí odkaz: https://doaj.org/article/03a908736103413081ed60360973a6cb

Identification of 34 novel proinflammatory proteins in a genome-wide macrophage functional screen.

Autor: David H Wyllie, Karen C Søgaard, Karen Holland, Xu Yaobo, Migena Bregu, Adrian V S Hill, Endre Kiss-Toth

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e42388 (2012)

Signal transduction pathways activated by Toll-like Receptors and the IL-1 family of cytokines are fundamental to mounting an innate immune response and thus to clearing pathogens and promoting wound healing. Whilst mechanistic understanding of the r

Externí odkaz: https://doaj.org/article/9f453e042ae14fb0bfe2ffb991a6125f

Development of a molecular adjuvant to enhance antigen-specific CD8+ T cell responses

Autor: Benedict R. Halbroth, Sarah Sebastian, Hazel C. Poyntz, Migena Bregu, Matthew G. Cottingham, Adrian V. S. Hill, Alexandra J. Spencer

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)

Despite promising progress in malaria vaccine development, an efficacious subunit vaccine against P. falciparum remains to be licensed and deployed. This study aimed to improve on the immunogenicity of the leading liver-stage vaccine candidate (ChAd6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6386b9e09a8c5a1707449a047bb1c061
http://ora.ox.ac.uk/objects/uuid:

Unlinking chromosome catenanes in vivo by site-specific recombination

Autor: Migena Bregu, Ian Grainge, Mariel Vazquez, Viknesh Sivanathan, David J. Sherratt, Stephen C.Y. Ip

Publikováno v: The EMBO journal, vol 26, iss 19
Grainge, I; Bregu, M; Vazquez, M; Sivanathan, V; Ip, SC; & Sherratt, DJ. (2018). Unlinking chromosome catenanes in vivo by site-specific recombination.. The EMBO Journal. UC Davis: Department of Mathematics. Retrieved from: http://www.escholarship.org/uc/item/67f779w5

A challenge for chromosome segregation in all domains of life is the formation of catenated progeny chromosomes, which arise during replication as a consequence of the interwound strands of the DNA double helix. Topoisomerases play a key role in DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df424280e605ca747d0e4681526a659
https://ora.ox.ac.uk/objects/uuid:67e61ef6-e573-47d6-a948-f71cbcfff08b

Accelerating vaccine development and deployment: report of a Royal Society satellite meeting

Autor: Brian Greenwood, Simon J. Draper, Migena Bregu, Adrian V. S. Hill

Publikováno v: Philosophical Transactions of the Royal Society B: Biological Sciences

The Royal Society convened a meeting on the 17th and 18th November 2010 to review the current ways in which vaccines are developed and deployed, and to make recommendations as to how each of these processes might be accelerated. The meeting brought t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670d57d3cfcc74d256bec20dba99ff78