Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Miezan J. Ezoulin"'
Autor:
Bi-Botti C. Youan, Navid J. Ayon, Nathan A. Oyler, Miezan J. Ezoulin, Sudhaunshu S. Purohit, Fohona S. Coulibaly
Publikováno v:
Molecular Pharmaceutics. 14:3512-3527
The purpose of this study is to engineer a model anti-HIV microbicide (Tenofovir) drug delivery system targeting HIV-1 envelope glycoprotein gp120 (HIV-1 g120) for the prevention of HIV sexual transmission. HIV-1 g120 and mannose responsive particles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c039319e81a9c28b7a332d51a7adb6
https://doi.org/10.1021/acs.molpharmaceut.7b00555
https://doi.org/10.1021/acs.molpharmaceut.7b00555
Publikováno v:
Molecular pharmaceutics. 16(2)
Many novel vaginal/rectal microbicide formulations failed clinically due to safety concerns, indicating the need for the early investigation of lead microbicide formulations. In this study, the preclinical safety of an HIV-1 gp120 and mannose respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ecec5ad0625ef8b59b17edf6cddc8bf
https://pubmed.ncbi.nlm.nih.gov/30525661
https://pubmed.ncbi.nlm.nih.gov/30525661
Autor:
Vivek Agrahari, Chi Zhang, Daniel C. Dim, Miezan J. Ezoulin, Bi Botti C. Youan, Agostino Molteni, Jianing Meng, Sudhaunshu S. Purohit, Nathan A. Oyler
Publikováno v:
Molecular Pharmaceutics. 13:4129-4140
It is hypothesized that thiolated chitosan (TCS) core/shell nanofibers (NFs) can enhance the drug loading of tenofovir, a model low molecular weight and highly water-soluble drug molecule, and improve its mucoadhesivity and in vivo safety. To test th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06656b16dbecbbcc783870c9b7add38b
https://doi.org/10.1021/acs.molpharmaceut.6b00739
https://doi.org/10.1021/acs.molpharmaceut.6b00739
Publikováno v:
Pharmaceutical Research. 33:367-383
It is hypothesized that sodium acetate (SA) can be used for in situ coating of drug loaded chitosan NPs for improved physico-chemical properties. Tenofovir (TFV) is used as a model drug. Uncoated chitosan NPs are prepared by ionic gelation. SA is gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7942d0d82eeeaaacac3ebc3b75f9bc1
https://doi.org/10.1007/s11095-015-1795-y
https://doi.org/10.1007/s11095-015-1795-y
Publikováno v:
Nanomedicine. 9:1595-1612
Aim: This study is designed to test the hypothesis that tenofovir-loaded (an anti-HIV microbicide) chitosan–thioglycolic acid-conjugated (CS–TGA) nanoparticles (NPs) exhibit superior biophysical properties for mucoadhesion compared with those of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f20cbea6f99933447f79a27058ad060
https://doi.org/10.2217/nnm.13.136
https://doi.org/10.2217/nnm.13.136
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 118:234-242
The present work aimed to investigate the suitability of polymeric nanoparticles (NPs) loaded with resveratrol (RES) for drug delivery to cochlear cells. RES-loaded NPs were prepared by a solvent-diffusion method without surfactant. The Box-Behnken d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8773c8b89a7dd259685dc61b445672
https://doi.org/10.1016/j.colsurfb.2014.03.054
https://doi.org/10.1016/j.colsurfb.2014.03.054
Autor:
Miezan J. Ezoulin, Wei-Ting Hung, Ibrahima Youm, Bi-Botti C. Youan, Daniel C. Dim, Lane K. Christenson, Vivek Agrahari, Agostino Molteni, Jianing Meng
Publikováno v:
Nanomedicine (Lond)
Aim: To develop a seminal enzyme bioresponsive, mucoadhesive nanofibers (NFs) as safe and effective nanocarriers for the prevention of HIV vaginal transmission. Methods: A novel thiolated hyaluronic acid (HA-SH) polymer was synthesized to fabricate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b452dd20247c4f8c7f87489448df96fb
https://europepmc.org/articles/PMC9816923/
https://europepmc.org/articles/PMC9816923/
Autor:
Vivek Agrahari, Sudhaunshu S. Purohit, Jianing Meng, Bi-Botti C. Youan, Daniel C. Dim, Nathan A. Oyler, Agostino Molteni, Tao Zhang, Miezan J. Ezoulin
Publikováno v:
The AAPS journal. 19(3)
It is hypothesized that novel thiolated chitosan-coated multilayer microparticles (MPs) with enhanced drug loading are more mucoadhesive than uncoated MPs and safe in vivo for vaginal delivery of topical anti-HIV microbicide. Formulation optimization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4955fc95754dc5a96c5b36a53f593bb6
https://pubmed.ncbi.nlm.nih.gov/28138910
https://pubmed.ncbi.nlm.nih.gov/28138910
Publikováno v:
Journal of Analytical & Bioanalytical Techniques. 5
For low protein concentrations containing biological samples (in proteomics) and for non proteinaceous compound assays (in bioanalysis), there is a critical need for a simple, fast, and cost-effective protein enrichment or precipitation method. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8ba74a72224e17e27582b4a8c01140
https://doi.org/10.4172/2155-9872.1000198
https://doi.org/10.4172/2155-9872.1000198