Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mietha M. van der Walt"'
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-6 (2023)
Abstract Objective To ensure reproducibility in biomedical research, the biological variable sex must be reported; yet a reason for using male (instead of female) rodents is seldom given. In our search for novel adenosine receptor ligands, our resear
Externí odkaz:
https://doaj.org/article/ce0adf95f77e4ce99f2d4a5ada522cf0
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT The highly adaptive cellular response of Mycobacterium tuberculosis to various antibiotics and the high costs for clinical trials, hampers the development of novel antimicrobial agents with improved efficacy and safety. Subsequently, in sili
Externí odkaz:
https://doaj.org/article/9724d5a05dcb469a8d2e9bd77c097e10
Objective: To ensure reproducibility in biomedical research, the biological variable sex must be reported; yet a reason for using male (instead of female) rodents is seldom given. In our search for novel adenosine receptor ligands, our research group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58c6984b43159f498f7d3586a46aa7d
https://doi.org/10.21203/rs.3.rs-1953772/v1
https://doi.org/10.21203/rs.3.rs-1953772/v1
Publikováno v:
Microbiology Spectrum. 10
This article elaborates on the mechanism of action of a novel antibiotic compound against both, active and dormantMycobacterium tuberculosisand describes its pharmacokinetics (including oral bioavailability and toxicity). Information provided in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ae548f5589393ff4c1aa49857be74d1
https://doi.org/10.1128/spectrum.02315-21
https://doi.org/10.1128/spectrum.02315-21
The highly adaptive cellular response of Mycobacterium tuberculosis to various antibiotics and the high costs for clinical trials, hampers the development of novel antimicrobial agents with improved efficacy and safety. Subsequently, in silico drug s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecf0ea6cdaad6c2816458863ee01ba42
https://doi.org/10.1101/2021.11.17.469062
https://doi.org/10.1101/2021.11.17.469062
Autor:
Helena D. Janse van Rensburg, Mietha M. Van der Walt, Lesetja J. Legoabe, Gisella Terre’Blanche
Publikováno v:
MedChemComm. 10:300-309
A prior study reported on hydroxy substituted 2-benzylidene-1-indanone derivatives as A(1) and/or A(2A) antagonists for the potential treatment of neurological conditions. A lead compound (1a) was identified with both A(1) and A(2A) affinity in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290d9d6a0a5665715077c41920f6a699
https://doi.org/10.1039/c8md00540k
https://doi.org/10.1039/c8md00540k
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(16)
Antagonists of the adenosine receptors (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f64ec4d83e1b8301a7d017c5e0e6085
https://pubmed.ncbi.nlm.nih.gov/32631506
https://pubmed.ncbi.nlm.nih.gov/32631506
Publikováno v:
Bioorganic Chemistry. 77:136-143
Adenosine receptor antagonists are under investigation as potential drug candidates for the treatment of certain cancers, neurological disorders, depression and potentially improve tumour immunotherapy. The benzo-γ-pyrone scaffold is well-known in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a770f529597812535a9d1f9db5b6ec
https://doi.org/10.1016/j.bioorg.2018.01.004
https://doi.org/10.1016/j.bioorg.2018.01.004
Publikováno v:
Chemical Biology & Drug Design. 91:234-244
Antagonists of the adenosine receptors (A1 and A2A ) are thought to be beneficial in neurological disorders, such as Alzheimer's and Parkinson's disease. The aim of this study was to explore 2-benzylidene-1-tetralone derivatives as antagonists of A1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68da48851295ccd3fb4548a12e0f6d53
https://doi.org/10.1111/cbdd.13074
https://doi.org/10.1111/cbdd.13074
Autor:
Mietha M. Van der Walt, Lesetja J. Legoabe, Gisella Terre’Blanche, Helena D. Janse van Rensburg
Publikováno v:
Drug research. 69(7)
Previous studies explored 2-benzylidine-1-tetralone derivatives as innovative adenosine A1 and A2A receptor antagonists for alternative non-dopaminergic treatment of Parkinson’s disease. This study’s aim is to investigate structurally related 2-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5851134972f314cdb8b44dab352c7df4
https://pubmed.ncbi.nlm.nih.gov/30616250
https://pubmed.ncbi.nlm.nih.gov/30616250