GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation

Autor: Drube, J., Haider, R. S., Matthees, E. S. F., Reichel, M., Zeiner, J., Fritzwanker, S., Ziegler, C., Barz, S., Klement, L., Filor, J., Weitzel, V., Kliewer, A., Miess-Tanneberg, E., Kostenis, E., Schulz, S., Hoffmann, C.

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Nature Communications

G protein-coupled receptors (GPCRs) activate G proteins and undergo a complex regulation by interaction with GPCR kinases (GRKs) and the formation of receptor–arrestin complexes. However, the impact of individual GRKs on arrestin binding is not cle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::baccbb119a8f48faf0fb270cde952778
https://doaj.org/article/330be478d5f2425eb5c6a61f25b74a46

How Carvedilol activates β 2 -adrenoceptors.

Autor: Benkel T; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany.; Research Training Group 1873, University of Bonn, 53127, Bonn, Germany., Zimmermann M; InterAx Biotech AG, 5234, Villigen, Switzerland., Zeiner J; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany., Bravo S; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany., Merten N; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany., Lim VJY; Department of Pharmaceutical Chemistry, Philipps-University of Marburg, 35032, Marburg, Germany., Matthees ESF; Institute for Molecular Cell Biology, CMB-Center for Molecular Biomedicine, Jena University Hospital, Friedrich Schiller University of Jena, 07745, Jena, Germany., Drube J; Institute for Molecular Cell Biology, CMB-Center for Molecular Biomedicine, Jena University Hospital, Friedrich Schiller University of Jena, 07745, Jena, Germany., Miess-Tanneberg E; Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University of Jena, 07747, Jena, Germany., Malan D; Institute of Physiology I, Medical Faculty, University of Bonn, 53115, Bonn, Germany., Szpakowska M; Department of Infection and Immunity, Luxembourg Institute of Health (LIH), L-4354, Esch-sur-Alzette, Luxembourg., Monteleone S; Department of Pharmaceutical Chemistry, Philipps-University of Marburg, 35032, Marburg, Germany., Grimes J; Institute of Metabolism and Systems Research and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, B15 2TT, UK., Koszegi Z; Institute of Metabolism and Systems Research and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, B15 2TT, UK., Lanoiselée Y; Institute of Metabolism and Systems Research and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, B15 2TT, UK., O'Brien S; Institute of Metabolism and Systems Research and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, B15 2TT, UK., Pavlaki N; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany., Dobberstein N; InterAx Biotech AG, 5234, Villigen, Switzerland., Inoue A; Graduate School of Pharmaceutical Science, Tohoku University, Sendai, 980-8578, Japan., Nikolaev V; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany., Calebiro D; Institute of Metabolism and Systems Research and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, B15 2TT, UK., Chevigné A; Department of Infection and Immunity, Luxembourg Institute of Health (LIH), L-4354, Esch-sur-Alzette, Luxembourg., Sasse P; Institute of Physiology I, Medical Faculty, University of Bonn, 53115, Bonn, Germany., Schulz S; Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University of Jena, 07747, Jena, Germany.; 7TM Antibodies GmbH, 07745, Jena, Germany., Hoffmann C; Institute for Molecular Cell Biology, CMB-Center for Molecular Biomedicine, Jena University Hospital, Friedrich Schiller University of Jena, 07745, Jena, Germany., Kolb P; Department of Pharmaceutical Chemistry, Philipps-University of Marburg, 35032, Marburg, Germany., Waldhoer M; InterAx Biotech AG, 5234, Villigen, Switzerland.; Ikherma Consulting Ltd, Hitchin, SG4 0TY, UK., Simon K; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany., Gomeza J; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany., Kostenis E; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany. kostenis@uni-bonn.de.

Publikováno v: Nature communications [Nat Commun] 2022 Nov 19; Vol. 13 (1), pp. 7109. Date of Electronic Publication: 2022 Nov 19.

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Allosteric Regulation of G-Protein-Coupled Receptors: From Diversity of Molecular Mechanisms to Multiple Allosteric Sites and Their Ligands.

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Publikováno v: International Journal of Molecular Sciences. Apr2023, Vol. 24 Issue 7, p6187. 54p.

G Protein-Coupled Receptors: A Century of Research and Discovery.

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