Rational correction of pathogenic conformational defects in HTRA1.

Autor: Beaufort N; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Ingendahl L; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Merdanovic M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Schmidt A; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Graduate School of Systemic Neurosciences (GSN), LMU Munich, Munich, Germany., Podlesainski D; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Richter T; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Neumann T; Organic Chemistry, Faculty of Chemistry, University Duisburg-Essen, Essen, Germany., Kuszner M; Center of Medical Biotechnology, Faculty of Chemistry, University Duisburg-Essen, Essen, Germany., Vetter IR; Max-Planck-Institute of Molecular Physiology, Dortmund, Germany., Stege P; Max-Planck-Institute of Molecular Physiology, Dortmund, Germany., Burston SG; School of Biochemistry, University of Bristol, Biomedical Sciences Building, Bristol, UK., Filipovic A; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Ruiz-Blanco YB; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Bravo-Rodriguez K; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.; Max-Planck-Institute of Molecular Physiology, Dortmund, Germany., Mieres-Perez J; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.; Department of Biochemical and Chemical Engineering, Technical University Dortmund, Dortmund, Germany., Beuck C; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Uebel S; Max-Planck-Institute of Biochemistry, Martinsried, Germany., Zobawa M; Max-Planck-Institute of Biochemistry, Martinsried, Germany., Schillinger J; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Todorov-Völgyi K; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Rey J; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Roberti A; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Hagemeier B; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Wefers B; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute of Developmental Genetics (IDG), Helmholtz Zentrum München, Neuherberg, Germany., Müller SA; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Wurst W; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute of Developmental Genetics (IDG), Helmholtz Zentrum München, Neuherberg, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Technische Universität München-Weihenstephan, Freising, Germany., Sanchez-Garcia E; Department of Biochemical and Chemical Engineering, Technical University Dortmund, Dortmund, Germany., Zimmermann A; Center of Medical Biotechnology, Faculty of Chemistry, University Duisburg-Essen, Essen, Germany., Hu XY; College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, China., Clausen T; Research Institute of Molecular Pathology (IMP), Vienna, Austria., Huber R; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.; Max-Planck-Institute of Biochemistry, Martinsried, Germany., Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Schmuck C; Center of Medical Biotechnology, Faculty of Chemistry, University Duisburg-Essen, Essen, Germany., Giese M; Organic Chemistry, Faculty of Chemistry, University Duisburg-Essen, Essen, Germany., Kaiser M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Ehrmann M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany. Michael.Ehrmann@uni-due.de., Dichgans M; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany. dichgansmartin@gmail.com.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. dichgansmartin@gmail.com.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. dichgansmartin@gmail.com.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 16; Vol. 15 (1), pp. 5944. Date of Electronic Publication: 2024 Jul 16.

Chirality control of a single carbene molecule by tip-induced van der Waals interactions.

Autor: Cao Y; Physical Chemistry I, Ruhr-Universität Bochum, Universitätsstr. 150, D-44801, Bochum, Germany., Mieres-Perez J; Computational Bioengineering, Technical University Dortmund, Emil-Figge-Str. 66, 44227, Dortmund, Germany.; Computational Biochemistry, Universität Duisburg-Essen, Universitätsstr. 2, D-45141, Essen, Germany., Rowen JF; Organic Chemistry II, Ruhr-Universität Bochum, Universitätsstr. 150, D-44801, Bochum, Germany., Sanchez-Garcia E; Computational Bioengineering, Technical University Dortmund, Emil-Figge-Str. 66, 44227, Dortmund, Germany.; Computational Biochemistry, Universität Duisburg-Essen, Universitätsstr. 2, D-45141, Essen, Germany., Sander W; Organic Chemistry II, Ruhr-Universität Bochum, Universitätsstr. 150, D-44801, Bochum, Germany., Morgenstern K; Physical Chemistry I, Ruhr-Universität Bochum, Universitätsstr. 150, D-44801, Bochum, Germany. karina.morgenstern@rub.de.

Publikováno v: Nature communications [Nat Commun] 2023 Jul 26; Vol. 14 (1), pp. 4500. Date of Electronic Publication: 2023 Jul 26.

C-C Coupling of Carbene Molecules on a Metal Surface in the Presence of Water.

Autor: Cao Y; Ruhr-Universität Bochum, Lehrstuhl für Physikalische Chemie I, Universitätsstr. 150, Bochum D-44801, Germany., Mieres-Perez J; Technische Universität Dortmund, Lehrstuhl für Computational Bioengineering, Dortmund 44227, Germany., Lucht K; Ruhr-Universität Bochum, Lehrstuhl für Physikalische Chemie I, Universitätsstr. 150, Bochum D-44801, Germany., Ulrich I; Ruhr-Universität Bochum, Lehrstuhl für Organische Chemie II, Universitätsstr. 150, Bochum D-44801, Germany., Schweer P; Ruhr-Universität Bochum, Lehrstuhl für Physikalische Chemie I, Universitätsstr. 150, Bochum D-44801, Germany., Sanchez-Garcia E; Technische Universität Dortmund, Lehrstuhl für Computational Bioengineering, Dortmund 44227, Germany., Morgenstern K; Ruhr-Universität Bochum, Lehrstuhl für Physikalische Chemie I, Universitätsstr. 150, Bochum D-44801, Germany., Sander W; Ruhr-Universität Bochum, Lehrstuhl für Organische Chemie II, Universitätsstr. 150, Bochum D-44801, Germany.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 May 31; Vol. 145 (21), pp. 11544-11552. Date of Electronic Publication: 2023 May 19.

Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses.

Autor: Weil T; Institute of Molecular Virology, Ulm University Medical Center, Ulm89081, Germany., Kirupakaran A; Faculty of Chemistry, University of Duisburg-Essen, Essen45117, Germany., Le MH; Faculty of Chemistry, University of Duisburg-Essen, Essen45117, Germany., Rebmann P; Faculty of Chemistry, University of Duisburg-Essen, Essen45117, Germany., Mieres-Perez J; Computational Biochemistry, University of Duisburg-Essen, Essen45117, Germany., Issmail L; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig04103, Germany., Conzelmann C; Institute of Molecular Virology, Ulm University Medical Center, Ulm89081, Germany., Müller JA; Institute of Virology, Philipps University of Marburg, Marburg35043, Germany., Rauch L; Institute of Molecular Virology, Ulm University Medical Center, Ulm89081, Germany., Gilg A; Institute of Molecular Virology, Ulm University Medical Center, Ulm89081, Germany., Wettstein L; Institute of Molecular Virology, Ulm University Medical Center, Ulm89081, Germany., Groß R; Institute of Molecular Virology, Ulm University Medical Center, Ulm89081, Germany., Read C; Central Facility for Electron Microscopy, Ulm University, Ulm89081, Germany.; Institute of Virology, Ulm University Medical Center, Ulm89081, Germany., Bergner T; Central Facility for Electron Microscopy, Ulm University, Ulm89081, Germany., Pålsson SA; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm10691, Sweden., Uhlig N; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig04103, Germany., Eberlein V; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig04103, Germany., Wöll H; Faculty of Chemistry, University of Duisburg-Essen, Essen45117, Germany., Klärner FG; Faculty of Chemistry, University of Duisburg-Essen, Essen45117, Germany., Stenger S; Institute for Microbiology and Hygiene, Ulm University Medical Center, Ulm89081, Germany., Kümmerer BM; Institute of Virology, Medical Faculty, University of Bonn, Bonn53127, Germany.; German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Bonn53127, Germany., Streeck H; Institute of Virology, Medical Faculty, University of Bonn, Bonn53127, Germany.; German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Bonn53127, Germany., Fois G; Institute of General Physiology, Ulm University, Ulm89081, Germany., Frick M; Institute of General Physiology, Ulm University, Ulm89081, Germany., Braubach P; Institute of Pathology, Hannover Medical School (MHH), Hannover30625, Germany., Spetz AL; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm10691, Sweden., Grunwald T; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig04103, Germany., Shorter J; Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia19104, United States., Sanchez-Garcia E; Computational Biochemistry, University of Duisburg-Essen, Essen45117, Germany., Schrader T; Faculty of Chemistry, University of Duisburg-Essen, Essen45117, Germany., Münch J; Institute of Molecular Virology, Ulm University Medical Center, Ulm89081, Germany.

Publikováno v: JACS Au [JACS Au] 2022 Sep 06; Vol. 2 (9), pp. 2187-2202. Date of Electronic Publication: 2022 Sep 06 (Print Publication: 2022).

An allosteric HTRA1-calpain 2 complex with restricted activation profile.

Autor: Rey J; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany., Breiden M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany., Lux V; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany., Bluemke A; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany., Steindel M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany., Ripkens K; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany., Möllers B; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany., Bravo Rodriguez K; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany., Boisguerin P; PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier Cedex 5, France., Volkmer R; Institut für Medizinische Immunologie, Charité - Universitätsmedizin Berlin, 10115 Berlin, Germany., Mieres-Perez J; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany., Clausen T; Research Institute of Molecular Pathology - IMP, 1030 Vienna, Austria., Sanchez-Garcia E; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany., Ehrmann M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.; School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Apr 05; Vol. 119 (14), pp. e2113520119. Date of Electronic Publication: 2022 Mar 29.