Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mieke Veltman"'
Autor:
Julien Slagboom, Abigail H. Lewis, Wietse M. Schouten, Rien van Haperen, Mieke Veltman, Mátyás A. Bittenbinder, Freek J. Vonk, Nicholas R. Casewell, Frank Grosveld, Dubravka Drabek, Jeroen Kool
Publikováno v:
Toxicon: X, Vol 21, Iss , Pp 100185- (2024)
Snakebite envenoming is a priority Neglected Tropical Disease that causes an estimated 81,000–135,000 fatalities each year. The development of a new generation of safer, affordable, and accessible antivenom therapies is urgently needed. With this g
Externí odkaz:
https://doaj.org/article/aa72a3429ba844ee87def2003bd12c3d
Autor:
Sylvia Merkert, Madline Schubert, Ruth Olmer, Lena Engels, Silke Radetzki, Mieke Veltman, Bob J. Scholte, Janina Zöllner, Nicoletta Pedemonte, Luis J.V. Galietta, Jens P. von Kries, Ulrich Martin
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1389-1403 (2019)
Summary: Organotypic culture systems from disease-specific induced pluripotent stem cells (iPSCs) exhibit obvious advantages compared with immortalized cell lines and primary cell cultures, but implementation of iPSC-based high-throughput (HT) assays
Externí odkaz:
https://doaj.org/article/04385feafd36439896964d1362645101
Autor:
Mieke Veltman, Juan B. De Sanctis, Marta Stolarczyk, Nikolai Klymiuk, Andrea Bähr, Rutger W. Brouwer, Edwin Oole, Juhi Shah, Tomas Ozdian, Jie Liao, Carolina Martini, Danuta Radzioch, John W. Hanrahan, Bob J. Scholte
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
A deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) function in CF leads to chronic lung disease. CF is associated with abnormalities in fatty acids, ceramides, and cholesterol, their relationship with CF lung pathology is not
Externí odkaz:
https://doaj.org/article/dab84d6131704fe695331985e9e0b018
Autor:
Camilla Margaroli, Hamed Horati, Luke W. Garratt, Vincent D. Giacalone, Craig Schofield, A. Susanne Dittrich, Tim Rosenow, Brian S. Dobosh, Hong S. Lim, Dario L. Frey, Mieke Veltman, George L. Silva, Milton R. Brown, Carsten Schultz, Harm A.W.M. Tiddens, Sarath Ranganathan, Joshua D. Chandler, Peng Qiu, Limin Peng, Bob J. Scholte, Marcus A. Mall, Anthony Kicic, Lokesh Guglani, Stephen M. Stick, Hettie M. Janssens, Rabindra Tirouvanziam
Publikováno v:
Journal of Cystic Fibrosis, 21(6), 967-976. Elsevier
Background: Macrophages are the major resident immune cells in human airways coordinating responses to infection and injury. In cystic fibrosis (CF), neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzyme
Autor:
Kari-Pekka Skarp, Robbert J. Rottier, Gabriela G Edel, Iriondo Cinta, Mieke Veltman, Bob J. Scholte, Anne Boerema-de Munck, Rene M. H. Wijnen, Marjon Buscop-van Kempen
Publikováno v:
Paediatric lung cell and molecular biology.
Autor:
Mieke Veltman, Guido Veit, Marta Stolarczyk, Bob J. Scholte, Andrea Schnúr, Gergely L. Lukacs
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 314(4), 1555-1568. American Physiological Society
The EGF receptor (EGFR)/a disintegrin and metalloproteinase 17 (ADAM17) signaling pathway mediates the shedding of growth factors and secretion of cytokines and is involved in chronic inflammation and tissue remodeling. Since these are hallmarks of c
Autor:
Bob J. Scholte, Young-Mi Go, Hamed Horati, Joshua D. Chandler, Hettie M. Janssens, Mieke Veltman, Dean P. Jones, Douglas I. Walker, Enea Pagliano, Rabindra Tirouvanziam
Publikováno v:
Free Radical Biology and Medicine, 126, 334-340. Elsevier Inc.
Thiocyanate is a heme peroxidase substrate that scavenges oxidants produced during inflammation and regulates host defense. In cystic fibrosis (CF) patients, increased airway thiocyanate levels are associated with improved lung function. Research on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c86e6223aa101d741b26f8d2d726315
https://europepmc.org/articles/PMC6166650/
https://europepmc.org/articles/PMC6166650/
Autor:
Bob J. Scholte, Mieke Veltman, Camilla Margaroli, Harm A.W.M. Tiddens, Karan Uppal, Joshua D. Chandler, Lokesh Guglani, Rabindra Tirouvanziam, Dean P. Jones, Limin Peng, H. Ken Liu, Alexander J. Taurone, Young-Mi Go, Matthew B. Kilgore, Hettie M. Janssens, Hamed Horati
Publikováno v:
European Respiratory Journal, 52(4):1801118. European Respiratory Society
Cystic fibrosis (CF) lung disease progressively worsens from infancy to adulthood. Disease-driven changes in early CF airway fluid metabolites may identify therapeutic targets to curb progression.CF patients aged 12–38 months (n=24; three out of 24
Autor:
Tamas Oravecz, Bob J. Scholte, Danuta Radzioch, Oleh Dzyubachyk, Gabriella Wojewodka, Marta Stolarczyk, Ismé de Kleer, Mieke Veltman, Juan B. De Sanctis, Willem A. Dik
Publikováno v:
AJP-Lung Cellular and Molecular Physiology, 311(5), L1000-L1014
American Journal of Physiology-Lung Cellular and Molecular Physiology, 311(5), L1000-L1014. American Physiological Society
American Journal of Physiology-Lung Cellular and Molecular Physiology, 311(5), L1000-L1014. American Physiological Society
Progressive lung disease with early onset is the main cause of mortality and morbidity in cystic fibrosis patients. Here we report a reduction of sphingosine-1-phosphate (S1P) in the lung of unchallenged Cftr tm1EUR F508del CFTR mutant mice. This cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd551ea544b6bc097ec39e4f6debe904
https://hdl.handle.net/1887/112828
https://hdl.handle.net/1887/112828
Autor:
Bob J. Scholte, Gimano D. Amatngalim, Marta Stolarczyk, Mieke Veltman, Pieter S. Hiemstra, Xiao Yu
Publikováno v:
Physiological Reports, 4(16)
Physiological Reports
Physiological Reports, 4(16). Wiley Open Access
Physiological Reports, 4(16). John Wiley & Sons Inc.
Physiological Reports
Physiological Reports, 4(16). Wiley Open Access
Physiological Reports, 4(16). John Wiley & Sons Inc.
Aberrant activity of a disintegrin and metalloprotease 17 (ADAM17), also known as TACE, and epidermal growth factor receptor (EGFR) has been suggested to contribute to chronic obstructive pulmonary disease (COPD) development and progression. The aim