Lipopolysaccharide‐induced hypothalamic inflammation in cancer cachexia‐anorexia is amplified by tumour‐derived prostaglandin E2

Autor: Xiaolin Li, Tosca Holtrop, Fleur A.C. Jansen, Brennan Olson, Pete Levasseur, Xinxia Zhu, Mieke Poland, Winni Schalwijk, Renger F. Witkamp, Daniel L. Marks, Klaske vanNorren

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 6, Pp 3014-3027 (2022)

Abstract Background Cachexia‐anorexia syndrome is a complex metabolic condition characterized by skeletal muscle wasting, reduced food intake and prominent involvement of systemic and central inflammation. Here, the gut barrier function was investi

Externí odkaz: https://doaj.org/article/29f9d48912b94de994b5625095893167

A Diet Rich in Fish Oil and Leucine Ameliorates Hypercalcemia in Tumour-Induced Cachectic Mice

Autor: Rogier L.C. Plas, Mieke Poland, Joyce Faber, Josep Argilès, Miriam van Dijk, Alessandro Laviano, Jocelijn Meijerink, Renger F. Witkamp, Ardy van Helvoort, Klaske van Norren

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 20, p 4978 (2019)

Background: Dietary supplementation with leucine and fish oil rich in omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has previously been shown to reduce cachexia-related outcomes in C26 tumour-bearing mice. To further

Externí odkaz: https://doaj.org/article/b24368c0832e482fb7b3a9c10d1303ed

PUFA-Derived N-Acylethanolamide Probes Identify Peroxiredoxins and Small GTPases as Molecular Targets in LPS-Stimulated RAW264.7 Macrophages

Autor: Ian-Arris de Bus, Antoine H. P. America, Norbert C. A. de Ruijter, Milena Lam, Jasper W. van de Sande, Mieke Poland, Renger F. Witkamp, Han Zuilhof, Michiel G. J. Balvers, Bauke Albada

Publikováno v: Acs Chemical Biology, 17(8), 2054-2064
Acs Chemical Biology 17 (2022) 8

We studied the mechanistic and biological origins of anti-inflammatory poly-unsaturated fatty acid-derived N-acylethanolamines using synthetic bifunctional chemical probes of docosahexaenoyl ethanolamide (DHEA) and arachidonoyl ethanolamide (AEA) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c0781f01742234fa23d54a181005dd
https://research.wur.nl/en/publications/pufa-derived-n-acylethanolamide-probes-identify-peroxiredoxins-an

A diet rich in fish oil and Leucine Ameliorates Hypercalcemia in tumour-induced cachectic mice

Autor: Alessandro Laviano, Joyce Faber, Ardy van Helvoort, Renger F. Witkamp, Jocelijn Meijerink, Josep M. Argilés, Mieke Poland, Miriam van Dijk, Klaske van Norren, Rogier L. C. Plas

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 20
International Journal of Molecular Sciences, Vol 20, Iss 20, p 4978 (2019)
International Journal of Molecular Sciences, 20(20)
International journal of molecular sciences, 20(20):4978. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences 20 (2019) 20
Dipòsit Digital de la UB
Universidad de Barcelona

Background: Dietary supplementation with leucine and fish oil rich in omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has previously been shown to reduce cachexia-related outcomes in C26 tumour-bearing mice. To further

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea03ff88e3be8d57c80cd9f0fc5072e7
http://hdl.handle.net/2445/158541

Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoidN-docosahexaenoylethanolamine (DHEA) in macrophages

Autor: Jvalini Dwarkasing, Renger F. Witkamp, Pierluigi Plastina, Klaske van Norren, Jocelijn Meijerink, Michiel G.J. Balvers, Mieke Poland, Carolien Lute

Publikováno v: British Journal of Pharmacology. 172:24-37

Background and Purpose N-docosahexaenoylethanolamine (DHEA) is the ethanolamine conjugate of the long-chain polyunsaturated n-3 fatty acid docosahexaenoic (DHA; 22: 6n-3). Its concentration in animal tissues and human plasma increases when diets rich

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16b04021298c8984bd422c95b33002b7
https://doi.org/10.1111/bph.12747