Light-Driven Enzymatic Decarboxylation of Fatty Acids

Autor: Fabio Tonin, Wuyuan Zhang, Frank Hollmann, Mieke M.E. Huijbers

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Edition), 57(41)

The photoenzymatic decarboxylation of fatty acids to alkanes is proposed as an alternative approach for the synthesis of biodiesel. By using a recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) we demonstrate the irreversi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9178b502629651327efabb7cf704635
https://doi.org/10.1002/anie.201807119

Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids

Autor: Wilson A. Smith, Ming Ma, Mieke M.E. Huijbers, Sabrina R. de Boer, Morten M. C. H. van Schie, Wuyuan Zhang, Bastien O. Burek, Willem J. H. van Berkel, Evgeny A. Pidko, Frank Hollmann, Georgy A. Filonenko, Jonathan Z. Bloh

Publikováno v: Journal of the American Chemical Society, 141(7)
Journal of the American Chemical Society, 141(7), 3116-3120
Journal of the American Chemical Society 141 (2019) 7
Journal of the American Chemical Society

A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3349044c78ed73f1dc0f87db6f1c64
http://resolver.tudelft.nl/uuid:f94eb29d-8fdb-46d3-a040-6ff2445524e6

The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN inTalaromyces islandicus(‘Penicillium islandicum’)

Autor: Philippe Jacques, Jutta Ludwig-Müller, David P. Fewer, Jouni Jokela, Tilmann Weber, Kaarina Sivonen, Norbert Kirchner, Thibault Caradec, Harald Gross, Mieke M.E. Huijbers, Thomas Schafhauser, Valérie Leclère, Linda Jahn, Willem J. H. van Berkel, Andreas Kulik, Wolfgang Wohlleben, Karl-Heinz van Pée, Liane Flor

Publikováno v: Environmental Microbiology. 18:3728-3741

Talaromyces islandicus ('Penicillium islandicum') is a widespread foodborne mold that produces numerous secondary metabolites, among them potent mycotoxins belonging to different chemical classes. A notable metabolite is the hepatotoxic and carcinoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86cf78f15174157c9c8d7f79f55b95c4
https://doi.org/10.1111/1462-2920.13294

Photochemical regeneration of flavoenzymes – An Old Yellow Enzyme case-study

Autor: Caroline E. Paul, Martin Pabst, Frank Hollmann, Milja Pesic, Isabel W. C. E. Arends, Mieke M.E. Huijbers, Marine Rauch

Publikováno v: Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics
BBA-Proteins and Proteomics, 1868(1)

Direct, NAD(P)H-independent regeneration of Old Yellow Enzymes represents an interesting approach for simplified reaction schemes for the stereoselective reduction of conjugated C=C-double bonds. Simply by illuminating the reaction mixtures with blue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25389832cd6fb321a20f9ea93c7821c9
https://doi.org/10.1016/j.bbapap.2019.140303

Flavin dependent monooxygenases

Autor: Mieke M.E. Huijbers, Willem J. H. van Berkel, Adrie H. Westphal, S. Montersino, Dirk Tischler

Publikováno v: Archives of Biochemistry and Biophysics, 544, 2-17
Archives of Biochemistry and Biophysics 544 (2014)

Flavin-dependent monooxygenases catalyze a wide variety of chemo-, regio- and enantioselective oxygenation reactions. As such, they are involved in key biological processes ranging from catabolism, detoxification and biosynthesis, to light emission a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12712106424fd7d4514c4fd6c293f0de
https://doi.org/10.1016/j.abb.2013.12.005