Výsledky vyhledávání - "Mieke F.A. Karel"

Akademický článek

Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function

Autor: Bibian M.E. Tullemans, Mieke F.A. Karel, Valentine Léopold, Marieke S. ten Brink, Constance C.F.M.J. Baaten, Sanne L. Maas, Alex F. deVos, Johannes A. Eble, Marten R. Nijziel, Emiel P.C. van derVorst, Judith M.E.M. Cosemans, Johan W.M. Heemskerk, Theodora A.M. Claushuis, Marijke J.E. Kuijpers

Publikováno v: eJHaem, Vol 2, Iss 4, Pp 685-699 (2021)

Abstract All irreversible Bruton tyrosine kinase (Btk) inhibitors including ibrutinib and acalabrutinib induce platelet dysfunction and increased bleeding risk. New reversible Btk inhibitors were developed, like MK‐1026. The mechanism underlying in

Externí odkaz: https://doaj.org/article/44007a92296c4e6e8eb464bf7bca834a

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Complementary roles of platelet αIIbβ3 integrin, phosphatidylserine exposure and cytoskeletal rearrangement in the release of extracellular vesicles

Autor: Johan W. M. Heemskerk, Rory R. Koenen, Alexandra C.A. Heinzmann, Tanja Vajen, Tilman M. Hackeng, Daniëlle Coenen, Judith M.E.M. Cosemans, Mieke F.A. Karel, Dennis Suylen, Nicole Meulendijks, Magdolna Nagy

Publikováno v: Atherosclerosis, 310, 17-25. Elsevier Ireland Ltd

Background and aims: Platelets can release extracellular vesicles (EVs) upon stimulation with various agonists. Interestingly, platelets from patients with Glanzmann thrombasthenia have reduced EV release. These platelets lack functional alpha(IIb)be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78d20943879dc28ab40d7aaf65bf623
https://doi.org/10.1016/j.atherosclerosis.2020.07.015

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Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function

Autor: Theodora A. M. Claushuis, Marten R. Nijziel, Johannes A. Eble, Alex F. de Vos, Valentine Leopold, Emiel P. C. van der Vorst, Johan W. M. Heemskerk, Mieke F.A. Karel, Sanne L. Maas, Marijke J.E. Kuijpers, Constance C.F.M.J. Baaten, Marieke S. ten Brink, Judith M.E.M. Cosemans, Bibian M. E. Tullemans

Publikováno v: eJHaem, 2(4). John Wiley & Sons Inc.

All irreversible Bruton tyrosine kinase (Btk) inhibitors including ibrutinib and acalabrutinib induce platelet dysfunction and increased bleeding risk. New reversible Btk inhibitors were developed, like MK-1026. The mechanism underlying increased ble

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fcb2c34005362ca6018cab14c7b3a1
https://pubmed.ncbi.nlm.nih.gov/35845214

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Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery

Autor: W. Chayoua, Tom G. Mastenbroek, Judith M.E.M. Cosemans, Daniëlle Coenen, Magdolna Nagy, Marijke J.E. Kuijpers, Joke Konings, Peter Leenders, Stefan Heitmeier, A. E. Brouns, R. van Oerle, Henri M. H. Spronk, H. van Essen, E. I. J. Korsten, Jacques Debets, Mieke F.A. Karel

Publikováno v: Scientific Reports, 10(1):19360. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports

While in recent trials the dual pathway inhibition with aspirin plus rivaroxaban has shown to be efficacious in patients with atherosclerotic cardiovascular disease, little is known about the effects of this combination treatment on thrombus formatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7de0527b960c4474c782e7e97535c1
https://doi.org/10.1038/s41598-020-76377-8

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The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events

Autor: Daniëlle Coenen, Judith M.E.M. Cosemans, Alexandra C.A. Heinzmann, Rory R. Koenen, Mieke F.A. Karel

Publikováno v: Atherosclerosis. 319

Atherosclerosis is an underlying cause of a broad array of cardiovascular diseases characterized by plaques, arterial wall thickening initiated by hyperlipidemia, pro-inflammatory signals, endothelial dysfunction and the influx of inflammatory cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed53869a488f648d48645c7944c6984
https://pubmed.ncbi.nlm.nih.gov/33468314

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SLC44A2 deficient mice have a reduced response in stenosis but not in hypercoagulability driven venous thrombosis

Autor: Daniëlle Coenen, Sophie Dólleman, Annemarie M. van Oeveren-Rietdijk, Bart J.M. van Vlijmen, Judith M.E.M. Cosemans, Gaia Zirka, Hetty C. de Boer, Julia Tilburg, Pierre Morange, Mieke F.A. Karel, Grace M. Thomas, Henri H. Versteeg, Chrissta X. Maracle

Publikováno v: Journal of Thrombosis and Haemostasis, 18(7), 1714-1727. Wiley
Journal of Thrombosis and Haemostasis, 18(7), 1714-1727. WILEY
Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, 2020, 18 (7), pp.1714-1727. ⟨10.1111/jth.14835⟩
Journal of Thrombosis and Haemostasis, Wiley, 2020, 18 (7), pp.1714-1727. ⟨10.1111/jth.14835⟩

Background Genome wide association studies (GWAS) identified SLC44A2 as a novel susceptibility gene for venous thrombosis (VT) and previous work established that SLC44A2 contributed to clot formation upon vascular injury.Objective To further investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b97e5fdd2cea895cabd20960869551
https://cris.maastrichtuniversity.nl/en/publications/65410a1a-458e-4e26-b74c-59a5714ec1f9

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