Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids

Autor: Lonneke H. Gaykema, Rianne Y. van Nieuwland, Mette C. Dekkers, Mieke F. van Essen, Sebastiaan Heidt, Arnaud Zaldumbide, Cathelijne W. van den Berg, Ton J. Rabelink, Cees van Kooten

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

End stage renal disease is an increasing problem worldwide driven by aging of the population and increased prevalence of metabolic disorders and cardiovascular disease. Currently, kidney transplantation is the only curative option, but donor organ sh

Externí odkaz: https://doaj.org/article/835be6d250e348cf9618b0962374af31

Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys

Autor: Mieke F van Essen, Jacob J.E. Koopman, Aiko P. J. de Vries, Helmut G. Rennke, Cees van Kooten

Publikováno v: Frontiers in Immunology, Vol 11 (2021)
Frontiers in Immunology, 11. FRONTIERS MEDIA SA
Frontiers in Immunology

The membrane attack complex—also known as C5b-9—is the end-product of the classical, lectin, and alternative complement pathways. It is thought to play an important role in the pathogenesis of various kidney diseases by causing cellular injury an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086ec9f731806f2e2eed0ceea2ed1729
https://www.frontiersin.org/articles/10.3389/fimmu.2020.599974/full

Local delivery of liposomal prednisolone leads to an anti-inflammatory profile in renal ischaemia-reperfusion injury in the rat

Autor: Mark Boonstra, Joris I. Rotmans, Alexander L. Vahrmeijer, Onno C. Meijer, Johan W. de Fijter, Marlies E.J. Reinders, Eric P. van der Veer, Taisiya Bezhaeva, Carla M. A. van Alem, Jurjen M. Ruben, Mieke F van Essen, Cees van Kooten, Josbert M. Metselaar, Jurriën Prins

Publikováno v: Nephrology Dialysis Transplantation
Nephrology Dialysis Transplantation, 33(1), 44-53. Oxford Academic
Nephrology Dialysis Transplantation, 33(1), 44-53

BACKGROUND:Treatment of inflammatory kidney diseases with systemic high-dose glucocorticoids (GCs) has severe side effects. Liposomal encapsulation could facilitate local delivery of GCs to the inflamed kidney, as liposomes encapsulate their payload

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60addcdff0b3453b23823d96eaf85b14
https://hdl.handle.net/1887/95463

Comprehensive analysis of neuronal guidance cue expression regulation during monocyte-to-macrophage differentiation reveals post-transcriptional regulation of semaphorin7A by the RNA-binding protein quaking

Autor: Huayu Zhang, Jurriën Prins, Dianne Vreeken, Barend W Florijn, Ruben G de Bruin, Oscar RJ van Hengel, Mieke F van Essen, Jacques MGJ Duijs, Hilde Van Esch, Eric P van der Veer, Anton Jan van Zonneveld, Janine M van Gils

Publikováno v: Innate Immunity, Vol 27 (2021)

In response to inflammatory cytokines and chemokines, monocytes differentiate into macrophages. Comprehensive analysis of gene expression regulation of neuronal guidance cue (NGC) ligands and receptors in the monocyte-to-macrophage differentiation pr

Externí odkaz: https://doaj.org/article/cbb8dffc31294d6993f3522eca85b8a1