Výsledky vyhledávání - "Mieke C Brouwer"

Akademický článek

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation

Autor: Esther CW deBoer, Astrid JF Thielen, Jeroen D Langereis, Angela Kamp, Mieke C Brouwer, Nienke Oskam, Marlieke L Jongsma, April J Baral, Robbert M Spaapen, Sacha Zeerleder, Gestur Vidarsson, Theo Rispens, Diana Wouters, Richard B Pouw, Ilse Jongerius

Publikováno v: Clinical & Translational Immunology, Vol 12, Iss 1, Pp n/a-n/a (2023)

Abstract Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation. However, the role of the AP in classi

Externí odkaz: https://doaj.org/article/f6250e5b1dc740bdaebae56b5cf8eb40

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Akademický článek

Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3.

Autor: Richard B Pouw, Mieke C Brouwer, Judy Geissler, Laurens V van Herpen, Sacha S Zeerleder, Walter A Wuillemin, Diana Wouters, Taco W Kuijpers

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0152164 (2016)

The major human complement regulator in blood, complement factor H (FH), has several closely related proteins, called FH-related (FHR) proteins. As all FHRs lack relevant complement regulatory activity, their physiological role is not well understood

Externí odkaz: https://doaj.org/article/6b77dc779c5f431aab702068798d9cf8

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Akademický článek

Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4

Autor: Richard B. Pouw, Mieke C. Brouwer, Anna E. van Beek, Mihály Józsi, Diana Wouters, Taco W. Kuijpers

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are hypothesized to act as antagonists of the important complement regulator factor H (FH), fine-tuning complement regulation on h

Externí odkaz: https://doaj.org/article/766b4f5dac5846798d91a18943a4fcb9

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Mechanisms driving neutrophil-induced t-cell immunoparalysis in ovarian cancer

Publikováno v: Cancer immunology research, 9(7), 790-810. American Association for Cancer Research Inc.

T-cell activation and expansion in the tumor microenvironment (TME) are critical for antitumor immunity. Neutrophils in the TME acquire a complement-dependent T-cell suppressor phenotype that is characterized by inhibition of T-cell proliferation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec2b3e407c4193b0f84c9e678f3bd26
http://www.scopus.com/inward/record.url?scp=85109040656&partnerID=8YFLogxK

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Akademický článek

Autor: Anna E. van Beek, Richard B. Pouw, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Pleuni Ooijevaar-de Heer, Martin de Boer, Karin van Leeuwen, Theo Rispens, Diana Wouters, Taco W. Kuijpers

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

The complement factor H-related (FHR) proteins are hypothesized to fine-tune the regulatory role of complement factor H (FH) in the alternative pathway of the complement system. Moreover, FHR-1, FHR-2, and FHR-5 have been proposed to be dimers, which

Externí odkaz: https://doaj.org/article/fb471257e25b469cb0328c252b127083

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Impact of the COVID-19 outbreak on acute stroke care

Autor: Jonathan M. Coutinho, Jessica Burggraaff, Leon A. Rinkel, S. M. van Schaik, Mieke C. Brouwer, J. C. M. Prick, R. E. R. Slot, Marieke C. Visser, Charles B. L. M. Majoie, Bart J. Emmer, D. van de Beek, Adrien E. Groot, N. M. A. Sombroek, Yvo B.W.E.M. Roos, R M Van den Berg-Vos, Ludo F. M. Beenen

Publikováno v: Journal of neurology, 268(2), 403-408. D. Steinkopff-Verlag
Journal of Neurology

Background and purpose There are concerns that the coronavirus disease 2019 (COVID-19) outbreak negatively affects the quality of care for acute cardiovascular conditions. We assessed the impact of the COVID-19 outbreak on trends in hospital admissio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802c8af58933ccddb966c2dbfc3ac4ee
http://www.scopus.com/inward/record.url?scp=85088243905&partnerID=8YFLogxK

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Low Levels of Factor H Family Proteins During Meningococcal Disease Indicate Systemic Processes Rather Than Specific Depletion by Neisseria meningitidis

Autor: Anna E. van Beek, Richard B. Pouw, Victoria J. Wright, Neneh Sallah, David Inwald, Clive Hoggart, Mieke C. Brouwer, Rachel Galassini, John Thomas, Leo Calvo-Bado, Colin G. Fink, Ilse Jongerius, Martin Hibberd, Diana Wouters, Michael Levin, Taco W. Kuijpers

Publikováno v: Frontiers in immunology, 13:876776. Frontiers Media S.A.

Neisseria meningitidis, the causative agent of meningococcal disease (MD), evades complement-mediated clearance upon infection by ‘hijacking’ the human complement regulator factor H (FH). The FH protein family also comprises the homologous FH-rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cfc3c7b1ef870a60957e7cfc9d9f74

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