Zobrazeno 1 - 10 of 68 pro vyhledávání: '"Mieke A. Dentener"'
1
Akademický článek
Smoking-Associated Exposure of Human Primary Bronchial Epithelial Cells to Aldehydes: Impact on Molecular Mechanisms Controlling Mitochondrial Content and Function
Autor: Christy B. M. Tulen, Evert Duistermaat, Johannes W. J. M. Cremers, Walther N. M. Klerx, Paul H. B. Fokkens, Naömi Weibolt, Nico Kloosterboer, Mieke A. Dentener, Eric R. Gremmer, Phyllis J. J. Jessen, Evi J. C. Koene, Lou Maas, Antoon Opperhuizen, Frederik-Jan van Schooten, Yvonne C. M. Staal, Alexander H. V. Remels
Publikováno v: Cells, Vol 11, Iss 21, p 3481 (2022)
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease primarily caused by exposure to cigarette smoke (CS). During the pyrolysis and combustion of tobacco, reactive aldehydes such as acetaldehyde, acrolein, and formaldehyde are f
Externí odkaz: https://doaj.org/article/2858f0d527984676b53f121e83d3e3b9
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2
Akademický článek
Efficacy of IFN-λ1 to protect human airway epithelial cells against human rhinovirus 1B infection.
Autor: Fahad Gulraiz, Carla Bellinghausen, Mieke A Dentener, Niki L Reynaert, Giel R Gaajetaan, Erik V Beuken, Gernot G Rohde, Cathrien A Bruggeman, Frank R Stassen
Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95134 (2014)
Impaired interferon (IFN) production has been observed in various obstructive respiratory diseases. This contributes to enhanced sensitivity towards viral infections triggering acute exacerbations. To compensate for this impaired host IFN response, t
Externí odkaz: https://doaj.org/article/9cffa8c9512d4d4d87f29035bd381ddb
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3
Akademický článek
Cigarette smoke extract induces a phenotypic shift in epithelial cells; involvement of HIF1α in mesenchymal transition.
Autor: Irene M J Eurlings, Niki L Reynaert, Twan van den Beucken, Harry R Gosker, C C de Theije, Fien M Verhamme, Ken R Bracke, Emiel F M Wouters, Mieke A Dentener
Publikováno v: PLoS ONE, Vol 9, Iss 10, p e107757 (2014)
In COPD, matrix remodeling contributes to airflow limitation. Recent evidence suggests that next to fibroblasts, the process of epithelial-mesenchymal transition can contribute to matrix remodeling. CSE has been shown to induce EMT in lung epithelial
Externí odkaz: https://doaj.org/article/2a1f242076c345389bba66b876aae1e5
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5
Involvement of c-Jun N-Terminal Kinase in TNF-alpha-Driven Remodeling
Autor: Cheryl van de Wetering, Yvonne M. W. Janssen-Heininger, Emiel F.M. Wouters, Jos van der Velden, Evi M. Mercken, Scott W. Aesif, Rafael de Cabo, Niki L. Reynaert, Irene M. J. Eurlings, Mieke A. Dentener
Publikováno v: American Journal of Respiratory Cell and Molecular Biology, 56(3), 393-401. American Thoracic Society
Lung tissue remodeling in chronic obstructive pulmonary disease (COPD) is characterized by airway wall thickening and/or emphysema. Although the bronchial and alveolar compartments are functionally independent entities, we recently showed comparable
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67defa38a7e3b5756346687bfba2e974
https://cris.maastrichtuniversity.nl/en/publications/6780f687-28ee-4bc9-9b0c-c52b0f477d8c
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6
Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells
Autor: Gernot Rohde, Niki L. Reynaert, Timothy N. Perkins, Frank R. M. Stassen, Emiel F.M. Wouters, Mieke A. Dentener, Brooke T. Mossman
Publikováno v: Toxicology and Applied Pharmacology, 301, 61-70. Elsevier Science
Growth and development of the mature lung is a complex process orchestrated by a number of intricate developmental signaling pathways. Wingless-type MMTV-integration site (WNT) signaling plays critical roles in controlling branching morphogenesis cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3d27868f3f996a81eb2b06e5aa4dce
https://doi.org/10.1016/j.taap.2016.04.003
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7
Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells
Autor: Emiel F.M. Wouters, Catrin Albrecht, Timothy N. Perkins, Niki L. Reynaert, Mieke A. Dentener, Brooke T. Mossman, Paul Peeters, Roel P. F. Schins
Publikováno v: Toxicology and Applied Pharmacology, 348, 43-53. Elsevier Science
Lung epithelial cells are the first cell-type to come in contact with hazardous dust materials. Upon deposition, they invoke complex reactions in attempt to eradicate particles from the airways, and repair damage. The cell surface is composed of a he
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b745d38a8825861278d233c6135e4ab0
https://cris.maastrichtuniversity.nl/en/publications/681a305d-51e3-49ae-8260-1313eb2f3ec5
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8
A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α
Autor: Niki L. Reynaert, Juanita H. J. Vernooy, Mieke A. Dentener, Emiel F.M. Wouters, Evi M. Mercken, Ken R. Bracke, Irene M. J. Eurlings, Rafael de Cabo
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology, 307(7), L557-L565. American Physiological Society
Remodeling in chronic obstructive pulmonary disease (COPD) has at least two dimensions: small airway wall thickening and destruction of alveolar walls. Recently we showed comparable alterations of the extracellular matrix (ECM) compounds collagen, hy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2106d9e4e10c8b0e9d15efd3912420c3
https://cris.maastrichtuniversity.nl/en/publications/c6f6c14e-ddde-4e0d-9126-71f71614b245
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9
Interferon-beta induces a long-lasting antiviral state in human respiratory epithelial cells
Autor: Giel R. Gaajetaan, Gernot Rohde, Frank R. M. Stassen, Cathrien A. Bruggeman, Niki L. Reynaert, Juanita H. J. Vernooy, Erik V. Beuken, Gert Grauls, Mieke A. Dentener, Tanja H. Geelen
Publikováno v: Journal of Infection, 66(2), 163-169. Elsevier Saunders
OBJECTIVES: Interferon-beta (IFNbeta) induces strong antiviral effects and is therefore an attractive agent to prevent or reduce the incidence of virus-mediated exacerbations in asthmatic or chronic obstructive pulmonary disease (COPD) patients. We t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f28788b381e24dd23e07d775f0fb85
https://doi.org/10.1016/j.jinf.2012.11.008
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10
Exposure to common respiratory bacteria alters the airway epithelial response to subsequent viral infection
Autor: Paul H. M. Savelkoul, Gernot Rohde, Mieke A. Dentener, Carla Bellinghausen, Alexandra C.A. Heinzmann, Frank R. M. Stassen, Emiel F.M. Wouters, Fahad Gulraiz
Publikováno v: Bellinghausen, C, Gulraiz, F, Heinzmann, A C A, Dentener, M A, Savelkoul, P H M, Wouters, E F M, Rohde, G G U & Stassen, F R M 2016, ' Exposure to common respiratory bacteria alters the airway epithelial response to subsequent viral infection ', Respiration Research, vol. 17, no. 1, pp. 68 . https://doi.org/10.1186/s12931-016-0382-z
Respiratory Research, 17:68. BioMed Central Ltd
Respiratory Research
Respiration Research, 17(1)
Background Colonization of the airways with potential pathogenic bacteria is observed in a number of chronic respiratory diseases, such as COPD or cystic fibrosis. Infections with respiratory viruses are known triggers of exacerbations of these disea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36626a9ff59a38e3a91f8f3a196b776a
https://research.vumc.nl/en/publications/51f3f3a0-cc25-40df-b6ee-b5dd3de120e7
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