Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Miek M. Moons"'
Autor:
Richard Engbersen, Paul Smits, H.B.P.M. Dijkman, Cees Kramers, Frans G. M. Russel, Alfons C. Wouterse, Miek M. Moons
Publikováno v:
British Journal of Pharmacology. 130:1678-1684
Sulphonylurea drugs have been shown to protect against hypoxic damage in isolated proximal tubules of the kidney. In the present study we investigated whether these drugs can protect against hypoxic damage in a whole kidney preparation. Tolbutamide (
Publikováno v:
Journal of Pharmacy and Pharmacology, 48, 560-565
Journal of Pharmacy and Pharmacology, 48, 6, pp. 560-565
ResearcherID
Journal of Pharmacy and Pharmacology, 48, pp. 560-565
Journal of Pharmacy and Pharmacology, 48, 6, pp. 560-565
ResearcherID
Journal of Pharmacy and Pharmacology, 48, pp. 560-565
The effect of protein binding on kidney function has been studied by investigating the renal accumulation and secretion of the hippurate analogue 2-methylbenzoylglycine in the isolated perfused rat kidney in the absence and presence of bovine serum a
Autor:
Helene L.M. Siero, Richard Engbersen, Paul Smits, Miek M. Moons, Rosalinde Masereeuw, Frans G. M. Russel, Miriam A. van Gestel
Publikováno v:
European Journal of Pharmacology, 681, 1-3, pp. 75-9
European Journal of Pharmacology, 681, 75-9
European Journal of Pharmacology, 681, 75-9
Contains fulltext : 110913.pdf (Publisher’s version ) (Closed access) Sulfonylurea drugs exert their insulinotropic action by inhibiting ATP-sensitive potassium channels in the pancreas. However, these channels are also expressed in myocardial and
Publikováno v:
Pharmacology. 42:287-296
We investigated renal handling and effects of indometacin on renal function in the isolated perfused rat kidney (IPK). Indometacin concentrations less than 2.5 ng/ml did not influence renal function, while higher concentrations caused a decrease in u
Publikováno v:
Journal of Pharmacological Methods. 24:89-103
An isolated perfused rat kidney (IPK) preparation is described in which renal perfusion flow, perfusion pressure, urinary flow, urinary pH, and glomerular filtration rate (GFR) are recorded continuously during the perfusion experiment. The usefulness
Publikováno v:
Journal of Pharmacy and Pharmacology, 50, pp. 1397-1404
ResearcherID
Journal of Pharmacy and Pharmacology, 50, 1397-1404
Scopus-Elsevier
ResearcherID
Journal of Pharmacy and Pharmacology, 50, 1397-1404
Scopus-Elsevier
Hippurates tend to accumulate within proximal tubule cells during renal secretion. High intracellular concentrations can alter proximal tubular function or lead to tubular toxicity. In this study we examined the renal disposition of the hippurate 4-m
Publikováno v:
Toxicology Letters. 53:175-177
Publikováno v:
European Journal of Pharmacology, 321, 3, pp. 315-323
European Journal of Pharmacology, 321, 315-323
European Journal of Pharmacology, 321, 315-323-323
European Journal of Pharmacology, 321, pp. 315-323-323
European Journal of Pharmacology, 321, 315-323
European Journal of Pharmacology, 321, 315-323-323
European Journal of Pharmacology, 321, pp. 315-323-323
Rhodamine 123 has been shown to be a substrate for P-glycoprotein in multidrug resistant cells. In the present investigation the disposition of rhodamine 123 was studied in the isolated perfused rat kidney. After exposing the kidneys to perfusate con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34729d0778c9a4a395f71e159e1f6f62
https://doi.org/10.1016/S0014-2999(96)00957-0
https://doi.org/10.1016/S0014-2999(96)00957-0
Publikováno v:
European Journal of Pharmaceutical Sciences, 5, 295-301
European Journal of Pharmaceutical Sciences, 5, pp. 295-301
European Journal of Pharmaceutical Sciences, 5, pp. 295-301
The present study was designed to investigate the renal disposition of diatrizoate in the isolated perfused rat kidney (IPK). To the IPK, 5 different doses were added (between 1.13 and 44 mg), resulting in initial perfusate concentrations between 4.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a7695937e88b9e2c9f412d7cbd2cb4
http://hdl.handle.net/2066/256967
http://hdl.handle.net/2066/256967
Publikováno v:
British Journal of Pharmacology, 119, pp. 57-64
British Journal of Pharmacology, 119, 57-64
British Journal of Pharmacology, 119, 1, pp. 57-64
ResearcherID
British Journal of Pharmacology, 119, 57-64
British Journal of Pharmacology, 119, 1, pp. 57-64
ResearcherID
1. The renal handling of iohexol was examined in the rat isolated perfused kidney (IPK) over a perfusate concentration range of 5-20 micrograms ml-1. 2. At a concentration of 5 micrograms ml-1, a ratio of renal clearance over clearance by glomerular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bda578635482cfd1e90027d0057797e
https://repository.ubn.ru.nl/handle/2066/264698
https://repository.ubn.ru.nl/handle/2066/264698