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A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.

Autor: Aleman J; University of Pittsburgh Drug Discovery Institute, Pittsburgh, USA.; University of Pittsburgh Department of Bioengineering, Pittsburgh, USA., K R; University of Pittsburgh Department of Chemical and Petroleum Engineering, Pittsburgh, USA., Wiegand C; University of Pittsburgh Department of Chemical and Petroleum Engineering, Pittsburgh, USA., Schurdak ME; University of Pittsburgh Drug Discovery Institute, Pittsburgh, USA.; University of Pittsburgh Department of Computational and Systems Biology, Pittsburgh, USA.; University of Pittsburgh Liver Research Center, Pittsburgh, USA., Vernetti L; University of Pittsburgh Drug Discovery Institute, Pittsburgh, USA.; University of Pittsburgh Department of Computational and Systems Biology, Pittsburgh, USA.; University of Pittsburgh Liver Research Center, Pittsburgh, USA., Gavlock D; University of Pittsburgh Drug Discovery Institute, Pittsburgh, USA., Reese C; University of Pittsburgh Drug Discovery Institute, Pittsburgh, USA., DeBiasio R; University of Pittsburgh Drug Discovery Institute, Pittsburgh, USA., LaRocca G; University of Pittsburgh Drug Discovery Institute, Pittsburgh, USA., Angarita YD; University of Pittsburgh Department of Bioengineering, Pittsburgh, USA., Gough A; University of Pittsburgh Drug Discovery Institute, Pittsburgh, USA.; University of Pittsburgh Department of Computational and Systems Biology, Pittsburgh, USA., Soto-Gutierrez A; University of Pittsburgh Liver Research Center, Pittsburgh, USA.; University of Pittsburgh Department of Pathology, Pittsburgh, USA., Behari J; Division of Gastroenterology, Hepatology and Nutrition, School of Medicine, University of Pittsburgh, Pittsburgh, USA., Yechoor VK; Diabetes and Beta Cell Biology Center, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, USA., Miedel MT; University of Pittsburgh Drug Discovery Institute, Pittsburgh, USA.; University of Pittsburgh Liver Research Center, Pittsburgh, USA.; University of Pittsburgh Department of Pathology, Pittsburgh, USA., Stern AM; University of Pittsburgh Drug Discovery Institute, Pittsburgh, USA. sternam@pitt.edu.; University of Pittsburgh Department of Computational and Systems Biology, Pittsburgh, USA. sternam@pitt.edu., Banerjee I; University of Pittsburgh Department of Bioengineering, Pittsburgh, USA. ipb1@pitt.edu.; University of Pittsburgh Department of Chemical and Petroleum Engineering, Pittsburgh, USA. ipb1@pitt.edu., Taylor DL; University of Pittsburgh Drug Discovery Institute, Pittsburgh, USA. dltaylor@pitt.edu.; University of Pittsburgh Department of Bioengineering, Pittsburgh, USA. dltaylor@pitt.edu.; University of Pittsburgh Department of Computational and Systems Biology, Pittsburgh, USA. dltaylor@pitt.edu.; University of Pittsburgh Liver Research Center, Pittsburgh, USA. dltaylor@pitt.edu.

Publikováno v: Communications biology [Commun Biol] 2024 Oct 14; Vol. 7 (1), pp. 1317. Date of Electronic Publication: 2024 Oct 14.

Human induced pluripotent stem cell based hepatic-modeling of lipid metabolism associated TM6SF2 E167K variant.

Autor: Faccioli LA; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Sun Y; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; School of Medicine, Tsinghua University, Beijing, PRC., Animasahun O; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI., Motomura T; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Liu Z; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Kurihara T; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Hu Z; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Yang B; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Cetin Z; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Baratta AM; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Shankaran A; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI., Nenwani M; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Altay LN; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI., Huang L; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI., Meurs N; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Franks J; Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA., Stolz D; Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA., Gavlock DC; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, USA., Miedel MT; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, USA., Ostrowska A; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Florentino RM; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Fox IJ; Department of Surgery, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA., Nagrath D; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Soto-Gutierrez A; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2024 Aug 27. Date of Electronic Publication: 2024 Aug 27.

Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system.

Autor: Negi V; Diabetes and Beta Cell Biology Center, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, USA. yechoorv@pitt.edu., Gavlock D; Drug Discovery Institute and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA., Miedel MT; Drug Discovery Institute and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA., Lee JK; Diabetes and Beta Cell Biology Center, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, USA. yechoorv@pitt.edu., Shun T; Drug Discovery Institute and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA., Gough A; Drug Discovery Institute and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA., Vernetti L; Drug Discovery Institute and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA., Stern AM; Drug Discovery Institute and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA., Taylor DL; Drug Discovery Institute and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA., Yechoor VK; Diabetes and Beta Cell Biology Center, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, USA. yechoorv@pitt.edu.

Publikováno v: Lab on a chip [Lab Chip] 2023 Oct 10; Vol. 23 (20), pp. 4514-4527. Date of Electronic Publication: 2023 Oct 10.

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.

Autor: Beaudoin JJ; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Clemens L; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Miedel MT; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA., Gough A; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA., Zaidi F; Metabolon Inc., Durham, NC 27713, USA., Ramamoorthy P; Metabolon Inc., Durham, NC 27713, USA., Wong KE; Metabolon Inc., Durham, NC 27713, USA., Sarangarajan R; Metabolon Inc., Durham, NC 27713, USA., Battista C; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Shoda LKM; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Siler SQ; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Taylor DL; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA., Howell BA; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Vernetti LA; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA., Yang K; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 02; Vol. 24 (11). Date of Electronic Publication: 2023 Jun 02.