Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mie Yoshimatsu"'
Autor:
Sei Yoshida, Tomoyasu Ishikawa, Ryuichi Tozawa, Hideki Yamasaki, Mie Yoshimatsu, Shunsuke Yamamoto, Kazunobu Aoyama, Yohei Kosugi, Kentaro Hashimoto, Masakazu Inazuka, Ryosuke Hibino, Megumi Morimoto, Kenichi Iwai, Masato Yabuki, Hiroyuki Sumi
PDF file - 57KB, Growth inhibition potency of T-3256336 on several cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64856fd68f91e12c9bd1c4668cc2d259
https://doi.org/10.1158/1535-7163.22499001.v1
https://doi.org/10.1158/1535-7163.22499001.v1
Autor:
Sei Yoshida, Tomoyasu Ishikawa, Ryuichi Tozawa, Hideki Yamasaki, Mie Yoshimatsu, Shunsuke Yamamoto, Kazunobu Aoyama, Yohei Kosugi, Kentaro Hashimoto, Masakazu Inazuka, Ryosuke Hibino, Megumi Morimoto, Kenichi Iwai, Masato Yabuki, Hiroyuki Sumi
PDF file - 55KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e86321c01256324a3561583091c2695
https://doi.org/10.1158/1535-7163.22498983
https://doi.org/10.1158/1535-7163.22498983
Autor:
Sei Yoshida, Tomoyasu Ishikawa, Ryuichi Tozawa, Hideki Yamasaki, Mie Yoshimatsu, Shunsuke Yamamoto, Kazunobu Aoyama, Yohei Kosugi, Kentaro Hashimoto, Masakazu Inazuka, Ryosuke Hibino, Megumi Morimoto, Kenichi Iwai, Masato Yabuki, Hiroyuki Sumi
PDF file - 37KB, Pharmacokinetic parameters of T-3256336 in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5742e34fb55d3f121519c8c1dbf38ca1
https://doi.org/10.1158/1535-7163.22498980
https://doi.org/10.1158/1535-7163.22498980
Autor:
Sei Yoshida, Tomoyasu Ishikawa, Ryuichi Tozawa, Hideki Yamasaki, Mie Yoshimatsu, Shunsuke Yamamoto, Kazunobu Aoyama, Yohei Kosugi, Kentaro Hashimoto, Masakazu Inazuka, Ryosuke Hibino, Megumi Morimoto, Kenichi Iwai, Masato Yabuki, Hiroyuki Sumi
PDF file - 72KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f86e645811a24fa2a58e54d3565b47c
https://doi.org/10.1158/1535-7163.22499013
https://doi.org/10.1158/1535-7163.22499013
Autor:
Tomoyasu Ishikawa, Masato Yabuki, Sei Yoshida, Nao Morishita, Teruki Hamada, Kentaro Hashimoto, Clifford D. Mol, Douglas R. Dougan, Kazunobu Aoyama, Zenyu Shiokawa, Hiroyuki Sumi, Moriteru Asano, Mie Yoshimatsu, Bunnai Saito
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:5725-5737
We recently reported the discovery of octahydropyrrolo[1,2-a]pyrazine A as a lead compound for an inhibitor of apoptosis proteins (IAP) antagonist. To develop IAP antagonists with favorable PK profiles, we designed novel tri-cyclic compounds, octahyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aaf7eac41ce20577a038d7a5215f402
https://doi.org/10.1016/j.bmc.2013.07.020
https://doi.org/10.1016/j.bmc.2013.07.020
Autor:
Ryosuke Hibino, Masakazu Inazuka, Megumi Morimoto, Tomoyasu Ishikawa, Mie Yoshimatsu, Ryuichi Tozawa, Masato Yabuki, Kenichi Iwai, Hiroyuki Sumi, Kazunobu Aoyama, Hideki Yamasaki, Yohei Kosugi, Shunsuke Yamamoto, Sei Yoshida, Kentaro Hashimoto
Publikováno v:
Molecular Cancer Therapeutics. 12:230-240
Inhibitor of apoptosis proteins (IAP), which are key regulators of apoptosis, are inhibited by second mitochondria-derived activator of caspase (SMAC). Small-molecule IAP antagonists have recently been reported as novel therapeutic treatments for can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7178b8d23ef94fdae7578b054f8bb6de
https://doi.org/10.1158/1535-7163.mct-12-0699
https://doi.org/10.1158/1535-7163.mct-12-0699
Autor:
Satoshi Sogabe, Yusuke Kamada, Kotaro Sakamoto, Mie Yoshimatsu, Kou Ida, Kouhei Asano, Junichi Sakamoto, Yasuhiro Imaeda, Nozomu Sakai
Publikováno v:
Biochemical and biophysical research communications. 482(2)
B cell lymphoma 6 (BCL6) is a transcriptional repressor that interacts with its corepressors BcoR and SMRT. Since this protein-protein interaction (PPI) induces activation and differentiation of B lymphocytes, BCL6 has been an attractive drug target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e549acdb82406af00cbd194b1936f0ce
https://pubmed.ncbi.nlm.nih.gov/27856253
https://pubmed.ncbi.nlm.nih.gov/27856253
Autor:
Daisuke Nakata, Satoshi Sasaki, Akira Tanaka, Mie Yoshimatsu, Kazumasa Hamamura, Shuichi Furuya, Kazuhiro Miwa, Tomoyuki Kitazaki, Takashi Imada, Takenori Hitaka, Satoshi Endo, Masami Kusaka
Publikováno v:
Journal of Medicinal Chemistry. 54:4998-5012
We previously discovered an orally active human gonadotropin-releasing hormone (GnRH) receptor antagonist, thieno[2,3-d]pyrimidine-2,4-dione derivative 1 (sufugolix). To reduce the cytochrome P450 (CYP) inhibitory activity and improve in vivo GnRH an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51fe5b89594e0e28250d6034b09d875
https://doi.org/10.1021/jm200216q
https://doi.org/10.1021/jm200216q
Autor:
Daisuke Nakata, Yumiko Akinaga, Kazuhiro Miwa, Reiko Sasada, Masami Kusaka, Tsuneo Masaki, Mari Asada, Michiyasu Takeyama, Mie Yoshimatsu, Akira Tanaka, Tatsuya Watanabe
Publikováno v:
European journal of pharmacology. 723
TAK-385 (relugolix) is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist, which builds on previous work with non-peptide GnRH antagonist TAK-013. TAK-385 possesses higher affinity and more potent antagonistic activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a7b28dc66a0e95d6877bc5162de3a2
https://pubmed.ncbi.nlm.nih.gov/24333551
https://pubmed.ncbi.nlm.nih.gov/24333551
Autor:
Gyorgy Snell, Mie Yoshimatsu, Hiroyuki Sumi, Yasuyuki Debori, Masato Yabuki, Tomoyasu Ishikawa, Nao Morishita, Bunnai Saito, Sei Yoshida, Zenyu Shiokawa, Yuya Oguro, Douglas R. Dougan, Kentaro Hashimoto, Yohei Kosugi
Publikováno v:
Bioorganicmedicinal chemistry. 21(24)
We previously reported octahydropyrrolo[1,2-a]pyrazine derivative 2 (T-3256336) as a potent antagonist for inhibitors of apoptosis (IAP) proteins. Because compound 2 was susceptible to MDR1 mediated efflux, we developed another scaffold, hexahydropyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaf9c1694ae0b9e921d4d76d03d7ea3
https://pubmed.ncbi.nlm.nih.gov/24169315
https://pubmed.ncbi.nlm.nih.gov/24169315