Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mie Sakata"'
Autor:
Muhammad Myn Uddin, Izumi Ohigashi, Ryo Motosugi, Tomomi Nakayama, Mie Sakata, Jun Hamazaki, Yasumasa Nishito, Immanuel Rode, Keiji Tanaka, Tatsuya Takemoto, Shigeo Murata, Yousuke Takahama
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Foxn1 is involved in thymic epithelial cell (TEC) and CD8+T cell development. Here the authors show this development requires Foxn1 binding proximal to, and inducing transcription of, the gene encoding β5t in cortical TECs.
Externí odkaz:
https://doaj.org/article/da7be85cf2f6425ca21a3d52a9dcec58
Autor:
Izumi Ohigashi, Saulius Zuklys, Mie Sakata, Carlos E. Mayer, Yoko Hamazaki, Nagahiro Minato, Georg A. Hollander, Yousuke Takahama
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1432-1443 (2015)
Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also ha
Externí odkaz:
https://doaj.org/article/c52024c5b38643ecab82ba32ba1d7864
Publikováno v:
The Journal of Immunology. 200:1382-1388
The molecular and cellular biology of thymic epithelial cells (TECs) often relies on the analysis of TECs isolated in enzymatically digested single-cell suspensions derived from mouse thymus. Many independent studies have reported that the estimated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33f18cd9785aa0126b045e694c90773
https://doi.org/10.4049/jimmunol.1701235
https://doi.org/10.4049/jimmunol.1701235
Autor:
Shigeo Murata, Mie Sakata, Jun Hamazaki, Immanuel Rode, Yousuke Takahama, Tomomi Nakayama, Keiji Tanaka, Izumi Ohigashi, Ryo Motosugi, Tatsuya Takemoto, Yasumasa Nishito, Muhammad Myn Uddin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a4fa0fc18a42b77db3705f0e825c3b
https://doaj.org/article/da7be85cf2f6425ca21a3d52a9dcec58
https://doaj.org/article/da7be85cf2f6425ca21a3d52a9dcec58
Autor:
Taisuke Nakayama, Masataka Sata, Michio Shimabukuro, Hajime Kinoshita, Mark Webster Maxfield, Shuhei Tomita, Yousuke Takahama, Toshiaki Tamaki, Tetsuya Kitagawa, Yuki Matsuoka, Yoichiro Hirata, Yasushi Yoshida, Hirotsugu Kurobe, Mie Sakata, Noriko Sugasawa, Mayuko Higashida
Publikováno v:
Cardiovascular Research. 99:705-715
Aims Excessive vascular remodelling leads to progression of a wide range of vasculopathies, and the immune response to intimal injuries is crucial in this process. This vascular remodelling occurs in the hypoxic microenvironment and is closely relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c630a9df27593ec344d6d5ecf836279
https://doi.org/10.1093/cvr/cvt146
https://doi.org/10.1093/cvr/cvt146
Publikováno v:
The Journal of Immunology. 190:5110-5117
Medullary thymic epithelial cells (mTECs) play a pivotal role in the establishment of self-tolerance in T cells by ectopically expressing various tissue-restricted self-Ags and by chemoattracting developing thymocytes. The nuclear protein Aire expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a277a332fb5351ca1871a7719a9fc470
https://doi.org/10.4049/jimmunol.1203203
https://doi.org/10.4049/jimmunol.1203203
Aire-expressing thymic medullary epithelial cells originate from beta 5t-expressing progenitor cells
Autor:
Shigeo Murata, Georg A. Holländer, Yousuke Takahama, Carlos E. Mayer, Mie Sakata, Keiji Tanaka, Izumi Ohigashi, Saulius Zuklys, Saule Zhanybekova
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
The thymus provides multiple microenvironments that are essential for the development and repertoire selection of T lymphocytes. The thymic cortex induces the generation and positive selection of T lymphocytes, whereas the thymic medulla establishes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a6584ea5700fc3e80523fb188ac093
Publikováno v:
Neuropsychopharmacology. 30:1856-1860
Rapid eye movement (REM)-sleep related changes in arterial pressure (AP) and heart rate (HR) were observed in homozygous and heterozygous adenosine A(2A) receptor (A2AR) knockout (KO) mice, and the corresponding wild-type mice. During REM sleep, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dec9f0c68893c8df0ce68a327271f50
https://doi.org/10.1038/sj.npp.1300727
https://doi.org/10.1038/sj.npp.1300727
Autor:
Izumi Ohigashi, Kazuya Kondo, Naoko Matsui, Keijirou Tanaka, Ryuji Kaji, Yoshiko Nomura, Takahiro Furukawa, Mie Sakata, Yasushi Nakagawa, Sumimasa Yamashita, Yousuke Takahama, Tetsuya Kitagawa
Publikováno v:
Journal of neuroimmunology. 269(1-2)
The thymus is implicated as an organ that contributes to autoimmunity in myasthenia gravis (MG) patients. Hassall's corpuscles (HCs) are assumed to represent the terminally differentiated stage of medullary thymic epithelial cells (mTECs). By using m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319adecb16db9988ff887aea638f7bd6
https://pubmed.ncbi.nlm.nih.gov/24556356
https://pubmed.ncbi.nlm.nih.gov/24556356
Autor:
Naomi Eguchi, J. Stephen Fink, Wei-Min Qu, Jiang-Fan Chen, Osamu Hayaishi, Michael A. Schwarzschild, Mie Sakata, Zhi-Li Huang, Yoshihiro Urade
Publikováno v:
Neurology. 61:S94-S96
Adenosine is proposed to be an endogenous sleep-promoting substance based on the results of a variety of pharmacologic and behavioral experiments.1 For example, sleep is induced in rats after administration of metabolically stable adenosine analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77bd6980fe86848f0bfaa1f2041fe4b9
https://doi.org/10.1212/01.wnl.0000095222.41066.5e
https://doi.org/10.1212/01.wnl.0000095222.41066.5e