Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mie Nishio"'
Autor:
Noriaki Maeda, Hidetsugu Murai, Kouji Hattori, Osamu Okitsu, Mie Nishio, Akira Tanaka, Yasunori Nagakura, Jiro Seki, Kiyoshi Taniguchi, Seiichiro Tabuchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4861-4864
The synthesis and biological activity of novel derivatives of our previously reported IP receptor agonist FR181157 is described. SAR studies to replace the cyclohexene-linker of FR181157 led to the discovery of compound 1i (FR207845) as a potent non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4efd82720f835265bae5de973b766e4
https://doi.org/10.1016/j.bmcl.2006.06.076
https://doi.org/10.1016/j.bmcl.2006.06.076
Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5
Autor:
Jiro Seki, Kiyoshi Taniguchi, Akira Tanaka, Kouji Hattori, Hisashi Takasugi, Fujiko Takamura, Mie Nishio
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4475-4478
A metabolism study of FK788 (2) led to the discovery of new diphenylcarbamoyl derivatives as prostacyclin mimetics without the PG skeleton. We designed and evaluated PGI2 mimetics based on blocking the main metabolic pathway of FK788. The new compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721d7bc78a2411b0ca63044f84db057c
https://doi.org/10.1016/j.bmcl.2006.06.033
https://doi.org/10.1016/j.bmcl.2006.06.033
Autor:
Kouji, Hattori, Fujiko, Takamura, Akira, Tanaka, Hisashi, Takasugi, Kiyoshi, Taniguchi, Mie, Nishio, Satoshi, Koyama, Jiro, Seki, Kazuo, Sakane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3284-3287
A metabolism study of FR181157 (1) led to the discovery of new oxazole derivatives as active metabolites. The metabolite 6 with an epoxy ring exhibited high anti-aggregative potency with an IC(50) of 5.8 nM and potent binding affinity for the human r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc565e53a9c03d9516b3b2486ac467b
https://doi.org/10.1016/j.bmcl.2005.04.076
https://doi.org/10.1016/j.bmcl.2005.04.076
Autor:
Mie Nishio, Kouji Hattori, Masahide Higaki, Jiro Seki, Satoshi Koyama, Kiyoshi Taniguchi, Osamu Okitsu, Akira Tanaka, Seiichiro Tabuchi, Kazuo Sakane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3091-3095
The new classes of diphenylcarbamate derivatives with a tetrahydronaphthalene skeleton as highly potent and selective IP agonists have been discovered. The optimized diphenylcarbamate type compound FK-788: (R)-4 exhibited potent antiaggregative poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f98561b97697802f1557bf4c6b78b7
https://doi.org/10.1016/j.bmcl.2005.04.047
https://doi.org/10.1016/j.bmcl.2005.04.047
Autor:
Yoshimi Hirasawa-Taniyama, Mie Nishio, Toshio Yamanaka, Kayoko Mihara, Yasuhiro Kita, Kiyotaka Ito, Jiro Seki, Susumu Miyata, Yasuko Kato, Seitaro Mutoh
Publikováno v:
European Journal of Pharmacology. 473:163-169
The antiplatelet and antithrombotic effects of FR171113, 3-(4-chlorophenyl)-2-(2,4-dichlorobenzoylimino)-5-(methoxycarbonyl methylene)-1,3-thiazolidin-4-one, a non-peptide protease-activated receptor 1 (PAR1) antagonist, were evaluated in guinea pigs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0119ba2a2a39f0bccc611289e2a07df
https://doi.org/10.1016/s0014-2999(03)01973-3
https://doi.org/10.1016/s0014-2999(03)01973-3
Autor:
Yasuko Kato, Mie Nishio, Toshio Yamanaka, Yukio Motoyama, Jiro Seki, Yoshimi Hirasawa, Kiyotaka Ito, Yasuhiro Kita
Publikováno v:
European Journal of Pharmacology. 384:197-202
Synthetic peptides (5 to 14 amino acids), identical in sequence to the new amino-terminus of the thrombin receptor generated following cleavage by thrombin, act as thrombin receptor agonist peptides. Whilst thrombin receptor antagonist peptides are k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a17f281a12ca70b099b694ca66c5cc
https://doi.org/10.1016/s0014-2999(99)00658-5
https://doi.org/10.1016/s0014-2999(99)00658-5
Autor:
Mie Nishio
Publikováno v:
Japanese journal of MHTS. 24:49-55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c075e3accabbbc9446502e7cb0f9ae63
https://doi.org/10.7143/jhep1985.24.49
https://doi.org/10.7143/jhep1985.24.49
Publikováno v:
Atherosclerosis. 117:97-106
The effect of FK409, a new nitric-oxide (NO) donor, on neointimal formation of rat carotid arteries following balloon injury was studied. The intimal thickening at 14 days was strongly suppressed by twice daily administration of FK409 at 10 mg/kg fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754002fbf3c4102d231fd8deb0563f4e
https://doi.org/10.1016/0021-9150(95)05563-c
https://doi.org/10.1016/0021-9150(95)05563-c
Publikováno v:
Atherosclerosis. 108:159-165
The effect of TFC-612, methyl-6-[{(1 R ,2 S ,3 R )-3hydroxy-2-{(l E ,3 S ,5 R )-3-hydroxy-5-methyl-l-nonenyl}-5-oxocyclopentyl}thio] hexanoate, on intimal thickening of carotid artery 14 days after endothelium denudation with a balloon catheter was e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ff0198b060b6a72c571a4a2f6d7061b
https://doi.org/10.1016/0021-9150(94)90110-4
https://doi.org/10.1016/0021-9150(94)90110-4
Publikováno v:
European Journal of Pharmacology. 257:123-130
(±)-( E )-Ethyl-2-[( E )-hydroxyimino]-5-nitro-3-hexeneamide (FK409), which was isolated from microbial products, has been reported to show a vasorelaxant effect through a mechanism similar to that of the organic nitrates such as isosorbide dinitrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246a914385f10a3917f0306bb46090dd
https://doi.org/10.1016/0014-2999(94)90703-x
https://doi.org/10.1016/0014-2999(94)90703-x