Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots

Autor: Lars R. Ingerslev, Ida Donkin, Odile Fabre, Soetkin Versteyhe, Mie Mechta, Pattarawan Pattamaprapanont, Brynjulf Mortensen, Nikolaj Thure Krarup, Romain Barrès

Publikováno v: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)

Abstract Remodeling of the sperm epigenome by lifestyle factors before conception could account for altered metabolism in the next generation offspring. Here, we hypothesized that endurance training changes the epigenome of human spermatozoa. Using s

Externí odkaz: https://doaj.org/article/04d3e7db839c4df1b84cb57f45f3af4a

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

Autor: Juleen R. Zierath, Emil V. R. Appel, Torben Hansen, Soetkin Versteyhe, Romain Barrès, Loa Nordkap, Ida Donkin, Brynjulf Mortensen, Christopher T. Workman, Viggo B. Kristiansen, Niels Jørgensen, Lars R. Ingerslev, Mie Mechta, Kui Qian

Publikováno v: Donkin, I, Versteyhe, S, Ingerslev, LR, Qian, K, Mechta, M, Nordkap, L, Mortensen, B, Appel, EVR, Jørgensen, N, Kristiansen, VB, Hansen, T, Workman, C, Zierath, JR & Barrès, R 2016, ' Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans ', Cell Metabolism, vol. 23, no. 2, pp. 369–378 . https://doi.org/10.1016/j.cmet.2015.11.004

Obesity is a heritable disorder, with children of obese fathers at higher risk of developing obesity. Environmental factors epigenetically influence somatic tissues, but the contribution of these factors to the establishment of epigenetic patterns in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ab23018a1f001291cbac928adc37e8
https://doi.org/10.1016/j.cmet.2015.11.004

Chronic erythropoietin treatment improves diet-induced glucose intolerance in rats

Autor: Andreas N. Madsen, Catherine Bisbal, Patricia A. Ruell, Jacques Mercier, Romain Barrès, Emilie Mas, David Simar, H. Ainge, Trevor A. Mori, Corinne Caillaud, Mie Mechta, Stephen M. Twigg

Publikováno v: Journal of Endocrinology
Journal of Endocrinology, BioScientifica, 2015, 225 (2), pp.77-88. ⟨10.1530/JOE-15-0010⟩

Erythropoietin (EPO) ameliorates glucose metabolism through mechanisms not fully understood. In this study, we investigated the effect of EPO on glucose metabolism and insulin signaling in skeletal muscle. A 2-week EPO treatment of rats fed with a hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eccd7f1d5871d1c95a77c3bd1de094f
https://doi.org/10.1530/joe-15-0010

No influence of OPG and its ligands, RANKL and TRAIL, on proliferation and regulation of the calcification process in primary human vascular smooth muscle cells

Autor: Birgitte Hviid Mumm, Vibe Skov, Mie Mechta, Lars Melholt Rasmussen, Malene Olesen

Publikováno v: Olesen, M, Skov, V, Mechta, M, Mumm, B H & Rasmussen, L M 2012, ' No influence of OPG and its ligands, RANKL and TRAIL, on proliferation and regulation of the calcification process in primary human vascular smooth muscle cells ', Molecular and Cellular Endocrinology, vol. 362, no. 1-2, pp. 149-56 . https://doi.org/10.1016/j.mce.2012.06.004

The aim of this study was to examine the effects of the OPG-RANKL-TRAIL system on proliferation, regulation of calcification-associated genes and calcification of human vascular smooth muscle cells (HVSMCs). Small interfering (si)RNA-mediated knockdo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b93fe9b27a65667e127d1b5ad041254
https://doi.org/10.1016/j.mce.2012.06.004