Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mie Linder Hübbe"'
Autor:
Olivia Lie-Andersen, Mie Linder Hübbe, Krishanthi Subramaniam, Daniel Steen-Jensen, Ann Christina Bergmann, Daniel Justesen, Morten Orebo Holmström, Lance Turtle, Sune Justesen, Telma Lança, Morten Hansen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Induction of a lasting protective immune response is dependent on presentation of epitopes to patrolling T cells through the HLA complex. While peptide:HLA (pHLA) complex affinity alone is widely exploited for epitope selection, we demonstrate that i
Externí odkaz:
https://doaj.org/article/93081d72d7b44f6aafc8a1eb021bf08a
Autor:
Marco Donia, Mads Hald Andersen, Lars Grøntved, Daniel Hargbøl Madsen, Inés Lecoq, Evelina Martinenaite, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum, Lucia Lara de la Torre, Simone Kloch Bendtsen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Pancreatic ductal adenocarcinoma (PDAC) is associated with very poor survival, making it the third and fourth leading cause of all cancer-related deaths in the USA and European Union, respectively. The tumor microenvironment (TME) in PDAC
Externí odkaz:
https://doaj.org/article/9b7ffc36e9674c6099fd906a29e40d4b
Autor:
Simone Kloch Bendtsen, Maria Perez-Penco, Mie Linder Hübbe, Evelina Martinenaite, Morten Orebo Holmström, Stine Emilie Weis-Banke, Nicolai Grønne Dahlager Jørgensen, Mia Aaboe Jørgensen, Shamaila Munir Ahmad, Kasper Mølgaard Jensen, Christina Friese, Mia Thorup Lundsager, Astrid Zedlitz Johansen, Marco Carretta, Niels Ødum, Özcan Met, Inge Marie Svane, Daniel Hargbøl Madsen, Mads Hald Andersen
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Galectin-3 (Gal3) can be expressed by many cells in the tumor microenvironment (TME), including cancer cells, cancer-associated fibroblasts, tumor-associated macrophages, and regulatory T cells (Tregs). In addition to immunosuppression, Gal3 expressi
Externí odkaz:
https://doaj.org/article/4a88182fd3824e069baeb2dcda39bf1d
Autor:
Marco Donia, Mads Hald Andersen, Özcan Met, Lars Grøntved, Daniel Hargbøl Madsen, Inge Marie Svane, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)
Background High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME). Depletion of L-Arg has de
Externí odkaz:
https://doaj.org/article/fff8e87a81a74470aaa2d8cac2b4d443
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Adoptive cell therapy (ACT), based on treatment with autologous tumor infiltrating lymphocyte (TIL)-derived or genetically modified chimeric antigen receptor (CAR) T cells, has become a potentially curative therapy for subgroups of patients with mela
Externí odkaz:
https://doaj.org/article/8ce0c3bd309b4387a6524aeba9b2f69e
Autor:
Stine Emilie Weis-Banke, Mie Linder Hübbe, Morten Orebo Holmström, Mia Aaboe Jørgensen, Simone Kloch Bendtsen, Evelina Martinenaite, Marco Carretta, Inge Marie Svane, Niels Ødum, Ayako Wakatsuki Pedersen, Özcan Met, Daniel Hargbøl Madsen, Mads Hald Andersen
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2). Here we describe the existence of pro-inflammatory effector T-cells that recognize ARG2 and can directly target
Externí odkaz:
https://doaj.org/article/ea0ac61138cc45ada890530c9c9af0c1
Autor:
Mads Hald Andersen, Vincenzo Bronte, Ayako Wakatsuki Pedersen, Daniel Hargbøll Madsen, Mai-Britt Zocca, Manuela Iezzi, Cristina Frusteri, Francesco De Sanctis, Annalisa Adamo, Marion Chapellier, Katharina Kopp, Evelina Martinenaite, Stine Emilie Weis-Banke, Maria Perez-Penco, Marco Carretta, Mie Linder Hübbe, Stefano Ugel, Mia Aaboe Jørgensen
Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells. Increased activity of ARG1 promotes the formation of an immunosuppressive microenvironment and leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666a35b5cf78d8cf2f4835377ed3e14d
https://doi.org/10.1158/2326-6066.c.6550574
https://doi.org/10.1158/2326-6066.c.6550574
Autor:
Stine Emilie Weis-Banke, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Morten Orebo Holmström, Mia Aaboe Jørgensen, Inge Marie Svane, Özcan Met, Niels Ødum, Daniel Hargbøl Madsen, Marco Donia, Lars Grøntved, Mads Hald Andersen
Publikováno v:
Weis-Banke, S E, Lisle, T L, Perez-Penco, M, Schina, A, Hübbe, M L, Siersbæk, M, Holmström, M O, Jørgensen, M A, Marie Svane, I, Met, Ö, Ødum, N, Madsen, D H, Donia, M, Grøntved, L & Andersen, M H 2022, ' Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells ', Journal for ImmunoTherapy of Cancer, vol. 10, no. 10, e005326 . https://doi.org/10.1136/jitc-2022-005326
BackgroundHigh expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME). Depletion of L-Arg has det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a3e11990a28f3476ee2a8fc7032848
https://curis.ku.dk/ws/files/327473121/e005326.full.pdf
https://curis.ku.dk/ws/files/327473121/e005326.full.pdf
Autor:
Maria Perez-Penco, Stine Emilie Weis-Banke, Aimilia Schina, Majken Siersbæk, Mie Linder Hübbe, Mia Aaboe Jørgensen, Inés Lecoq, Lucia Lara de la Torre, Simone Kloch Bendtsen, Evelina Martinenaite, Morten Orebo Holmström, Daniel Hargbøl Madsen, Marco Donia, Niels Ødum, Lars Grøntved, Mads Hald Andersen
Publikováno v:
Perez-Penco, M, Weis-Banke, S E, Schina, A, Siersbæk, M, Hübbe, M L, Jørgensen, M A, Lecoq, I, Lara De La Torre, L, Bendtsen, S K, Martinenaite, E, Holmström, M O, Madsen, D H, Donia, M, Ødum, N, Grøntved, L & Andersen, M H 2022, ' TGFβ-derived immune modulatory vaccine : targeting the immunosuppressive and fibrotic tumor microenvironment in a murine model of pancreatic cancer ', Journal for ImmunoTherapy of Cancer, vol. 10, no. 12, e005491 . https://doi.org/10.1136/jitc-2022-005491
BackgroundPancreatic ductal adenocarcinoma (PDAC) is associated with very poor survival, making it the third and fourth leading cause of all cancer-related deaths in the USA and European Union, respectively. The tumor microenvironment (TME) in PDAC i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36be4ae741c59590b2536083269cb2c0
https://curis.ku.dk/portal/da/publications/tgfderived-immune-modulatory-vaccine(61aa1a7f-8a6c-48d8-83fa-76e195bc0044).html
https://curis.ku.dk/portal/da/publications/tgfderived-immune-modulatory-vaccine(61aa1a7f-8a6c-48d8-83fa-76e195bc0044).html
Autor:
Evelina Martinenaite, Annalisa Adamo, Stine Emilie Weis-Banke, Katharina L. Kopp, Maria Perez-Penco, Stefano Ugel, Marion Chapellier, Vincenzo Bronte, Mie Linder Hübbe, Cristina Frusteri, Marco Carretta, Mia Aaboe Jørgensen, Mai-Britt Zocca, Francesco De Sanctis, Ayako Wakatsuki Pedersen, Manuela Iezzi, Mads Hald Andersen, Daniel Hargbøll Madsen
Publikováno v:
Cancer immunology research. 9(11)
Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells. Increased activity of ARG1 promotes the formation of an immunosuppressive microenvironment and leads