Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Middleton Brawner Floyd"'
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The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)
Autor: Xin Han, Charles Ingalls, Russell Dushin, Middleton Brawner Floyd, Thomas Nittoli, Katherine Cheung, Yongbo Hu, K T Arndt, G. Grosu, Bing Guo, Heidi L. Fraser, Allan Wissner, Andrea Olland
Publikováno v: European Journal of Medicinal Chemistry. 45:1379-1386
A series of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamine-based inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1) has been identified. Several examples appear to be potent and relatively selective inhibito
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a386fbdfbe585a340f415a4ed8d9f4f
https://doi.org/10.1016/j.ejmech.2009.12.036
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2
Benzo[c][2,7]naphthyridines as inhibitors of PDK-1
Autor: Russell Dushin, Allan Wissner, Yanong D. Wang, Andrea Olland, Kyung-Hee Kim, Heidi L. Fraser, Bing Guo, K T Arndt, Yongbo Hu, Middleton Brawner Floyd
Publikováno v: Bioorganicmedicinal chemistry letters. 19(17)
A series of substituted benzo[c][2,7]-naphthyridines were prepared and showed good potency in inhibiting PDK-1. The synthesis and SAR of this series of compounds are presented as well as the X-ray crystal structure of one of these analogs in a comple
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5027ee645e04336996ec000ecfa89990
https://pubmed.ncbi.nlm.nih.gov/19628388
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3
4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors
Autor: Nancy Torres, Inder Chaudhary, Dan Maarten Berger, Middleton Brawner Floyd, Steven C. Kim, Larry Feldberg, Donald Wojciechowicz, Dennis Powell, Karen Collins, Robert Mallon, Minu Dutia
Publikováno v: Bioorganicmedicinal chemistry. 16(20)
A series of substituted 7-alkenyl 4[3-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)]anilino-3-quinolinecarbonitrile analogs were synthesized and evaluated as MEK1 kinase inhibitors. The synthetic details, structure–activity relationships, biological
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61453aa498eb019fa03b36bd83ab9b0e
https://pubmed.ncbi.nlm.nih.gov/18815050
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5
Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors
Autor: Biqi Wu, Nan Zhang, Middleton Brawner Floyd, Dennis Powell, Lourdes Toral-Barza, Eleonora D. Kovacs, Constance Kohler, Allan Wissner
Publikováno v: Bioorganicmedicinal chemistry letters. 10(24)
A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd5e98d48048ca5d3c7b0bc950acef3
https://pubmed.ncbi.nlm.nih.gov/11133101
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8
ChemInform Abstract: A SYNTHESIS OF 2-(6′-CARBOXY-2′-CIS-HEXENYL)-4-HYDROXYCYCLOPENT-2-EN-1-ONE, A PROSTAGLANDIN INTERMEDIATE
Autor: Middleton Brawner Floyd
Publikováno v: Chemischer Informationsdienst. 6
Several recent publications2 report the synthesis of prostaglandin E1 (PGE1, 2) and some of its derivatives by conjugate addition reactions to ether-ester forms of hydroxycyclopentenone acid 1.3 The simplicity of this approach makes its application t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::685cfdc6063690a26b8c75dc3170a1f7
https://doi.org/10.1002/chin.197513434
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