Three-dimensional FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells

Autor: Müller, Andreas, Schmidt, Deborah, Xu, C. Shan, Pang, Song, D'Costa, Jolson Verner, Kretschmar, Susanne, Münster, Carla, Kurth, Thomas, Jug, Florian, Weigert, Martin, Hess, Harald F., Solimena, Michele

Microtubules play a major role in intracellular trafficking of vesicles in endocrine cells. Detailed knowledge of microtubule organization and their relation to other cell constituents is crucial for understanding cell function. However, their role i

Externí odkaz: https://tud.qucosa.de/id/qucosa%3A73356
https://tud.qucosa.de/api/qucosa%3A73356/attachment/ATT-0/

Nano-positioning and tubulin conformation contribute to axonal transport regulation of mitochondria along microtubules

Autor: Valérie Van Steenbergen, Flavie Lavoie-Cardinal, Youcef Kazwiny, Marianna Decet, Tobie Martens, Patrik Verstreken, Werend Boesmans, Paul De Koninck, Pieter Vanden Berghe

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 119(45):e2203499119. National Academy of Sciences

Correct spatiotemporal distribution of organelles and vesicles is crucial for healthy cell functioning and is regulated by intracellular transport mechanisms. Controlled transport of bulky mitochondria is especially important in polarized cells such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9395b6f98762a69c601c751c1536f49c
https://pubmed.ncbi.nlm.nih.gov/36322761

Local changes in microtubule network mobility instruct neuronal polarization and axon specification

Autor: Burute, Mithila, Jansen, Klara I, Mihajlovic, Marko, Vermonden, Tina, Kapitein, Lukas C, Celbiologie, Pharmaceutics, Sub Cell Biology, Afd Pharmaceutics

Publikováno v: Science advances, 8(44), 1. American Association for the Advancement of Science

The polarization of neurons into axons and dendrites depends on extracellular cues, intracellular signaling, cytoskeletal rearrangements, and polarized transport, but the interplay between these processes during polarization remains unresolved. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893277c265b6c5e151f5240221af6560
https://pubmed.ncbi.nlm.nih.gov/36332030

Re‐evaluating the actin‐dependence of spectraplakin functions during axon growth and maintenance

Autor: Yue Qu, Natalia Sanchez-Soriano, Jill Parkin, Ines Hahn, Andreas Prokop, Kriti Gupta, Juliana Alves-Silva

Publikováno v: Developmental Neurobiology
Qu, Y, Alves-Silva, J, Gupta, K, Hahn, I, Parkin, J, Sanchez-Soriano, N & Prokop, A 2022, ' Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenance ', Developmental Neurobiology, vol. 82, no. 4, pp. 288-307 . https://doi.org/10.1002/dneu.22873

Axons are the long and slender processes of neurons constituting the biological cables that wire the nervous system. The growth and maintenance of axons require bundles of microtubules that extend through their entire length. Understanding microtubul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c5c217c94ffd451d4235bea0d71e4e
http://livrepository.liverpool.ac.uk/3151921/1/Qu+al.pdf

Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons

Autor: Judith B Fuelle, André Voelzmann, Laura Anne Lowery, Ines Hahn, Andreas Prokop, Natalia Sanchez-Soriano, Paula G. Slater, Jill Parkin

Publikováno v: PLoS Genetics, Vol 17, Iss 7, p e1009647 (2021)
Hahn, I, Voelzmann, A, Parkin, J, Fülle, J B, Slater, P G, Lowery, L A, Sanchez-Soriano, N & Prokop, A 2021, ' Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons ', PLoS Genetics, vol. 17, no. 7, 1009647 . https://doi.org/10.1371/journal.pgen.1009647
PLoS Genetics
PLOS GENETICS

The formation and maintenance of microtubules requires their polymerisation, but little is known about how this polymerisation is regulated in cells. Focussing on the essential microtubule bundles in axons of Drosophila and Xenopus neurons, we show t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17abca2879f65f60eb95a33dfe6642b
https://doaj.org/article/c5e8e8f422334f6baa0209cb9072db39