Výsledky vyhledávání - "Microtubule-Associated Proteins/genetics/metabolism"

Autor: Meraldi, Patrick

Publikováno v: European Journal of Cell Biology, Vol. 91, No 2 (2012) pp. 103-6

The multiple functions of kinetochores are reflected in their complex composition, with over a hundred different proteins, which self-associate in several functional subcomplexes. Most of these kinetochore proteins were identified over the last 10-12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::557a4360fb9a1a3d7c825545f99b1b89
https://archive-ouverte.unige.ch/unige:28852

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The DISC1 Pathway Modulates Expression of Neurodevelopmental, Synaptogenic and Sensory Perception Genes

Autor: David J. Porteous, William Hennah

Publikováno v: PLoS ONE
PLoS ONE, Vol 4, Iss 3, p e4906 (2009)
Hennah, W & Porteous, D 2009, ' The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes ', PLoS ONE, vol. 4, no. 3, pp. e4906 . https://doi.org/10.1371/journal.pone.0004906

BACKGROUND: Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder. There is evidence for genetic interplay between variants in DISC1 and in biologically int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a2107240480d77fca3000cdc2c1867
http://europepmc.org/articles/PMC2654149

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Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier

Autor: Cardinale, S., Bergmann, J. H., Kelly, D., Nakano, M., Valdivia, M. M., Kimura, Hiroshi, Masumoto, H., Larionov, V., Earnshaw, W. C.

Publikováno v: Cardinale, S, Bergmann, J H, Kelly, D, Nakano, M, Valdivia, M M, Kimura, H, Masumoto, H, Larionov, V & Earnshaw, W C 2009, ' Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier ', Molecular Biology of the Cell, vol. 20, no. 19, pp. 4194-204 . https://doi.org/10.1091/mbc.E09-06-0489

We previously used a human artificial chromosome (HAC) with a synthetic kinetochore that could be targeted with chromatin modifiers fused to tetracycline repressor to show that targeting of the transcriptional repressor tTS within kinetochore chromat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd3db1e94a2005511b5940674a88194
https://hdl.handle.net/20.500.11820/98fac1a1-36f2-4e6a-9e0f-e5ed8c02301b

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Autor: Yaping Xu, Hanqing Cai, Jinning Lou, Wenjian Zhang, Shiqin Xu, Mi Li, Xiuli Men, Claes B. Wollheim, Wenying Yang, Li-ya Ye, Haiyan Wang

Publikováno v: International Journal of Biochemistry & Cell Biology, Vol. 41, No 4 (2009) pp. 879-90

The pancreatic beta cell dysfunction is critical cycle in the pathogenesis of diabetes. Hyperglycemia is one of factors that induce pancreatic beta cell dysfunction, but the underlying mechanisms have not been well elucidated. In this study, we repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e12827e32150d0b042a740989277647
https://pubmed.ncbi.nlm.nih.gov/18805504

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The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent

Autor: Hannak, E., Oegema, K., Kirkham, M., Gönczy, P., Habermann, B., Hyman, A. A.

Publikováno v: The Journal of cell biology, vol 157, iss 4

gamma-Tubulin-containing complexes are thought to nucleate and anchor centrosomal microtubules (MTs). Surprisingly, a recent study (Strome, S., J. Powers, M. Dunn, K. Reese, C.J. Malone, J. White, G. Seydoux, and W. Saxton. Mol. Biol. Cell. 12:1751-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::df1e572d1a5ff9b6c1aed93b87242633
https://escholarship.org/uc/item/6cz745f3

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Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo

Autor: Pierre Gönczy, Silke Pichler, Anthony A. Hyman, Matthew Kirkham

Publikováno v: Karolinska Institutet
The Journal of Cell Biology

We have investigated the role of cytoplasmic dynein in microtubule organizing center (MTOC) positioning using RNA-mediated interference (RNAi) in Caenorhabditis elegans to deplete the product of the dynein heavy chain gene dhc-1. Analysis with time-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e75ad2bd4c47a0fff3d6872f13d56fc
http://www.ncbi.nlm.nih.gov/pubmed/10508861

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