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Theabrownin inhibits the cytoskeleton‑dependent cell cycle, migration and invasion of human osteosarcoma cells through NF‑κB pathway‑related mechanisms

Autor: Qiang Yuan, Wangdong Jin, Xinyu Yang, Letian Shan, Zhang Jin, Mengyuan Gui, Xiaoqiao Dong, Li Zhou, Chaoqun Gu, Jie Chen

Publikováno v: Oncology Reports

Considering the high metastatic potential of osteosarcoma, not only pro‑apoptosis, but also anti‑metastasis is important for anti‑osteosarcoma therapy. Previously, the authors reported the pro‑apoptotic and tumor‑inhibitory effects of theab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a479459a120948ac656b94e7a65913a
https://doi.org/10.3892/or.2020.7801

High-resolution imaging reveals how the spindle midzone impacts chromosome movement

Autor: Lina Carlini, Tarun M. Kapoor, Melissa C. Pamula, Priyanka Verma, Scott Forth, Subbulakshmi Suresh, Wesley R. Legant, Alexey Khodjakov, Eric Betzig

Publikováno v: The Journal of Cell Biology

Microtubule bundles in the spindle midzone have been reported to either promote or hinder chromosome movement. Pamula et al. examine the assembly dynamics of midzone microtubule bundles during anaphase and how chromosome segregation is impacted by ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1295522c257bc0c96de4807df1130369
https://doi.org/10.1083/jcb.201904169

Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing

Autor: Hannie Kremer, Kevin K. Ohlemiller, Staci M. Rakowiecki, Christian Gilissen, Jiddeke M. van de Kamp, Erdi Kucuk, Alex M Rohacek, Jeroen Smits, Jaap Oostrik, Amir Nankali, John S. Oghalai, Benjamin L. Prosser, Douglas J. Epstein, Klaus H. Kaestner, Tingfang Chen, Cornelis P. Lanting, Matthew A. Caporizzo, Ronald J.E. Pennings

Publikováno v: Developmental Cell, 56, 10, pp. 1526-1540.e7
Dev Cell
Developmental Cell, 56, 1526-1540.e7
Chen, T, Rohacek, A M, Caporizzo, M, Nankali, A, Smits, J J, Oostrik, J, Lanting, C P, Kücük, E, Gilissen, C, van de Kamp, J M, Pennings, R J E, Rakowiecki, S M, Kaestner, K H, Ohlemiller, K K, Oghalai, J S, Kremer, H, Prosser, B L & Epstein, D J 2021, ' Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing ', Developmental Cell, vol. 56, no. 10, pp. 1526-1540.e7 . https://doi.org/10.1016/j.devcel.2021.04.017
Developmental Cell, 56(10), 1526-1540.e7. Cell Press

In mammals, sound is detected by mechanosensory hair cells that are activated in response to vibrations at frequency-dependent positions along the cochlear duct. We demonstrate that inner ear supporting cells provide a structural framework for transm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dee4d64f9b711a9482e5c2b2919c854
https://repository.ubn.ru.nl/handle/2066/233882

TheTrypanosoma bruceisubpellicular microtubule array is organized into functionally discrete subdomains defined by microtubule associated proteins

Autor: Amanda E. Ruiz, Thomas E. Sladewski, Christopher L. de Graffenried, Christine T. Huynh, Amy N. Sinclair, Jenna Zuromski

Microtubules are inherently dynamic cytoskeletal polymers whose length and activity can be altered to perform essential functions in eukaryotic cells, such as providing tracks for intracellular trafficking and forming the mitotic spindle. Microtubule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ded3cde4021ff42e4fadee8ed1ee1505
https://doi.org/10.1101/2020.11.09.375725