Výsledky vyhledávání - "Microtubule assembly"

Akademický článek

Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6

Autor: Fanomezana Moutse Ranaivoson, Vincent Crozet, Matthieu P. M. H. Benoit, Amna Abdalla Mohammed Khalid, Carlos Kikuti, Helena Sirkia, Ahmed El Marjou, Stéphanie Miserey-Lenkei, Ana B. Asenjo, Hernando Sosa, Christoph F. Schmidt, Steven S. Rosenfeld, Anne Houdusse

Publikováno v: Open Biology, Vol 13, Iss 9 (2023)

KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling between the nucleotide- and microtubule-binding sites of this kinesin

Externí odkaz: https://doaj.org/article/d507f9c467904d2fad8c1e25083b89b1

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Akademický článek

Weed populations in the main cultures of Luxembourg: control options and monitoring in a complex environmental and political framework

Autor: Treer, Sergiu, Colbus, Moritz, Steiger, Simon, Eickermann, Michael, Hoffmann, Lucien, Beyer, Marco

Publikováno v: Julius-Kühn-Archiv, Vol 464, Pp 64-71 (2020)

Due to ecotoxicological and environmental reasons, chemical treatments for weed control are under discussion. To help farmers in coping with challenges imposed by restricted herbicide availability, projects on using modified crop rotations for reduci

Externí odkaz: https://doaj.org/article/6fd94dd43fb94825b30aad031b378eb7

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Akademický článek

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Akademický článek

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Akademický článek

Abnormal Phosphorylation of Tau and the Mechanism of Alzheimer Neurofibrillary Degeneration: Sequestration of Microtubule-Associated Proteins 1 and 2 and the Disassembly of Microtubules by the Abnormal Tau

Autor: Grundke-Iqbal, Inge, Barra, Héctor S., Iqbal, Khalid

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1997 Jan 01. 94(1), 298-303.

Externí odkaz: https://www.jstor.org/stable/41490

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Akademický článek

CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells

Autor: Toya, Mika, Kobayashi, Saeko, Kawasaki, Miwa, Shioi, Go, Kaneko, Mari, Ishiuchi, Takashi, Misaki, Kazuyo, Meng, Wenxiang, Takeichi, Masatoshi

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2016 Jan 01. 113(2), 332-337.

Externí odkaz: https://www.jstor.org/stable/26467359

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Akademický článek

Changes in microtubule-associated protein tau during peripheral nerve injury and regeneration

Autor: Guang-bin Zha, Mi Shen, Xiao-song Gu, Sheng Yi

Publikováno v: Neural Regeneration Research, Vol 11, Iss 9, Pp 1506-1511 (2016)

Tau, a primary component of microtubule-associated protein, promotes microtubule assembly and/or disassembly and maintains the stability of the microtubule structure. Although the importance of tau in neurodegenerative diseases has been well demonstr

Externí odkaz: https://doaj.org/article/9df0bda6838c42f6bd530be553c76b7f

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Histology and Cell Biology: An Introduction to Pathology 5th Edition 2020

Autor: Laura Tres, Abraham L. Kierszenbaum

Publikováno v: Morphologia. 15:92-98

Linking basic science to clinical application throughout, Histology and Cell Biology: An Introduction to Pathology, 5th Edition, helps students build a stronger clinical knowledge base in the challenging area of pathologic abnormalities. This award-w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::388958b6cbe89f034c06747c642cc547
https://doi.org/10.26641/1997-9665.2021.1.92-98

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Regulation of microtubule dynamics, mechanics and function through the growing tip

Autor: Nikita Gudimchuk, J. Richard McIntosh

Publikováno v: Nature Reviews Molecular Cell Biology. 22:777-795

Microtubule dynamics and their control are essential for the normal function and division of all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic microtubule tips, which can bind to various intracellular targets, g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6eac61920bcd10534d729c81792c424d
https://doi.org/10.1038/s41580-021-00399-x

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Structural insights into targeting of the colchicine binding site by ELR510444 and parbendazole to achieve rational drug design

Autor: Jing-Hong Xian, Jia-Hong Lei, Hai Chen, Qian Lei, Lingling Ma, Yanyan Wang, Jian-Jian Zhou, Yuyan Li, Hao Chen, Yuxi Wang

Publikováno v: RSC Advances. 11:18938-18944

Microtubules consisting of α- and β-tubulin heterodimers have proven to be an efficient drug target for cancer therapy. A broad range of agents, including ELR510444 and parbendazole, can bind to tubulin and interfere with microtubule assembly. ELR5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31923f1f0f3ffb0a7ce52554c1bf7016
https://doi.org/10.1039/d1ra01173a

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