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pro vyhledávání: '"Microsomal ethanol oxidizing system"'
Akademický článek
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Autor:
Manuela G. Neuman, Helmut Karl Seitz, Samuel W. French, Stephen Malnick, Heidekazu Tsukamoto, Lawrence B. Cohen, Paula Hoffman, Boris Tabakoff, Michael Fasullo, Laura E. Nagy, Pamela L. Tuma, Bernd Schnabl, Sebastian Mueller, Jennifer L. Groebner, French A. Barbara, Jia Yue, Afifiyan Nikko, Mendoza Alejandro, Tillman Brittany, Vitocruz Edward, Kylie Harrall, Laura Saba, Opris Mihai
Publikováno v:
Biomedicines, Vol 8, Iss 3, p 63 (2020)
The following review article presents clinical and experimental features of alcohol-induced liver disease (ALD). Basic aspects of alcohol metabolism leading to the development of liver hepatotoxicity are discussed. ALD includes fatty liver, acute alc
Externí odkaz:
https://doaj.org/article/55bb8d22f29247d8b0b4e7e71397ea54
Autor:
Rolf Teschke
Publikováno v:
Biomedicines, Vol 7, Iss 3, p 68 (2019)
The spectrum of alcoholic liver disease (ALD) is broad and includes alcoholic fatty liver, alcoholic steatohepatitis, alcoholic hepatitis, alcoholic fibrosis, alcoholic cirrhosis, and alcoholic hepatocellular carcinoma, best explained as a five-hit s
Externí odkaz:
https://doaj.org/article/9cda0e747fe4487e84e7a6c0d65edb77
Autor:
Rolf Teschke
Publikováno v:
Biomedicines, Vol 6, Iss 4, p 106 (2018)
Alcoholic liver disease is the result of cascade events, which clinically first lead to alcoholic fatty liver, and then mostly via alcoholic steatohepatitis or alcoholic hepatitis potentially to cirrhosis and hepatocellular carcinoma. Pathogenetic ev
Externí odkaz:
https://doaj.org/article/cda9ba226ff44078a470dc04d3f441b5
Autor:
Jennifer L. Groebner, Laura E. Nagy, Helmut K. Seitz, Lawrence Cohen, Afifiyan Nikko, Vitocruz Edward, Samuel W. French, Sebastian Mueller, Kylie K. Harrall, Pamela L. Tuma, Manuela G. Neuman, Opris Mihai, Laura Saba, Heidekazu Tsukamoto, Mendoza Alejandro, Michael Fasullo, Paula L. Hoffman, Boris Tabakoff, Jia Yue, Stephen Malnick, French A. Barbara, Tillman Brittany, Bernd Schnabl
Publikováno v:
Biomedicines
Biomedicines, vol 8, iss 3
Biomedicines, Vol 8, Iss 3, p 63 (2020)
Biomedicines, vol 8, iss 3
Biomedicines, Vol 8, Iss 3, p 63 (2020)
The following review article presents clinical and experimental features of alcohol-induced liver disease (ALD). Basic aspects of alcohol metabolism leading to the development of liver hepatotoxicity are discussed. ALD includes fatty liver, acute alc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb24183bfae96be240540435639e6b52
http://europepmc.org/articles/PMC7148515
http://europepmc.org/articles/PMC7148515
Publikováno v:
Archives of Gastroenterology Research. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3be4043745f318bfb1b2ca6a3ee52fd
https://doi.org/10.33696/gastroenterology.2.022
https://doi.org/10.33696/gastroenterology.2.022
Autor:
Wioletta Olejarz, Piotr Tomaszewski, Grażyna Kubiak-Tomaszewska, Magdalena Mielczarek-Puta, Grażyna Nowicka, Marta Struga, Jan Pachecka
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 50(10)
Ethanol, as a small-molecule organic compound exhibiting both hydrophilic and lipophilic properties, quickly pass through the biological barriers. Over 95% of absorbed ethanol undergoes biotransformation, the remaining amount is excreted unchanged, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0df8d91ad2db4177cdf254d6ad31177
https://pubmed.ncbi.nlm.nih.gov/32338108
https://pubmed.ncbi.nlm.nih.gov/32338108
Publikováno v:
Biomedicines
Biomedicines, Vol 8, Iss 3, p 50 (2020)
Biomedicines, Vol 8, Iss 3, p 50 (2020)
Once ingested, most of the alcohol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde. Two additional pathways of acetaldehyde generation are by microsomal ethanol oxidizing system (cytochrome P450 2E1) and catalase. Acetaldehyde ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adaab54b52381f95f2bfff9f84b07f6
https://pubmed.ncbi.nlm.nih.gov/32143280
https://pubmed.ncbi.nlm.nih.gov/32143280
Autor:
Yongke Lu, Arthur I. Cederbaum
Publikováno v:
Current Pharmaceutical Design. 24:1502-1517
Alcohol consumption causes liver diseases, designated as Alcoholic Liver Disease (ALD). Because alcohol is detoxified by alcohol dehydrogenase (ADH), a major ethanol metabolism system, the development of ALD was initially believed to be due to malnut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a95928b858bcf60e03b0ec88742d00
https://doi.org/10.2174/1381612824666180410091511
https://doi.org/10.2174/1381612824666180410091511
Autor:
Rolf Teschke
Publikováno v:
Expert Opinion on Pharmacotherapy. 19:779-793
Clinicians caring for patients with alcoholic hepatitis (AH) are often confronted with the question of the best pharmacotherapy to be used.This article covers metabolic aspects of alcohol as the basis of understanding pharmacotherapy and to facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ff31a89e3bc2c0cc3e8dfe338d6877
https://doi.org/10.1080/14656566.2018.1465929
https://doi.org/10.1080/14656566.2018.1465929