Gene Expression Profile in the Sandhoff Mouse Brain with Progression of Age

Autor: Kshitiz Singh, Brianna M. Quinville, Melissa Mitchell, Zhilin Chen, Jagdeep S. Walia

Publikováno v: Genes; Volume 13; Issue 11; Pages: 2020

Sandhoff disease (SD) is a fatal neurodegenerative disorder belonging to the family of diseases called GM2 Gangliosidosis. There is no curative treatment of SD. The molecular pathogenesis of SD is still unclear though it is clear that the pathology i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ff74d20bac6e41734332a6629e463a
https://pubmed.ncbi.nlm.nih.gov/36360256

IDEAS: individual level differential expression analysis for single-cell RNA-seq data

Autor: Mengqi Zhang, Si Liu, Zhen Miao, Fang Han, Raphael Gottardo, Wei Sun

Publikováno v: Genome biology, vol. 23, no. 1, pp. 33
Genome Biology
Genome Biology, Vol 23, Iss 1, Pp 1-17 (2022)

We consider an increasingly popular study design where single-cell RNA-seq data are collected from multiple individuals and the question of interest is to find genes that are differentially expressed between two groups of individuals. Towards this en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666268c88da7466180a0a291811f9313
https://serval.unil.ch/resource/serval:BIB_B48AF13F6F91.P001/REF.pdf

Presymptomatic change in microRNAs modulates Tau pathology

Autor: Hui-Chen Lu, Xi Rao, Ines Khadimallah, Adam Williamson Corya, Yunlong Liu, Salil Sharma, Yousuf O. Ali

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific reports, vol. 8, no. 1, pp. 9251
Scientific Reports

MicroRNAs (miRs) are 18~23 nucleotides long non-coding RNAs that regulate gene expression. To explore whether miR alterations in tauopathy contribute to pathological conditions, we first determined which hippocampal miRs are altered at the presymptom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41855c806fd256fc3cb8a1f3c29cc6ed
http://link.springer.com/article/10.1038/s41598-018-27527-6

Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior

Autor: Joana F. Henriques, Renata L. Alves, Ana Magalhães, Teresa Summavielle, Teresa Canedo, Camila C. Portugal, Cátia M. Silva, João B. Relvas, Renato Socodato, Tiago Almeida, Joana Tedim-Moreira

Alcohol abuse adversely affects the lives of millions of people worldwide. Deficits in synaptic transmission and in microglial function are commonly found in human alcohol abusers and in animal models of alcohol intoxication. Here, we found that a pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5323d1d38dd85484e38fe3dc3daa066
https://hdl.handle.net/10216/140511

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

Autor: Amélie Montané, Vincent Degos, Rebecca K. Holloway, Valérie C. Besson, Olivier Baud, David H. Rowitch, Pierre Gressens, A. David Edwards, Rahma Hassan-Abdi, Henrik Hagberg, Bobbi Fleiss, Nadia Soussi-Yanicostas, Sophie Lebon, Enrico Petretto, Gareth Ball, Tifenn Le Charpentier, Fabrice Chrétien, Andrée Delahaye-Duriez, Olivier Hennebert, Zsolt Csaba, Paul Aljabar, Anne-Laure Schang, Alka Saxena, Juliette Van Steenwinckel, Veronique E. Miron, Michelle L. Krishnan, Stéphanie Sigaut, Claire Leconte, Franck Verdonk, Cindy Bokobza, Leslie Schwendimann, Walter Birchmeier

Publikováno v: Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2019, 42 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain-A Journal of Neurology, 2019, 42 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain-A Journal of Neurology, Oxford University Press (OUP), 2019, 142 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain
Brain, Vol. 142, No 12 (2019) pp. 3806-3833
Van Steenwinckel, J, Schang, A-L, Krishnan, M L, Degos, V, Delahaye-Duriez, A, Bokobza, C, Csaba, Z, Verdonk, F, Montané, A, Sigaut, S, Hennebert, O, Lebon, S, Schwendimann, L, Le Charpentier, T, Hassan-Abdi, R, Ball, G, Aljabar, P, Saxena, A, Holloway, R K, Birchmeier, W, Baud, O, Rowitch, D, Miron, V, Chretien, F, Leconte, C, Besson, V C, Petretto, E G, Edwards, A D, Hagberg, H, Soussi-Yanicostas, N, Fleiss, B & Gressens, P 2019, ' Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain ', Brain, vol. 142, no. 12, pp. 3806–3833 . https://doi.org/10.1093/brain/awz319
Van Steenwinckel, J, Schang, A-L, Krishnan, M L, Degos, V, Delahaye-Duriez, A, Bokobza, C, Csaba, Z, Verdonk, F, Montané, A, Sigaut, S, Hennebert, O, Lebon, S, Schwendimann, L, Le Charpentier, T, Hassan-Abdi, R, Ball, G, Aljabar, P, Saxena, A, Holloway, R K, Birchmeier, W, Baud, O, Rowitch, D, Miron, V, Chretien, F, Leconte, C, Besson, V C, Petretto, E G, Edwards, A D, Hagberg, H, Soussi-Yanicostas, N, Fleiss, B & Gressens, P 2019, ' Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain ', Brain : a journal of neurology, vol. 142, no. 12, pp. 3806–3833 . https://doi.org/10.1093/brain/awz319

International audience; Microglia of the developing brain have unique functional properties but how their activation states are regulated is poorly understood. Inflammatory activation of microglia in the still-developing brain of preterm-born infants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5010c4ea37526701c318b122a40130
https://www.repository.cam.ac.uk/handle/1810/301606