Minocycline fails to improve neurologic and histologic outcome after ventricular fibrillation cardiac arrest in rats

Autor: Andreas Janata, Kristin L. Schreiber, Caleb D Wilson, Ingrid A.M. Magnet, Tomas Drabek, Patrick M. Kochanek, Jason Stezoski, Keri Janesko-Feldman

Publikováno v: World Journal of Critical Care Medicine

BACKGROUND Prolonged cardiac arrest (CA) produces extensive neuronal death and microglial proliferation and activation resulting in neuro-cognitive disabilities. Among other potential mechanisms, microglia have been implicated as triggers of neuronal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d25add8cbf70b26671f3bd3e66fcd8
https://doi.org/10.5492/wjccm.v8.i7.106

TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways

Autor: Izzettin Hatip-Al-Khatib, Funda F. Bölükbaşı Hatip, Junichi Matsumoto, Fuyuko Takata, Takashi Machida, Yasufumi Kataoka, Shinya Dohgu, Atsushi Yamauchi

Publikováno v: Brain Research. 1692:34-44

Interleukin (IL)-6 is an important mediator of neurovascular dysfunction, neurodegeneration and/or neuroinflammation. We previously reported that brain pericytes released higher levels of IL-6 than did glial cells (astrocytes and microglia) in respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706aba2f546c7b20734ef8cf336638f0
https://doi.org/10.1016/j.brainres.2018.04.023

Inflammation leads to distinct populations of extracellular vesicles from microglia

Autor: Christopher J.R. Dunning, Tomas Deierborg, Bettina Hjelm Clausen, Yiyi Yang, Antonio Boza-Serrano, Kate Lykke Lambertsen

Publikováno v: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-19 (2018)
Journal of Neuroinflammation
Yang, Y, Boza-Serrano, A, Dunning, C J R, Clausen, B H, Lambertsen, K L & Deierborg, T 2018, ' Inflammation leads to distinct populations of extracellular vesicles from microglia ', Journal of Neuroinflammation, vol. 15, 168 . https://doi.org/10.1186/s12974-018-1204-7

Background Activated microglia play an essential role in inflammatory responses elicited in the central nervous system (CNS). Microglia-derived extracellular vesicles (EVs) are suggested to be involved in propagation of inflammatory signals and in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5b9f02a66c45696b513383261ae0bf
http://link.springer.com/article/10.1186/s12974-018-1204-7

Novel ocellatin peptides mitigate LPS-induced ROS formation and NF-kB activation in microglia and hippocampal neurons

Autor: Joilson Ramos-Jesus, Jand Venes R. Medeiros, André Luis Fernandes Lopes, Marcelo P. Bemquerer, Guilherme Antônio Lopes de Oliveira, Renato Socodato, Nayara A. Sousa, Luan Kelves Miranda de Souza, Eder Alves Barbosa, Thiago S.L. Araújo, Camila C. Portugal, Kerolayne M. Nogueira, Bruno Iles, Peter Eaton, Alexandra Plácido, Andrea Lobo, Alyne Rodrigues de Araújo, João B. Relvas, Yuri D. M. Campelo, José Roberto S. A. Leite, Ana Patrícia de Oliveira, Constança Pais do Amaral

Publikováno v: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice)
Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c936432f2390466bc43188ee5504a1e8
https://hdl.handle.net/10451/47101

Microglia lacking a peroxisomal β-oxidation enzyme chronically alter their inflammatory profile without evoking neuronal and behavioral deficits

Autor: Philip Van Damme, Lien Beckers, Stijn Stroobants, Sander Beel, Ivana Geric, Myriam Baes, Rudi D'Hooge

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Journal of Neuroinflammation

Background Microglia play a central role in most neurological disorders, but the impact of microgliosis on brain environment and clinical functions is not fully understood. Mice lacking multifunctional protein-2 (MFP2), a pivotal enzyme in peroxisoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956cabd117a620008453a8c092f71205
https://doi.org/10.1186/s12974-019-1442-3