Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior

Autor: Joana F. Henriques, Renata L. Alves, Ana Magalhães, Teresa Summavielle, Teresa Canedo, Camila C. Portugal, Cátia M. Silva, João B. Relvas, Renato Socodato, Tiago Almeida, Joana Tedim-Moreira

Alcohol abuse adversely affects the lives of millions of people worldwide. Deficits in synaptic transmission and in microglial function are commonly found in human alcohol abusers and in animal models of alcohol intoxication. Here, we found that a pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5323d1d38dd85484e38fe3dc3daa066
https://hdl.handle.net/10216/140511

A microglial cell model for acyl-CoA oxidase 1 deficiency

Autor: Mustapha Cherkaoui-Malki, Michel Jadot, Stéphane Savary, Quentin Raas, Yannick Hamon, Catherine Gondcaille, Valerio Leoni, Claudio Caccia, Franck Ménétrier, Doriane Trompier, Boubker Nasser, Gérard Lizard, Pierre Andreoletti, Fatima-Ezzahra Saih

Publikováno v: Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids, 2019, 1864 (4), pp.567-576. ⟨10.1016/j.bbalip.2018.10.005⟩
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, Elsevier, 2019, 1864 (4), pp.567-576. ⟨10.1016/j.bbalip.2018.10.005⟩
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2019, 1864 (4), pp.567-576. ⟨10.1016/j.bbalip.2018.10.005⟩

Acyl-CoA oxidase 1 (ACOX1) deficiency is a rare and severe peroxisomal leukodystrophy associated with a very long-chain fatty acid (VLCFA) β–oxidation defect. This neurodegenerative disease lacks relevant cell models to further decipher the pathom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6f3ecebeab89d9110a18d1ae1e300d
https://hal.archives-ouvertes.fr/hal-02359450

Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain

Autor: Martin Wirenfeldt, Mads D. Pedersen, Paul Cumming, Bente Finsen, Michael Meldgaard, Luciano Minuzzi, Carina Slidsborg

Publikováno v: Pedersen, M D, Minuzzi, L, Wirenfeldt, M, Madsen, T M, Slidsborg, C, Cumming, P & Finsen, B 2006, ' Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain ', Eur. J. Neurosci., no. 24, pp. 991-1000 .
Pedersen, M D, Minuzzi, L, Wirenfeldt, M, Meldgaard, M, Slidsborg, C, Cumming, P & Finsen, B 2006, ' Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain ', European Journal of Neuroscience, vol. 24, no. 4, pp. 991-1000 . https://doi.org/10.1111/j.1460-9568.2006.04975.x

Increased binding of the peripheral benzodiazepine binding site (PBBS) ligand [(3)H]PK11195 in the central nervous system of patients suffering from acute and chronic neuropathology has been associated with reactive microgliosis. However, it remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8181f9be688b0e27fc1431571f3bb826
https://doi.org/10.1111/j.1460-9568.2006.04975.x

TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes

Autor: Rey Paglinawan, Adriano Fontana, Ralph Schlapbach, Ursula Malipiero, Walter Reith, Karl Frei

Publikováno v: Glia, Vol. 44, No 3 (2003) pp. 219-231

In experimental autoimmune encephalomyelitis, the acute phase of the disease is produced by T-helper lymphocyte type 1 (TH1), which produces mainly TNFalpha and IFNgamma. Recovery from the disease is mediated by T-helper lymphocyte types 2 and 3 (TH2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0bb8dd4b97c5b7c5b31790ac7c5018e
https://pubmed.ncbi.nlm.nih.gov/14603463

Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination

Autor: Marie-Gabrielle Zurich, Paul Honegger, Antoinette Defaux, Olivier Braissant, Florianne Monnet-Tschudi

Publikováno v: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 6, Iss 1, p 15 (2009)
Journal of Neuroinflammation, vol. 6, pp. 15

Background Brain inflammation plays a central role in numerous brain pathologies, including multiple sclerosis (MS). Microglial cells and astrocytes are the effector cells of neuroinflammation. They can be activated also by agents such as interferon-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bc13768a26d20458c63bb67e3520d1
http://europepmc.org/articles/PMC2687435