Phosphorothioate DNA modification by BREX Type 4 systems in the human gut microbiome.

Autor: Yuan Y; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., DeMott MS; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Center for Environmental Health Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Byrne SR; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Flores K; Department of Microbiology, Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Poyet M; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Institute of Experimental Medicine, Kiel University, Germany.; Global Microbiome Conservancy (https://microbiomeconservancy.org/), Kiel University, Germany., Groussin M; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Institute of Clinical and Molecular Biology, Kiel University, Germany.; Global Microbiome Conservancy (https://microbiomeconservancy.org/), Kiel University, Germany., Microbiome Conservancy G; Global Microbiome Conservancy (https://microbiomeconservancy.org/), Kiel University, Germany.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA., Berdy B; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Comstock L; Department of Microbiology, Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Alm EJ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA.; Singapore-MIT Alliance for Research and Technology, Singapore., Dedon PC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Center for Environmental Health Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Singapore-MIT Alliance for Research and Technology, Singapore.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 03. Date of Electronic Publication: 2024 Jun 03.