Nudix hydrolases with Coenzyme A (CoA) and acyl-CoA pyrophosphatase activities confer growth advantage to Mycobacterium smegmatis

Autor: Shashanka Aroli, Umesh Varshney, Rajagopal Varada, Indu Kapoor

Publikováno v: Microbiology. 165:1219-1232

Nudix hydrolase family proteins hydrolyse toxic by-products of cellular metabolism such as mutagenic nucleoside triphosphates, sugar nucleotides and signalling molecules. We studied the substrate specificities of Nudix hydrolases encoded by rv3672c a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e49ac1babaa2d11f918dc736856c62e
https://doi.org/10.1099/mic.0.000850

Mycobacterial transcript cleavage factor Gre, exhibits chaperone-like activity

Autor: Valakunja Nagaraja, Ramanathan Natesh, Abyson Joseph

Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1867:757-764

Gre factors reactivate stalled elongation complexes by enhancing the intrinsic transcript cleavage activity of RNA polymerase. Previous work by us has shown that unlike in Escherichia coli (E.coli), Mycobacterium tuberculosis Gre factor is essential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb2a300a5f56c89c8d0a42ce2ab417f
https://doi.org/10.1016/j.bbapap.2019.05.008

Glioblastoma vs temozolomide: can the red queen race be won?

Autor: Anjali Arora, Kumaravel Somasundaram

Publikováno v: Cancer Biol Ther

Glioblastoma is the most invasive form of brain tumor. Although temozolomide chemotherapy has been shown to significantly improve survival in patients with GBM, this increase is only trivial. The underlying cause is that many GBMs do not respond to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07e815d113092eddadb5143e237dca0
https://doi.org/10.1080/15384047.2019.1599662

Deregulated AUF1 Assists BMP-EZH2–Mediated Delayed Wound Healing during Candida albicans Infection

Autor: Bharat Bhatt, Riyaz Ahmad Shah, Kithiganahalli Narayanaswamy Balaji, Preeti Yadav, Kasturi Mahadik

Publikováno v: The Journal of Immunology. 201:3617-3629

Tissue repair is a complex process that necessitates an interplay of cellular processes, now known to be dictated by epigenetics. Intriguingly, macrophages are testimony to a large repertoire of evolving functions in this process. We identified a rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4cf9eef444aed22fad1d87cc4cfb56
https://doi.org/10.4049/jimmunol.1800688

Intravenous immunoglobulin mediates anti-inflammatory effects in peripheral blood mononuclear cells by inducing autophagy

Autor: Olivier Benveniste, Varun K. Sharma, Maxime Lecerf, Anupama Karnam, Emmanuel Stephen-Victor, Bharat Bhatt, Fabian Käsermann, Veerupaxagouda Patil, Kithiganahalli Narayanaswamy Balaji, Jagadeesh Bayry, Naresh Rambabu, Srini V. Kaveri, Mrinmoy Das, Laurent Gilardin, Patrick Bruneval

Publikováno v: Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2020, ⟨10.1038/s41419-020-2249-y⟩
Cell Death and Disease, 2020, 11 (1), pp.50. ⟨10.1038/s41419-020-2249-y⟩
Cell Death and Disease, Nature Publishing Group, 2020, 11 (1), pp.50. ⟨10.1038/s41419-020-2249-y⟩
Cell Death and Disease, Vol 11, Iss 1, Pp 1-14 (2020)
Cell Death & Disease

Autophagy plays an important role in the regulation of autoimmune and autoinflammatory responses of the immune cells. Defective autophagy process is associated with various autoimmune and inflammatory diseases. Moreover, in many of these diseases, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5aab3fd104a4e542dd1233719db4d27
https://www.hal.inserm.fr/inserm-02455428