Zobrazeno 1 - 10
of 11
pro vyhledávání: '"MicroRNAs/genetics/metabolism"'
Publikováno v:
Seminars in Liver Disease, Vol. 35, No 1 (2015) pp. 12-25
Seminars in Liver Diseases
Seminars in Liver Diseases
Overweight and obesity, insulin resistance and diabetes, chronic alcoholism, as well as infection by specific genotypes of hepatitis C viruses are all associated with an excessive and chronic ectopic accumulation of fat in the liver (steatosis). If t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06757100dfb60fb9cd1d0a69c02e7d1e
https://doi.org/10.1055/s-0034-1397345
https://doi.org/10.1055/s-0034-1397345
Autor:
Katsushima, K., Natsume, A., Ohka, F., Shinjo, K., Hatanaka, A., Ichimura, N., Sato, S., Takahashi, S., Kimura, Hiroshi, Totoki, Y., Shibata, T., Naito, M., Kim, H. J., Miyata, K., Kataoka, K., Kondo, Y.
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Targeting self-renewal is an important goal in cancer therapy and recent studies have focused on Notch signalling in the maintenance of stemness of glioma stem cells (GSCs). Understanding cancer-specific Notch regulation would improve specificity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4ba4865d3c825af20cfcc6dd8cb7d1
https://doi.org/10.1038/ncomms13616
https://doi.org/10.1038/ncomms13616
Autor:
Bal Bhat, Markus H. Heim, Jiirgen Soutschek, Mirko Trajkovski, Jean Hausser, Akinc Akin, Markus Stoffel, Mihaela Zavolan
Publikováno v:
Nature
Nature, Vol. 474, No 7353 (2011) pp. 649-53
Nature, Vol. 474, No 7353 (2011) pp. 649-53
Defects in insulin signalling are among the most common and earliest defects that predispose an individual to the development of type 2 diabetes. MicroRNAs have been identified as a new class of regulatory molecules that influence many biological fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3299565002fe1a46f72b04bbaedf12a8
Autor:
Audrey Letourneau, Stylianos E. Antonarakis, Samuel Deutsch, Emilie Falconnet, Corinne Gehrig, Christelle Borel, Charles E. Vejnar, Eugenia Migliavacca, Stephen B. Montgomery, Antigone S. Dimas, Maryline Gagnebin, Emmanouil T. Dermitzakis, Yann Dupré, Homa Attar
Publikováno v:
Genome research
Genome Research, Vol. 21, No 1 (2011) pp. 68-73
Genome Research, Vol. 21, No 1 (2011) pp. 68-73
MicroRNAs (miRNAs) are regulatory noncoding RNAs that affect the production of a significant fraction of human mRNAs via post-transcriptional regulation. Interindividual variation of the miRNA expression levels is likely to influence the expression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abb07d25493e6441edd37cf149f095d
Autor:
Tattikota, Sudhir G., Rathjen, Thomas, McAnulty, Sarah J., Wessels, Hans-Hermann, Akerman, Ildem, van de Bunt, Martijn, Hausser, Jean, Esguerra, Jonathan L.S., Musahl, Anne, Pandey, Amit K., You, Xintian, Chen, Wei, Herrera, Pedro L., Johnson, Paul R., O’Carroll, Donal, Eliasson, Lena, Zavolan, Mihaela, Gloyn, Anna L., Ferrer, Jorge, Shalom-Feuerstein, Ruby, Aberdam, Daniel, Poy, Matthew N.
Publikováno v:
Cell Metabolism; 19(1), pp 122-134 (2014)
Cell Metabolism, Vol. 19, No 1 (2014) pp. 122-34
Cell Metabolism
Cell Metabolism, Vol. 19, No 1 (2014) pp. 122-34
Cell Metabolism
Summary Pancreatic β cells adapt to compensate for increased metabolic demand during insulin resistance. Although the microRNA pathway has an essential role in β cell proliferation, the extent of its contribution is unclear. Here, we report that mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2908d9b871cd82288b7562d12c2580c3
http://edoc.mdc-berlin.de/13771/1/13771oa.pdf
http://edoc.mdc-berlin.de/13771/1/13771oa.pdf
Publikováno v:
Nature Cell Biology, Vol. 14, No 12 (2012) pp. 1330-5
Nature Cell Biology
Nature Cell Biology
Brown adipose tissue (BAT) uses the chemical energy of lipids and glucose to produce heat, a function that can be induced by cold exposure or diet. A key regulator of BAT is the gene encoding PR domain containing 16 (Prdm16), whose expression can dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ef22992e9e8952b5d4f73518ffc653
https://pubmed.ncbi.nlm.nih.gov/23196844
https://pubmed.ncbi.nlm.nih.gov/23196844
Autor:
Leopold Parts, Åsa K Hedman, Sarah Keildson, Andrew J Knights, Cei Abreu-Goodger, Martijn van de Bunt, José Afonso Guerra-Assunção, Nenad Bartonicek, Stijn van Dongen, Reedik Mägi, James Nisbet, Amy Barrett, Mattias Rantalainen, Alexandra C Nica, Michael A Quail, Kerrin S Small, Daniel Glass, Anton J Enright, John Winn, MuTHER Consortium, Panos Deloukas, Emmanouil T Dermitzakis, Mark I McCarthy, Timothy D Spector, Richard Durbin, Cecilia M Lindgren
Publikováno v:
PLoS Genetics
PLOS Genetics, Vol. 8, No 5 (2012) P. e1002704
PLoS Genetics, Vol 8, Iss 5, p e1002704 (2012)
PLOS Genetics, Vol. 8, No 5 (2012) P. e1002704
PLoS Genetics, Vol 8, Iss 5, p e1002704 (2012)
Small RNAs are functional molecules that modulate mRNA transcripts and have been implicated in the aetiology of several common diseases. However, little is known about the extent of their variability within the human population. Here, we characterise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2682aba05c2daf649010d4225f1e5477
https://pubmed.ncbi.nlm.nih.gov/22589741
https://pubmed.ncbi.nlm.nih.gov/22589741
Autor:
Charles E. Vejnar, Marguerite Neerman-Arbez, Charles Pineau, Antoine Rolland, Olivier Schaad, Serge Nef, Marilena D. Papaioannou, Florian Guillou, Alexandre Fort, Mélanie Lagarrigue, Patrick Descombes, Evgeny M. Zdobnov, Florence Aubry, Françoise Kühne
Publikováno v:
Molecular and Cellular Proteomics
Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2011, 10 (4), pp.M900587MCP200. ⟨10.1074/mcp.M900587-MCP200⟩
Molecular & cellular proteomics : MCP
Molecular and Cellular Proteomics, 2011, 10 (4), pp.M900587MCP200. ⟨10.1074/mcp.M900587-MCP200⟩
Molecular and Cellular Proteomics, Vol. 10, No 4 (2011) P. M900587MCP200
Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2011, 10 (4), pp.M900587MCP200. ⟨10.1074/mcp.M900587-MCP200⟩
Molecular & cellular proteomics : MCP
Molecular and Cellular Proteomics, 2011, 10 (4), pp.M900587MCP200. ⟨10.1074/mcp.M900587-MCP200⟩
Molecular and Cellular Proteomics, Vol. 10, No 4 (2011) P. M900587MCP200
International audience; Sertoli cells (SCs) are the central, essential coordinators of spermatogenesis, without which germ cell development cannot occur. We previously showed that Dicer, an RNaseIII endonuclease required for microRNA (miRNA) biogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01615c777d2f2e9f61d829e9f629873
https://hal.archives-ouvertes.fr/hal-00659542
https://hal.archives-ouvertes.fr/hal-00659542
Publikováno v:
Gunaratne, P H, Creighton, C J, Watson, M & Tennakoon, J B 2010, ' Large-scale integration of MicroRNA and gene expression data for identification of enriched microRNA-mRNA associations in biological systems ', Methods in Molecular Biology, vol. 667, pp. 297-315 . https://doi.org/10.1007/978-1-60761-811-9_20
The discovery of microRNAs (miRNAs) revealed a hidden layer of gene regulation that is able to integrate multiple genes into biologically meaningful networks. A number of computational prediction programs have been developed to identify putative miRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3094::845dbff4ff81aba8703d50e7873b4ab3
https://www.pure.ed.ac.uk/ws/files/8204346/Gunaratne_et_al_2010.pdf
https://www.pure.ed.ac.uk/ws/files/8204346/Gunaratne_et_al_2010.pdf
Autor:
Didier Picard, Deo Prakash Pandey
Publikováno v:
Molecular and Cellular Biology, Vol. 29, No 13 (2009) pp. 3783-90
Estrogen receptor alpha (ER alpha) is a ligand-regulated transcription factor with a broad range of physiological functions and one of the most important classifiers in breast cancer. MicroRNAs (miRNAs) are small noncoding RNAs that have emerged as i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf769baddb737ce0d6ec566137aff10
https://archive-ouverte.unige.ch/unige:4469
https://archive-ouverte.unige.ch/unige:4469