Výsledky vyhledávání - "MicroRNAs/genetics"

Akademický článek

Epigenetic markers in head and neck cancer: special view on HPV-associated oropharyngeal cancer

Autor: Nina Milutin Gašperov, Ivan Sabol, Vjekoslav Tomaić, Magdalena Garce

Publikováno v: Liječnički vjesnik, Vol 144, Iss 3-4, Pp 96-105 (2022)

Despite continuous efforts to identify molecular markers for the early detection of head and neck cancer (HNC), and improved therapy, the overall survival and prognosis of HNC patients still remain poor. Scientific evidences suggest that HPV-associat

Externí odkaz: https://doaj.org/article/37a171f41672496f8be0c8707e93d154

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Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145

Autor: Wade, Henry, Pan, Kaichao, Duan, Qihua, Kaluzny, Szczepan, Pandey, Ekta, Fatumoju, Linda, Saraswathi, Viswanathan, Wu, Rongxue, Harris, Edward N, Su, Qiaozhu

Publikováno v: Wade, H, Pan, K, Duan, Q, Kaluzny, S, Pandey, E, Fatumoju, L, Saraswathi, V, Wu, R, Harris, E N & Su, Q 2023, ' Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145 ', Journal of Biomedical Science, vol. 30, 38 . https://doi.org/10.1186/s12929-023-00935-1

BackgroundThe intestinal epithelial barrier is the interface for interaction between gut microbiota and host metabolic systems. Akkermansia muciniphila (A. muciniphila) is a key player in the colonic microbiota that resides in the mucus layer, whose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2607::d98c578ced73a224b243fb2d3069fbdc
https://pure.qub.ac.uk/en/publications/615e67bc-9c9f-4245-81d9-64c50b471667

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Molecular mechanisms of postoperative atrial fibrillation in patients with obstructive sleep apnea

Autor: Raquel López‐Gálvez, José Miguel Rivera‐Caravaca, Darío Mandaglio‐Collados, Esteban Orenes‐Piñero, Álvaro Lahoz, Diana Hernández‐Romero, Carlos M. Martínez, Marina Carpes, José María Arribas, Sergio Cánovas, Gregory Y. H. Lip, Francisco Marín

Publikováno v: López-Gálvez, R, Rivera-Caravaca, J M, Mandaglio-Collados, D, Orenes-Piñero, E, Lahoz, Á, Hernández-Romero, D, Martínez, C M, Carpes, M, Arribas, J M, Cánovas, S, Lip, G Y H & Marín, F 2023, ' Molecular mechanisms of postoperative atrial fibrillation in patients with obstructive sleep apnea ', The FASEB Journal, vol. 37, no. 6, e22941 . https://doi.org/10.1096/fj.202201965RR

Obstructive sleep apnea (OSA) promotes atrial remodeling and fibrosis, providing a substrate for atrial fibrillation (AF). Herein, we investigate the pathophysiological mechanisms of AF in association with OSA in a cohort of cardiac surgery patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471ccb1cc7b0e4c66e6d9b7650c99e64
https://vbn.aau.dk/da/publications/ba6753ea-0013-403f-9d91-1d09329eb950

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Sjögren’s syndrome: novel insights from proteomics and miRNA expression analysis

Autor: Sarah Kamounah, Maria Lynn Sembler-Møller, Claus Henrik Nielsen, Anne Marie Lynge Pedersen

Publikováno v: Kamounah, S, Sembler-Møller, M L, Nielsen, C H & Pedersen, A M L 2023, ' Sjögren's syndrome : novel insights from proteomics and miRNA expression analysis ', Frontiers in Immunology, vol. 14, 1183195 . https://doi.org/10.3389/fimmu.2023.1183195
Kamounah, S, Sembler-Møller, M L, Nielsen, C H & Pedersen, A M L 2023, ' Sjögren’s syndrome : novel insights from proteomics and miRNA expression analysis ', Frontiers in Immunology, vol. 14, 1183195 . https://doi.org/10.3389/fimmu.2023.1183195

IntroductionSjögren’s syndrome (SS) is a systemic autoimmune disease, which affects the exocrine glands leading to glandular dysfunction and, particularly, symptoms of oral and ocular dryness. The aetiology of SS remains unclear, and the disease l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d68d0a0b7d887e569857c6a5a3696cb

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A conserved SNP variation in the pre-miR396c flanking region in Oryza sativa indica landraces correlates with mature miRNA abundance

Autor: Deepa Jaganathan, Raja Rajakani, Dadakhalandar Doddamani, Divya Saravanan, Shalini Pulipati, Vivek Hari Sundar G, Gothandapani Sellamuthu, Shilpha Jayabalan, Kumkum Kumari, Pavithra Parthasarathy, Punitha S., Sivaprakash Ramalingam, Padubidri V. Shivaprasad, Gayatri Venkataraman

Publikováno v: Jaganathan, D, Rajakani, R, Doddamani, D, Saravanan, D, Pulipati, S, Hari Sundar G, V, Sellamuthu, G, Jayabalan, S, Kumari, K, Parthasarathy, P, S, P, Ramalingam, S, Shivaprasad, P V & Venkataraman, G 2023, ' A conserved SNP variation in the pre-miR396c flanking region in Oryza sativa indica landraces correlates with mature miRNA abundance ', Scientific Reports, vol. 13, no. 1, 2195, pp. 1-16 . https://doi.org/10.1038/s41598-023-28836-1

Plant precursor miRNAs (pre-miRNA) have conserved evolutionary footprints that correlate with mode of miRNA biogenesis. In plants, base to loop and loop to base modes of biogenesis have been reported. Conserved structural element(s) in pre-miRNA play

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bade1316cec01a52086a5e9b5737a6d
https://hdl.handle.net/20.500.11820/f2112633-d452-465f-8bae-6324377f1078

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Circulating levels and the bioactivity of miR-30b increase during pubertal progression in boys

Autor: Nina Mørup, Rytis Stakaitis, Ailsa Maria Main, Ieva Golubickaite, Casper P. Hagen, Anders Juul, Kristian Almstrup

Publikováno v: Mørup, N, Stakaitis, R, Main, A M, Golubickaite, I, Hagen, C P, Juul, A & Almstrup, K 2023, ' Circulating levels and the bioactivity of miR-30b increase during pubertal progression in boys ', Frontiers in Endocrinology, vol. 14, pp. 1120115 . https://doi.org/10.3389/fendo.2023.1120115

BackgroundPuberty marks the transition from childhood to adulthood and is initiated by activation of a pulsatile GnRH secretion from the hypothalamus. MKRN3 functions as a pre-pubertal break on the GnRH pulse generator and hypothalamic expression and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0e129096736b802c9d5afcf47d2a7a
https://curis.ku.dk/ws/files/336076267/fendo_14_1120115.pdf

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WNT5A, β‑catenin and SUFU expression patterns, and the significance of microRNA deregulation in placentas with intrauterine growth restriction

Autor: Ida Sola, Valentina Karin‑Kujundzic, Frane Paic, Lada Lijovic, Mislav Glibo, Nikola Serman, Tihana Duic, Anita Skrtic, Krunoslav Kuna, Semir Vranic, Ljiljana Serman

Placental insufficiency is a common cause of intrauterine growth restriction (IUGR). It affects ~10% of pregnancies and increases fetal and neonatal morbidity and mortality. Although Wnt and Hh pathways are crucial for embryonic development and place

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198042dc83dc8282d4c80692ceb07f04
https://doi.org/10.3892/mmr.2022.12914

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Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa

Autor: Shenghan Su, Qingrui Zhao, Lingfeng Dan, Yuqing Lin, Xuebei Li, Yunjin Zhang, Chunxiao Yang, Yimeng Dong, Xiaohan Li, Romano Regazzi, Changhao Sun, Xia Chu, Huimin Lu

Publikováno v: Endocrinology and metabolism, vol. 37, no. 6, pp. 901-917

Background: Chronic exposure to elevated levels of saturated fatty acids results in pancreatic β-cell senescence. However, targets and effective agents for preventing stearic acid-induced β-cell senescence are still lacking. Although melatonin admi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d41efba2b802a9d30990fdc1cb62e7
https://serval.unil.ch/resource/serval:BIB_75304B1DDDAE.P001/REF.pdf

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NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia

Autor: Mouhamed Alsaqati, Brittany A. Davis, Jamie Wood, Megan M. Jones, Lora Jones, Aishah Westwood, Olena Petter, Anthony R. Isles, David Linden, Marianne Van den Bree, Michael Owen, Jeremy Hall, Adrian J. Harwood

Publikováno v: Translational Psychiatry, 12(1):438. Nature Publishing Group

Genetic evidence indicates disrupted epigenetic regulation as a major risk factor for psychiatric disorders, but the molecular mechanisms that drive this association remain to be determined. EHMT1 is an epigenetic repressor that is causal for Kleefst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19c8d69168f0393e7305de2dc7bbf36
https://doi.org/10.1038/s41398-022-02199-z

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Global and precise identification of functional miRNA targets in mESCs by integrative analysis

Autor: Moritz Schaefer, Amena Nabih, Daniel Spies, Victoria Hermes, Maxime Bodak, Harry Wischnewski, Patrick Stalder, Richard Patryk Ngondo, Luz Angelica Liechti, Tatjana Sajic, Ruedi Aebersold, David Gatfield, Constance Ciaudo

Publikováno v: EMBO Reports, 23 (9)
EMBO reports, vol. 23, no. 9, pp. e54762

MicroRNA (miRNA) loaded Argonaute (AGO) complexes regulate gene expression via direct base pairing with their mRNA targets. Previous works suggest that up to 60% of mammalian transcripts might be subject to miRNA-mediated regulation, but it remains l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac6c06db06c71b93a726d1891fff63a
https://hdl.handle.net/20.500.11850/561780

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