Výsledky vyhledávání - "MicroRNA 34a"

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DNA methyltransferase 3 beta mediates the methylation of the microRNA-34a promoter and enhances chondrocyte viability in osteoarthritis

Autor: Tiantong Xu, Yong Zhao, Shouliang Xiong

Publikováno v: Bioengineered, Vol 12, Iss 2, Pp 11138-11155 (2021)
Bioengineered
article-version (VoR) Version of Record

Osteoarthritis (OA) is characterized by destruction of articular cartilage with an imbalance between synthesis and degradation of extracellular matrix (ECM). In the current study, we explored the role of microRNA-34a (miR-34a) and the behind epigenet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83b87bc1fd2d0ffadfba677c3fdc8cf
https://doaj.org/article/eb8b0633d16c4208b9da4a29187208f0

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Mesenchymal Stem Cell-derived Extracellular Vesicles Transmitting MicroRNA-34a-5p Suppress Tumorigenesis of Colorectal Cancer Through c-MYC/DNMT3a/PTEN Axis

Autor: Kunsong Huang, Huanrong Lin, Jiangning Zhao

Publikováno v: Molecular Neurobiology

Mesenchymal stem cell–derived extracellular vesicles (MSC-EV) can transport microRNAs (miRNAs) into colorectal cancer (CRC) cells, thus to inhibit the malignant phenotype of cancer cells. Whether MSC-EV could deliver miR-34a-5p to suppress CRC deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea45e2f8b1a2a4151f751140d5dfbd3a
https://doi.org/10.1007/s12035-021-02431-9

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Mutate-and-chemical-shift-fingerprint (MCSF) to characterize excited states in RNA using NMR spectroscopy

Autor: Lorenzo Baronti, Judith Schlagnitweit, Katja Petzold, Hampus Karlsson, Noah Hopkins, Magdalena Riad

Publikováno v: Nature Protocols. 16:5146-5170

It is important to understand the dynamics and higher energy structures of RNA, called excited states, to achieve better understanding of RNA function. R1ρ relaxation dispersion NMR spectroscopy (RD) determines chemical shift differences between the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa02d8bb1a898c07126a1f28daaa96b
https://doi.org/10.1038/s41596-021-00606-1

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MicroRNA-34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis

Publikováno v: Neuropathology and Applied Neurobiology
Neuropathology and Applied Neurobiology, 47, 796-811. Wiley-Blackwell
Neuropathology and Applied Neurobiology, 47(6), 796-811. Wiley-Blackwell
Neuropathology and applied neurobiology, 47(6), 796-811. Wiley-Blackwell

Aims Tuberous sclerosis complex (TSC) is a genetic disorder associated with dysregulation of the mechanistic target of rapamycin complex 1 (mTORC1) signalling pathway. Neurodevelopmental disorders, frequently present in TSC, are linked to cortical tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb0f7241374fa2ea6880a3964dbd171
https://dare.uva.nl/personal/pure/en/publications/microrna34a-activation-in-tuberous-sclerosis-complex-during-early-brain-development-may-lead-to-impaired-corticogenesis(54e41bc9-19fa-4850-90b0-8be834807835).html

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MicroRNA-34a Alleviates Gemcitabine Resistance in Pancreatic Cancer by Repression of Cancer Stem Cell Renewal

Autor: Ge Gao, Jianzhou Liu, Ning Li, Yue Pan, Xufeng Tao, Qing Chen, Kun Li, Junchao Guo, Gary Guishan Xiao, Yongxin Zhao, Vay Liang W. Go

Publikováno v: Pancreas. 50:1260-1266

OBJECTIVES This study aimed to enhance the sensitivity of pancreatic ductal adenocarcinoma cells by microRNA-34a (miR-34a)-mediated targeting of Notch 1. METHODS Cell viability was determined by using an MTT (3-(4,5)-dimethylthiahiazo(-2)-3,5-dipheny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc44b31821a21c258b90fdd84d36e314
https://doi.org/10.1097/mpa.0000000000001920

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Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis

Publikováno v: Atherosclerosis. 327:49-58

Preclinical data suggest that the ageing-induced miR-34a regulates vascular senescence. Herein we sought to assess whether the miR-34 family members miR-34a, miR-34b and miR-34c are involved in human arterial disease.Expression levels of miR-34a/b/c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c100b8e3f912ef78bf227ac9acc1e6e
https://doi.org/10.1016/j.atherosclerosis.2021.05.005

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Curcumin-Alleviated Osteoarthritic Progression in Rats Fed a High-Fat Diet by Inhibiting Apoptosis and Activating Autophagy via Modulation of MicroRNA-34a

Autor: Xin Dong, Jiayu Yao, Xiaotong Liu, Li Liu, Hailun Gu, Yingxu Sun

Publikováno v: Journal of Inflammation Research

Jiayu Yao,1 Xiaotong Liu,1 Yingxu Sun,1 Xin Dong,1 Li Liu,1 Hailun Gu2 1Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, 110122, People’s Republic of China; 2Department of Orthopedics, Shengjing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e909a9598246115528e311089c653374
http://europepmc.org/articles/PMC8179815

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MicroRNA-34a Promotes EMT and Liver Fibrosis in Primary Biliary Cholangitis by Regulating TGF-β1/smad Pathway

Autor: Jing Wang, Lan He, Fengchun Zhang, Ying Pan

Publikováno v: Journal of Immunology Research, Vol 2021 (2021)

Background and Aims. Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease. We found microRNA-34a (miR-34a), as the downstream gene of p53, was overexpressed in some of fibrogenic diseases. In this study, we sought to explore w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8dfcd49382954fe566e67ea55868ad1
https://doi.org/10.1155/2021/6890423

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