Zobrazeno 1 - 10
of 372
pro vyhledávání: '"MicroED"'
Autor:
Laurens Bourda, Subhrajyoti Bhandary, Sho Ito, Christian R. Göb, Pascal Van Der Voort, Kristof Van Hecke
Publikováno v:
IUCrJ, Vol 11, Iss 4, Pp 510-518 (2024)
Although COF-300 is often used as an example to study the synthesis and structure of (3D) covalent organic frameworks (COFs), knowledge of the underlying synthetic processes is still fragmented. Here, an optimized synthetic procedure based on a combi
Externí odkaz:
https://doaj.org/article/bf1ba850e546468a82883d5c48b3540c
Publikováno v:
IUCrJ, Vol 11, Iss 4, Pp 476-485 (2024)
A series of events underscoring the significant advancements in micro-crystallization and in vivo crystallography were held during the 26th IUCr Congress in Melbourne, positioning microcrystallography as a pivotal field within structural biology. Thr
Externí odkaz:
https://doaj.org/article/8e0bff89071c44c4a6c065b6029e1d97
Publikováno v:
Journal of Structural Biology: X, Vol 10, Iss , Pp 100107- (2024)
Clostripain secreted from Clostridium histolyticum is the founding member of the C11 family of Clan CD cysteine peptidases, which is an important group of peptidases secreted by numerous bacteria. Clostripain is an arginine-specific endopeptidase. Be
Externí odkaz:
https://doaj.org/article/f8ebe8552c8544a8b6e77f0a351d2084
Publikováno v:
Journal of Structural Biology: X, Vol 9, Iss , Pp 100102- (2024)
Microcrystal electron diffraction (MicroED) has emerged as a powerful technique for unraveling molecular structures from microcrystals too small for X-ray diffraction. However, a significant hurdle arises with plate-like crystals that consistently or
Externí odkaz:
https://doaj.org/article/8535d678483245299ce21056f86413f3
Publikováno v:
Advanced Science, Vol 11, Iss 6, Pp n/a-n/a (2024)
Abstract Meclizine (Antivert, Bonine) is a first‐generation H1 antihistamine used in the treatment of motion sickness and vertigo. Despite its wide medical use for over 70 years, its crystal structure and the details of protein‐drug interactions
Externí odkaz:
https://doaj.org/article/8fbba48bbc7a4c1db24d2dd2d1b546e9
Publikováno v:
IUCrJ, Vol 10, Iss 4, Pp 430-436 (2023)
In this work, a novel crystal growth method termed suspended drop crystallization has been developed. Unlike traditional methods, this technique involves mixing protein and precipitant directly on an electron microscopy grid without any additional su
Externí odkaz:
https://doaj.org/article/68984af222c643ccbbc98efd18555d28
Publikováno v:
Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)
Abstract Mirabegron, commonly known as “Myrbetriq”, has been widely prescribed as a medicine for overactive bladder syndrome for over a decade. However, the structure of the drug and what conformational changes it may undergo upon binding its rec
Externí odkaz:
https://doaj.org/article/c75353de462c45098c6b1b0bf0965b28
Autor:
Mohammed Hawash, Derar Al-Smadi, Anil Kumar, Barbara Olech, Paulina Maria Dominiak, Nidal Jaradat, Sarah Antari, Sarah Mohammed, Ala’a Nasasrh, Murad Abualhasan, Ahmed Musa, Shorooq Suboh, İrfan Çapan, Mohammad Qneibi, Hiba Natsheh
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1486 (2023)
In this study, we synthesized benzodioxol carboxamide derivatives and investigated their antidiabetic potential. The synthesized compounds (Ia-Ic and IIa-IId) underwent characterization via HRMS, 1H-, 13CAPT-NMR, and MicroED. Their efficacy against
Externí odkaz:
https://doaj.org/article/9c58b669f4324401ac695c2786f37d07
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