Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Mickie Bhatia"'
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 11, Pp 1180-1191 (2019)
Abstract Chemotherapy‐induced peripheral neuropathy (PN) is a disorder damaging the peripheral nervous system (PNS) and represents one of the most common side effects of chemotherapy, negatively impacting the quality of life of patients to the exte
Externí odkaz:
https://doaj.org/article/3764edd4f1da44579dfe797072a729e3
Autor:
Deanna P. Porras, Jennifer C. Reid, Borko Tanasijevic, Diana Golubeva, Allison L. Boyd, Mickie Bhatia
Publikováno v:
Cells, Vol 11, Iss 12, p 1915 (2022)
The generation of human hematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) represents a major goal in regenerative medicine and is believed would follow principles of early development. HSCs arise from a type of endothelial cel
Externí odkaz:
https://doaj.org/article/19f4c3de54d34c008ebcff23688ec3d4
Autor:
Luca Orlando, Borko Tanasijevic, Mio Nakanishi, Jennifer C. Reid, Juan L. García-Rodríguez, Kapil Dev Chauhan, Deanna P. Porras, Lili Aslostovar, Justin D. Lu, Zoya Shapovalova, Ryan R. Mitchell, Allison L. Boyd, Mickie Bhatia
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108818- (2021)
Summary: Histone variants (HVs) are a subfamily of epigenetic regulators implicated in embryonic development, but their role in human stem cell fate remains unclear. Here, we reveal that the phosphorylation state of the HV H2A.X (γH2A.X) regulates s
Externí odkaz:
https://doaj.org/article/4557e53b20234f89a0c512ca3d13ed30
Autor:
Lili Aslostovar, Allison L. Boyd, Mohammed Almakadi, Tony J. Collins, Darryl P. Leong, Rommel G. Tirona, Richard B. Kim, Jim A. Julian, Anargyros Xenocostas, Brian Leber, Mark N. Levine, Ronan Foley, Mickie Bhatia
Publikováno v:
Blood Advances, Vol 2, Iss 15, Pp 1935-1945 (2018)
Abstract: We completed a phase 1 dose-escalation trial to evaluate the safety of a dopamine receptor D2 (DRD2) antagonist thioridazine (TDZ), in combination with cytarabine. Thirteen patients 55 years and older with relapsed or refractory acute myelo
Externí odkaz:
https://doaj.org/article/65462c7955b0444b8aa80b9a26bdee79
Autor:
Jennifer C. Reid, Borko Tanasijevic, Diana Golubeva, Allison L. Boyd, Deanna P. Porras, Tony J. Collins, Mickie Bhatia
Publikováno v:
Stem Cell Reports, Vol 10, Iss 5, Pp 1625-1641 (2018)
Summary: Human pluripotent stem cells (hPSCs) generate hematopoietic progenitor cells (HPCs) but fail to engraft xenograft models used to detect adult/somatic hematopoietic stem cells (HSCs) from donors. Recent progress to derive hPSC-derived HSCs ha
Externí odkaz:
https://doaj.org/article/ccabb1b5765542a4a5b34f9e544c110d
Autor:
Jong-Hee Lee, Sarah Laronde, Tony J. Collins, Zoya Shapovalova, Borko Tanasijevic, Jamie D. McNicol, Aline Fiebig-Comyn, Yannick D. Benoit, Jung Bok Lee, Ryan R. Mitchell, Mickie Bhatia
Publikováno v:
Cell Reports, Vol 19, Iss 1, Pp 20-35 (2017)
Human pluripotent stem cells (hPSCs) have been reported in naive and primed states. However, the ability to generate mature cell types remains the imperative property for utility of hPSCs. Here, we reveal that the naive state enhances self-renewal wh
Externí odkaz:
https://doaj.org/article/632c81e24b1a4140a186435928fb0d4b
Autor:
Kyle R. Salci, Jung Bok Lee, Ryan R. Mitchell, Luca Orlando, Aline Fiebig-Comyn, Zoya Shapovalova, Mickie Bhatia
Publikováno v:
Stem Cell Research, Vol 15, Iss 1, Pp 221-230 (2015)
The combination of OCT4 expression and short-term exposure to reprogramming media induces a state of transcriptional plasticity in human fibroblasts, capable of responding to changes in the extracellular environment that facilitate direct cell fate c
Externí odkaz:
https://doaj.org/article/d5cbb69d81844058a598e4dea421af9c
Autor:
Jong-Hee Lee, Ryan R. Mitchell, Jamie D. McNicol, Zoya Shapovalova, Sarah Laronde, Borko Tanasijevic, Chloe Milsom, Fanny Casado, Aline Fiebig-Comyn, Tony J. Collins, Karun K. Singh, Mickie Bhatia
Publikováno v:
Cell Reports, Vol 11, Iss 9, Pp 1367-1376 (2015)
The clinical applicability of direct cell fate conversion depends on obtaining tissue from patients that is easy to harvest, store, and manipulate for reprogramming. Here, we generate induced neural progenitor cells (iNPCs) from neonatal and adult pe
Externí odkaz:
https://doaj.org/article/b11aa922158d4166b81be9280ad2f0aa
Autor:
Kyle R. Salci, Jung Bok Lee, Ryan R. Mitchell, Luca Orlando, Aline Fiebig-Comyn, Zoya Shapovalova, Mickie Bhatia
Publikováno v:
Stem Cell Research, Vol 15, Iss 1, Pp 240-242 (2015)
The combination of OCT4 expression and short-term exposure to reprogramming media induces a state of transcriptional plasticity in human fibroblasts, capable of responding to changes in the extracellular environment. Here we provide characterization
Externí odkaz:
https://doaj.org/article/80384ffe987c4a9b9202a0b4b2f421c7
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e8065 (2009)
Cancer and normal stem cells (SCs) share proliferative properties of self-renewal and expression of key transcription factors (TFs). Despite similar TF identities, the functional role of specific TFs responsible for retaining SC state has yet to be e
Externí odkaz:
https://doaj.org/article/42c0f1fd35bd4a2d955f027363378259