Výsledky vyhledávání - "Mickey Kertesz"

Plasma Microbial Cell-free DNA Next-generation Sequencing in the Diagnosis and Management of Febrile Neutropenia

Autor: Steven Coutre, Simona Zompi, David K. Hong, Paul L. Bollyky, Lily Blair, Kiran Gajurel, Bruno C. Medeiros, Jill N. Anderson, Romielle Aquino, Esther Benamu, Hon Seng, Carlos A. Gomez, Stan Deresinski, Mickey Kertesz, Timothy A. Blauwkamp, Tullia Lieb, Desiree Hollemon, Jose G. Montoya

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 74, iss 9

Background Standard testing fails to identify a pathogen in most patients with febrile neutropenia (FN). We evaluated the ability of the Karius microbial cell-free DNA sequencing test (KT) to identify infectious etiologies of FN and its impact on ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88d66249eecf84679a03387cc6d48a8
https://pubmed.ncbi.nlm.nih.gov/33870419

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Liquid biopsy for infectious diseases: Sequencing of cell-free plasma to detect pathogen DNA in patients with invasive fungal disease

Autor: Cynthia Truong, Timothy A. Blauwkamp, Niaz Banaei, David K. Hong, Sivan Bercovici, Mickey Kertesz

Diagnosis of life-threatening deep-seated infections currently requires invasive sampling of the infected tissue to provide a microbiologic diagnosis. These procedures can lead to high morbidity in patients and add to healthcare costs. Here we descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0602499b35eb8cba8322c70684ace3fb

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Performance of the Karius Plasma Next Generation Sequencing Test in Determining the Etiologic Diagnosis of Febrile Neutropenia: Results from a Pilot Study

Autor: Jose G. Montoya, Mickey Kertesz, Jill N. Anderson, Bruno C. Medeiros, Kiran Gajurel, Desiree Hollemon, Paul L. Bollyky, Stan Deresinski, Heather D. Ishak, David K. Hong, Esther Benamu, Timothy A Blawkamp, Steven Coutre, Hon Seng

Publikováno v: Open Forum Infectious Diseases

Background Blood cultures (BC) fail to detect a pathogen in most patients with neutropenic fever (NF). We examined the performance of the Karius next generation sequencing plasma test (plasma NGS) compared with that of BC in chemotherapy-induced NF.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2094d4a8a598264d1b98a04cba7ddcd4
https://doi.org/10.1093/ofid/ofx163.1614

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The SEP-SEQ Trial: Clinical Validation of the Karius Plasma Next-Generation Sequencing Test for Pathogen Detection in Sepsis

Autor: Rosen Mann, Timothy A. Blauwkamp, Hon Seng, Carine Ho, Simone A. Thair, Mickey Kertesz, Desiree Hollemon, David K. Hong, James V. Quinn, Samuel Yang

Publikováno v: Open Forum Infectious Diseases

Background Sepsis is a leading cause of death and can be caused by a wide range of potential pathogens. In up to 40% of cases, a causative pathogen is never identified. There is a need for improved diagnostic tests that can accurately identify the br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9409130c62795d806a9cc481de2c7c3b
https://doi.org/10.1093/ofid/ofx180.004

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The DISCOVER Trial: Application of the Karius Plasma Next-Generation Sequencing Test for Pathogen Detection in Stem-Cell Transplant Patients

Autor: Tim Blauwkamp, Monica Fung, Mickey Kertesz, Hon Seng, Peter Chin-Hong, Estelle L. Dolan, Kathy Wong, Desiree Hollemon, Aaron C Logan, David S. Hong, Jamie Eng

Publikováno v: Open Forum Infectious Diseases

Background The diagnosis of infections in stem-cell transplant (SCT) patients is challenging. There is a need for improved diagnostics that can quickly and accurately detect a broad range of viruses, bacteria, and fungi that can infect these patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a644386781011f5666a20df7bb0aded
https://doi.org/10.1093/ofid/ofx163.1623

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Direct Detection and Quantification of Bacterial Cell-free DNA in Patients with Bloodstream Infection (BSI) Using the Karius Plasma Next Generation Sequencing (NGS) Test

Autor: David K. Hong, Jonathan Hill-Rorie, Hon Seng, Felicia Ruffin, Tim Blauwkamp, Lisa Wanda, Vance G. Fowler, Mickey Kertesz, Desiree Hollemon

Publikováno v: Open Forum Infectious Diseases

Background Blood cultures can have low sensitivity if a patient is pretreated with antibiotics. A molecular diagnostic for bloodstream infection (BSI) that can also quantitate pathogen DNA could be a useful tool in detecting and monitoring culture-ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f495fbe51607c7580b6c5c10d78a2319
https://doi.org/10.1093/ofid/ofx163.1613

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