MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways

Autor: Shoji F. Kenji, Keerthi Kurma, Brigitte Collet, Christelle Oblet, Laure Debure, Carmelo Di Primo, Laëtitia Minder, Franck Vérité, Yannic Danger, Mickael Jean, Aubin Penna, Nicolas Levoin, Patrick Legembre

Publikováno v: Cell Death and Disease, Vol 13, Iss 10, Pp 1-11 (2022)

Abstract CD95 is a death receptor that can promote oncogenesis through molecular mechanisms that are not fully elucidated. Although the mature CD95 membrane receptor is considered to start with the arginine at position 17 after elimination of the sig

Externí odkaz: https://doaj.org/article/48a077bb6c494189aee69ecb73c0915b

Newborn infant parasympathetic evaluation for the assessment of analgosedation adequacy in infants treated by mechanical ventilation – a multicenter pilot study

Autor: Wojciech Walas, Ewelina Malinowska, Zenon P. Halaba, Tomasz Szczapa, Julita Latka-Grot, Magdalena Rutkowska, Agata Kubiaczyk, Monika Wrońska, Andrzej Piotrowski, Michał Skrzypek, Mickael Jean-Noel, Iwona Maroszyńska

Publikováno v: Archives of Medical Science, Vol 17, Iss 6, Pp 1651-1656 (2021)

Introduction Adequate analgosedation is important in infants treated in pediatric/neonatal intensive care units (P/NICUs), because both too deep and insufficient analgosedation is disadvantageous. To assess the severity of pain, several behavioral an

Externí odkaz: https://doaj.org/article/3e30af09ef354dafaeff89612944dc99

CD95 Structure, Aggregation and Cell Signaling

Autor: Nicolas Levoin, Mickael Jean, Patrick Legembre

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

CD95 is a pre-ligand-associated transmembrane (TM) receptor. The interaction with its ligand CD95L brings to a next level its aggregation and triggers different signaling pathways, leading to cell motility, differentiation or cell death. This diversi

Externí odkaz: https://doaj.org/article/3776074b1d384be3a5054b40252c84e0

Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target?

Autor: Patrick Blanco, Patrick Legembre, Keerthi Kurma, Andrea Boizard-Moracchini, Mickael Jean, Pierre Vacher, Gaël Galli

Publikováno v: Biochimica et Biophysica Acta (BBA)-Reviews on Cancer
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2021, 1876 (2), pp.188596. ⟨10.1016/j.bbcan.2021.188596⟩
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, Elsevier, 2021, 1876 (2), pp.188596. ⟨10.1016/j.bbcan.2021.188596⟩

International audience; Although CD95L (also known as FasL) is still predominantly considered as a death ligand that induces apoptosis in infected and transformed cells, substantial evidence indicate that it can also trigger non-apoptotic signaling p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ac9316db4c0eea989336cf1297c5b6
https://pubmed.ncbi.nlm.nih.gov/34324950

Ex vivo potential of a quinoline-derivative nail lacquer as a new alternative for dermatophytic onychomycosis treatment

Autor: Marilene Henning Vainstein, Pierre van de Weghe, Denise Diedrich, Simone Jacobus Berlitz, Alexandre Meneghello Fuentefria, Simone Cristina Baggio Gnoatto, Bruna Pippi, Mickael Jean, Diego Defferrari, Gabriella da Rosa Monte Machado, Irene Clemes Külkamp-Guerreiro, William Lopes, Saulo Fernandes de Andrade

Publikováno v: Journal of Medical Microbiology
Journal of Medical Microbiology, 2021, 70 (3), ⟨10.1099/jmm.0.001314⟩
Journal of Medical Microbiology, Society for General Microbiology, 2021, 70 (3), ⟨10.1099/jmm.0.001314⟩

Introduction. Onychomycosis infections currently show a significant increase, affecting about 10 % of the world population. Trichophyton rubrum is the main agent responsible for about 80 % of the reported infections. The clinical cure for onychomycos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab71854918f288083e91bc57343e495f
https://hal.science/hal-03128571