Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease

Autor: Ashwin V. Venkataraman, Ayla Mansur, Gaia Rizzo, Courtney Bishop, Yvonne Lewis, Ece Kocagoncu, Anne Lingford-Hughes, Mickael Huiban, Jan Passchier, James B. Rowe, Hideo Tsukada, David J. Brooks, Laurent Martarello, Robert A. Comley, Laigao Chen, Adam J. Schwarz, Richard Hargreaves, Roger N. Gunn, Eugenii A. Rabiner, Paul M. Matthews

Publikováno v: Venkataraman, A V, Mansur, A, Rizzo, G, Bishop, C, Lewis, Y, Kocagoncu, E, Lingford-Hughes, A, Huiban, M, Passchier, J, Rowe, J B, Tsukada, H, Brooks, D J, Martarello, L, Comley, R A, Chen, L, Schwarz, A J, Hargreaves, R, Gunn, R N, Rabiner, E A & Matthews, P M 2022, ' Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease ', Science Translational Medicine, vol. 14, no. 658, eabk1051 . https://doi.org/10.1126/scitranslmed.abk1051

Cell stress and impaired oxidative phosphorylation are central to mechanisms of synaptic loss and neurodegeneration in the cellular pathology of Alzheimer’s disease (AD). In this study, we quantified the in vivo expression of the endoplasmic reticu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f1dff4aaab7fcdad74b5dfc66d7a81
https://doi.org/10.1126/scitranslmed.abk1051

Imaging synaptic microstructure and synaptic loss in vivo in early Alzheimer’s Disease

Autor: Gaia Rizzo, Paul M. Matthews, Jan Passchier, Robert A. Comley, Anne Lingford-Hughes, Hideo Tsukada, Courtney A. Bishop, Ashwin V. Venkataraman, Laigao Chen, Richard Hargreaves, David J. Brooks, Ayla Mansur, Laurent Martarello, James B. Rowe, Roger N. Gunn, Eugenii A. Rabiner, Adam J. Schwarz, Yvonne Lewis, Mickael Huiban, Ece Kocagoncu

1.ABSTRACTBackgroundSynaptic loss and neurite dystrophy are early events in Alzheimer’s Disease (AD). We aimed to characterise early synaptic microstructural changes in vivo.MethodsMRI neurite orientation dispersion and density imaging (NODDI) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36a1470caa30c0c57536da263a5026c2
https://doi.org/10.1101/2021.11.23.21266746

Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge

Autor: David J. Nutt, E.A. Rabiner, Yvonne Lewis, Mickael Huiban, David Erritzoe, Azeem Saleem, Sara Moz, Alessandro Colasanti, John Beaver, Graham E. Searle, Gitte M. Knudsen, Anne Lingford-Hughes, Oliver D. Howes, Samuel Turton, Jan Passchier, Roger N. Gunn, Abhishekh Hulegar Ashok

Publikováno v: Neuropsychopharmacology. 45:804-810

Positron emission tomography (PET) enables non-invasive estimation of neurotransmitter fluctuations in the living human brain. While these methods have been applied to dopamine and some other transmitters, estimation of 5-hydroxytryptamine (5-HT; Ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ebae5264032597fe4ed0d24fe3dd0a
https://doi.org/10.1038/s41386-019-0567-5

Test-retest variability and reference region-based quantification of

Autor: Ayla, Mansur, Eugenii A, Rabiner, Hideo, Tsukada, Robert A, Comley, Yvonne, Lewis, Mickael, Huiban, Jan, Passchier, Roger N, Gunn

Publikováno v: J Cereb Blood Flow Metab

Mitochondrial complex I (MC-I) is an essential regulator of brain bioenergetics and can be quantified in the brain using PET radioligand (18)F-BCPP-EF. Here we evaluate the test–retest reproducibility of (18)F-BCPP-EF in humans, and assess the use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b531e4e6be287d9736f6693778c6402
https://pubmed.ncbi.nlm.nih.gov/32501157

Clinical translation of

Autor: Suraiya R, Dubash, Nicholas, Keat, Kasia, Kozlowski, Chris, Barnes, Louis, Allott, Diana, Brickute, Sam, Hill, Mickael, Huiban, Tara D, Barwick, Laura, Kenny, Eric O, Aboagye

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging

Background Fatty acids derived de novo or taken up from the extracellular space are an essential source of nutrient for cell growth and proliferation. Radiopharmaceuticals including 11C-acetate, and 18F-FAC (2-18F-fluoroacetate), have previously been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf1a70bf3891a3315070dabeb1efc64b
https://pubmed.ncbi.nlm.nih.gov/32123971