Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mickaël Rigourd"'
Autor:
Anne-Marie Aubertin, Mickaël Rigourd, Jean-Christophe Paillart, Valérie Goldschmidt, Chantal Ehresmann, Bernard Ehresmann, Roland Marquet
Publikováno v:
Journal of Biological Chemistry. 279:35923-35931
HIV-1 reverse transcription is initiated from a tRNA(3)(Lys) molecule annealed to the viral RNA at the primer binding site (PBS), but the structure of the initiation complex of reverse transcription remains controversial. Here, we performed in situ s
Autor:
Valérie Goldschmidt, Mickaël Rigourd, Fabienne Brulé, Casey D. Morrow, Chantal Ehresmann, Bernard Ehresmann, Roland Marquet
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2003, 31, pp.5764-75
Nucleic Acids Research, Oxford University Press, 2003, 31, pp.5764-75
Reverse transcription of HIV-1 RNA is initiated from the 3' end of a tRNA 3 Lys molecule annealed to the primer binding site (PBS). An additional interaction between the anticodon loop of tRNA 3 Lys and a viral A-rich loopis required for efficient in
Autor:
Chantal Ehresmann, Mickaël Rigourd, Philippe Benas, Stuart F. J. Le Grice, Bernard Ehresmann, Roland Marquet, Guillaume Bec
Publikováno v:
Biochimie. 85:521-525
HIV-1 utilizes cellular tRNA(3)(Lys) to prime the initiation of reverse transcription. The selective incorporation of cytoplasmic tRNA(3)(Lys) into HIV-1 particles was recently shown to involve the lysyl-tRNA synthetase, and hence, the encapsidated t
Publikováno v:
Journal of Biological Chemistry. 277:18611-18618
Azidothymidine (AZT) is a widely used inhibitor of type 1 human immunodeficiency virus reverse transcriptase (RT) that acts as chain terminator. Upon treatment, mutations conferring AZT resistance to RT are gradually selected. It has been shown that
Autor:
Valérie Goldschmidt, Stuart F.J. Le Grice, Mickaël Rigourd, Bernard Ehresmann, Roland Marquet, Chantal Ehresmann
Publikováno v:
The Journal of biological chemistry. 277(45)
Initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription requires specific recognition between the viral RNA (vRNA), tRNA(3)(Lys), which acts as primer, and reverse transcriptase (RT). The specificity of this ternary complex is
Publikováno v:
RNA
RNA, Cold Spring Harbor Laboratory Press, 2000, 6 (10), pp.1403-12. ⟨10.1017/S1355838200000947⟩
RNA, Cold Spring Harbor Laboratory Press, 2000, 6 (10), pp.1403-12. ⟨10.1017/S1355838200000947⟩
International audience; Reverse transcription of HIV-1 viral RNA uses human tRNA(Lys)3 as a primer. Some of the modified nucleotides carried by this tRNA must play a key role in the initiation of this process, because unmodified tRNA produced in vitr
Autor:
Stuart F.J. Le Grice, Bernard Ehresmann, Roland Marquet, Mickaël Rigourd, Jean-Marc Lanchy, Chantal Ehresmann
Publikováno v:
Journal of Biological Chemistry.
Initiation of human immunodeficiency virus-1 reverse transcription requires formation of a complex containing the viral RNA, primer tRNA(3)(Lys), and reverse transcriptase. Initiation, corresponding to addition of the first six nucleotides to tRNA(3)